Ulcerative Colitis: Pathogenesis, Clinical Management, and Emerging Therapies
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Gastroenterology & Hepatology".
Deadline for manuscript submissions: 30 May 2026 | Viewed by 36
Special Issue Editors
Interests: gastroenterology; IBDs; nutrition
Special Issue Information
Dear Colleagues,
Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine characterized by continuous inflammation of the mucous membrane. Even today, after many years of research, its exact pathogenesis remains unclear, involving a complex interaction between genetic predisposition, environmental factors, immune imbalance, and modifications in the gut microbiome. The disease is a complex interaction with a genetic background, directly related to both environmental factors and modifications in the intestinal microbiome. Advances in molecular biology and immunology have enhanced our understanding. However, translating this knowledge into successful, personalized therapies remains a significant challenge. In clinical practice, the management of UC has evolved significantly with the introduction of new biologics, small molecules, and therapeutic approaches aimed at mucosal repair, sustained remission, and improved quality of life.
This Special Issue seeks to compile original research, reviews, and viewpoints that investigate recent advancements in UC, covering aspects such as disease mechanisms, diagnostic breakthroughs, emerging treatments, and long-term patient results. The objective is to gather all recent information regarding the potential development of a specialized algorithm for diagnosing and monitoring these patients, ultimately aiming to enhance their quality of life.
Innovative biological treatments, thorough examination of the disease's pathogenesis, the impact of the microbiome on disease progression or treatment success, cutting-edge molecular monitoring techniques, and the potential applications of artificial intelligence in disease diagnosis or progression prediction continue to be the main focus of this study. Suitable submissions for this Special Issue include original research articles, clinical studies (such as randomized controlled trials, observational studies, cohort analyses), systematic reviews, and meta-analyses.
Dr. Olga Giouleme
Guest Editor
Dr. Alexandra Menni
Guest Editor Assistant
Manuscript Submission Information
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Keywords
- ulcerative colitis
- biological therapies
- microbiome
- innovative techniques
- drug monitoring
- prognostic tools
- diagnosis and treatment algorithm
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