Bone Metabolic Disease: Diagnosis, Prevention and Therapy

Dear Colleagues,

Bones are dynamic organs that undergo constant remodeling. Bone resorption and formation are controlled by local and systemic factors to ensure the structure of bones and regulate calcium and phosphorus levels in blood. Additionally, bone plays an endocrine function, secreting bone-derived hormones that exert an effect on the whole body metabolism.

Metabolic bone diseases are disorders in bone strength usually caused by imbalances in minerals (such as calcium or phosphorus), vitamin D and other endocrine disorders including diabetes or thyroid disease.  The most common metabolic bone diseases include osteoporosis, osteomalacia, flurosis primary hyperparathyroidism (PHPT), renal osteodystrophy and Paget’s disease. In clinical terms, metabolic bone diseases result in bone pain, higher risk of fractures and dysregulation of mineral levels in blood, reducing patients’ quality of life.

While our understanding of bone metabolism has increased in the last years, there are still gaps in our knowledge of the pathophysiology, diagnosis and therapy of bone metabolic disorders and their implication for the whole-body metabolism.

This Special Issue of Medical Sciences invites researchers to contribute with original research articles and reviews in all the aspects of bone metabolism. Topics of interest include but are not limited to: (1) basic studies in bone metabolism and metabolic diseases (2) the physiopathology of metabolic bone diseases (osteoporosis, osteomalacia, PHPT, renal osteodystrophy and Paget’s disease, etc) (3) preclinical treatments and diagnosis tools for bone metabolic diseases (4) other emerging areas in the bone research fields including new models for preclinical trials (e.g. microfluidics for bone diseases, bone senescence, osteoimmunology, osteomicrobiology, etc.).

Dr. Cristina Sánchez-De-Diego
Guest Editor

Manuscript Submission Information

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• bone mineral density (BMD)
• bone fragility
• osteoblast
• osteoclast
• bone quality
• osteoporosis
• chronic kidney disease (CDK)
• diabetes