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Mathematics
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Advances in Artificial Intelligence, Machine Learning and Optimization
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Advances in Artificial Intelligence, Machine Learning and Optimization

A special issue of Mathematics (ISSN 2227-7390). This special issue belongs to the section "E2: Control Theory and Mechanics".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 267

Special Issue Editors

Prof. Dr. Zne-Jung Lee

E-Mail Website
Guest Editor
School of Advanced Manufacturing, Fuzhou University, Quanzhou 362200, China
Interests: artificial intelligence; machine learning; big data; data mining; computational intelligence
Prof. Dr. Liang-Hung Wang

E-Mail Website
Guest Editor
Department of Microelectronics, Fuzhou University, Fuzhou 350116, China
Interests: low-power biological signal acquisition; detection ICs design; automatic identification; classification of heart disease analysis; ECG images features; brain–computer interface; EEG signal analysis; cardiac medical information; brain science heterogeneous data processing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue on “Advances in Artificial Intelligence, Machine Learning and Optimization”. This Special Issue aims to bring together the latest research and developments at the intersection of these three dynamic fields. Artificial Intelligence (AI), Machine Learning (ML), and Optimization play pivotal roles across various domains, shaping the future of technology, industry, medicine, and society. The potential for synergistic advancements in these areas is vast, and we are excited to explore the cutting-edge contributions driving progress in this space.

We welcome submissions that delve into, but are not limited to, the following topics:

  1. Advanced machine learning algorithms for optimization;
  2. Integration of AI techniques in optimization problems;
  3. Optimization methods for enhancing machine learning models;
  4. AI-driven approaches for large-scale optimization;
  5. Deep learning applications in solving complex optimization challenges;
  6. Metaheuristic and evolutionary algorithms in machine learning and AI;
  7. Optimization for neural network training and architecture design;
  8. Reinforcement learning for optimization and decision-making;
  9. Novel applications of AI and machine learning in optimization problems across various domains;
  10. Integrating multi-attribute decision-making techniques with AI, machine learning, and optimization methodologies in the context of advanced manufacturing, smart factories, industrial automation, and related domains.

We encourage researchers and practitioners to contribute their original research, reviews, and perspectives on these and related topics. Submissions should aim to uncover new insights, present state-of-the-art methodologies, and offer practical applications in Artificial Intelligence, Machine Learning, and Optimization.

We look forward to your valuable contributions to this Special Issue, and we are confident that the collective expertise of the research community will lead to an impactful and informative compilation.

Prof. Dr. Zne-Jung Lee
Prof. Dr. Liang-Hung Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Mathematics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • artificial intelligence
  • machine learning
  • optimization
  • biocomputing
  • intelligent control
  • intelligent computing
  • data mining
  • deep learning
  • intelligent technologies and applications in engineering

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Published Papers (1 paper)

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Research

19 pages, 4910 KiB  
Article
A Novel SHAP-GAN Network for Interpretable Ovarian Cancer Diagnosis
by Jingxun Cai, Zne-Jung Lee, Zhihxian Lin and Ming-Ren Yang
Mathematics 2025, 13(5), 882; https://doi.org/10.3390/math13050882 - 6 Mar 2025
Viewed by 145
Abstract
Ovarian cancer stands out as one of the most formidable adversaries in women’s health, largely due to its typically subtle and nonspecific early symptoms, which pose significant challenges to early detection and diagnosis. Although existing diagnostic methods, such as biomarker testing and imaging, [...] Read more.
Ovarian cancer stands out as one of the most formidable adversaries in women’s health, largely due to its typically subtle and nonspecific early symptoms, which pose significant challenges to early detection and diagnosis. Although existing diagnostic methods, such as biomarker testing and imaging, can help with early diagnosis to some extent, these methods still have limitations in sensitivity and accuracy, often leading to misdiagnosis or missed diagnosis. Ovarian cancer’s high heterogeneity and complexity increase diagnostic challenges, especially in disease progression prediction and patient classification. Machine learning (ML) has outperformed traditional methods in cancer detection by processing large datasets to identify patterns missed by conventional techniques. However, existing AI models still struggle with accuracy in handling imbalanced and high-dimensional data, and their “black-box” nature limits clinical interpretability. To address these issues, this study proposes SHAP-GAN, an innovative diagnostic model for ovarian cancer that integrates Shapley Additive exPlanations (SHAP) with Generative Adversarial Networks (GANs). The SHAP module quantifies each biomarker’s contribution to the diagnosis, while the GAN component optimizes medical data generation. This approach tackles three key challenges in medical diagnosis: data scarcity, model interpretability, and diagnostic accuracy. Results show that SHAP-GAN outperforms traditional methods in sensitivity, accuracy, and interpretability, particularly with high-dimensional and imbalanced ovarian cancer datasets. The top three influential features identified are PRR11, CIAO1, and SMPD3, which exhibit wide SHAP value distributions, highlighting their significant impact on model predictions. The SHAP-GAN network has demonstrated an impressive accuracy rate of 99.34% on the ovarian cancer dataset, significantly outperforming baseline algorithms, including Support Vector Machines (SVM), Logistic Regression (LR), and XGBoost. Specifically, SVM achieved an accuracy of 72.78%, LR achieved 86.09%, and XGBoost achieved 96.69%. These results highlight the superior performance of SHAP-GAN in handling high-dimensional and imbalanced datasets. Furthermore, SHAP-GAN significantly alleviates the challenges associated with intricate genetic data analysis, empowering medical professionals to tailor personalized treatment strategies for individual patients. Full article
(This article belongs to the Special Issue Advances in Artificial Intelligence, Machine Learning and Optimization)
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