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Medical Sciences, Volume 12, Issue 1

2024 March - 16 articles

Cover Story: Despite the huge impact that cardiovascular disease has on health worldwide, there remains a paucity of meaningful treatment options in patients that are not amenable to endovascular or surgical intervention. In this study, we undertake a comprehensive review of the current state of research on the extracellular matrix for the treatment of cardiovascular pathologies with a particular emphasis on ischemic heart disease. We discuss in detail the various components of the extracellular matrix and the effect of tissue source material on the effects of the extracellular matrix when used as a treatment for myocardial ischemia. Furthermore, we discuss the current limitations and potential future directions of this field of research. View this paper
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Articles (16)

  • Review
  • Open Access
4 Citations
8,273 Views
13 Pages

Pituitary Adenoma in the Philippines: A Scoping Review on the Treatment Gaps, Challenges, and Current State of Care

  • Mykha Marie B. Tabuzo,
  • Mary Angeline Luz U. Hernandez,
  • Annabell E. Chua,
  • Patricia D. Maningat and ,
  • Harold Henrison C. Chiu and
  • Roland Dominic G. Jamora
  • + 1 author+ 0 author

19 March 2024

Background: Pituitary adenomas are benign brain tumors that impose a heavy burden on patients worldwide. The local burden of disease is yet to be established due to scarcity of data. In line with this, this study aims to present the challenges and ga...

(This article belongs to the Section Endocrinology and Metabolic Diseases)
  • Article
  • Open Access
1 Citations
3,470 Views
12 Pages

10 March 2024

Breast cancer in men represents approximately 1% of all breast cancer diagnoses. Among all patients with breast cancer, approximately 30% will develop brain metastases. Over the past decade, there have been multiple advances in the treatment of metas...

(This article belongs to the Section Cancer and Cancer-Related Research)
  • Article
  • Open Access
2 Citations
2,924 Views
12 Pages

Immunogenetic Background of Chronic Lymphoproliferative Disorders in Romanian Patients—Case Control Study

  • Maria Tizu,
  • Bogdan Calenic,
  • Ion Maruntelu,
  • Andreea Mirela Caragea and ,
  • Adriana Talangescu,
  • Larisa Ursu,
  • Corina Rotarescu,
  • Mariana Surugiu,
  • Alexandra Elena Constantinescu and
  • Ileana Constantinescu
  • + 5 authors+ 0 author

23 February 2024

Background and Objectives: The implications of the genetic component in the initiation and development of chronic lymphoproliferative disorders have been the subject of intense research efforts. Some of the most important genes involved in the occurr...

  • Brief Report
  • Open Access
8 Citations
3,528 Views
7 Pages

Association of Cannabis Use Disorder with Major Adverse Cardiac and Cerebrovascular Events in Older Non-Tobacco Users: A Population-Based Analysis

  • Avilash Mondal,
  • Sriharsha Dadana,
  • Poojan Parmar,
  • Maneeth Mylavarapu and ,
  • Qiming Dong,
  • Samia Rauf Butt,
  • Abeera Kali,
  • Bhaswanth Bollu and
  • Rupak Desai
  • + 4 authors+ 0 author

19 February 2024

Background: Tobacco use disorder (TUD) adversely impacts older patients with established cardiovascular disease (CVD) risk. However, CVD risk in chronic habitual cannabis users without the confounding impact of TUD hasn’t been explored. We aime...

  • Review
  • Open Access
25 Citations
12,119 Views
25 Pages

Hereditary Renal Cancer Syndromes

  • Grigory A. Yanus,
  • Ekaterina Sh. Kuligina and
  • Evgeny N. Imyanitov

18 February 2024

Familial kidney tumors represent a rare variety of hereditary cancer syndromes, although systematic gene sequencing studies revealed that as many as 5% of renal cell carcinomas (RCCs) are associated with germline pathogenic variants (PVs). Most insta...

(This article belongs to the Section Cancer and Cancer-Related Research)
  • Review
  • Open Access
22 Citations
13,271 Views
26 Pages

Clinical Evidence on the Potential Beneficial Effects of Diet and Dietary Supplements against COVID-19 Infection Risk and Symptoms’ Severity

  • Eleni Pavlidou,
  • Efthymios Poulios,
  • Sousana K. Papadopoulou,
  • Aristeidis Fasoulas and ,
  • Antonios Dakanalis and
  • Constantinos Giaginis
  • + 1 author+ 0 author

17 February 2024

Background: Diet and dietary supplements aim to add trace elements, vitamins, and minerals to the body to improve human health and boost the immune system. In the previous few years, the new SARS-CoV-2 coronavirus strain has been threatening the heal...

  • Review
  • Open Access
15 Citations
10,477 Views
17 Pages

Portable Dynamic Chest Radiography: Literature Review and Potential Bedside Applications

  • Maurizio Cè,
  • Giancarlo Oliva,
  • Francesca Lucrezia Rabaiotti,
  • Laura Macrì and ,
  • Sharon Zollo,
  • Alessandro Aquila and
  • Michaela Cellina
  • + 2 authors+ 0 author

7 February 2024

Dynamic digital radiography (DDR) is a high-resolution radiographic imaging technique using pulsed X-ray emission to acquire a multiframe cine-loop of the target anatomical area. The first DDR technology was orthostatic chest acquisitions, but new po...

  • Review
  • Open Access
11 Citations
11,307 Views
13 Pages

Revealing Insights: A Comprehensive Overview of Gastric Outlet Obstruction Management, with Special Emphasis on EUS-Guided Gastroenterostomy

  • Dimitrios Ziogas,
  • Thomas Vasilakis,
  • Christina Kapizioni,
  • Eleni Koukoulioti and ,
  • Georgios Tziatzios,
  • Paraskevas Gkolfakis,
  • Antonio Facciorusso and
  • Ioannis S. Papanikolaou
  • + 3 authors+ 0 author

1 February 2024

Gastric outlet obstruction (GOO) poses a common and challenging clinical scenario, characterized by mechanical blockage in the pylorus, distal stomach, or duodenum, resulting in symptoms such as nausea, vomiting, abdominal pain, and early satiety. It...

  • Review
  • Open Access
12 Citations
6,777 Views
28 Pages

The Current State of Extracellular Matrix Therapy for Ischemic Heart Disease

  • Khaled Hamsho,
  • Mark Broadwin,
  • Christopher R. Stone,
  • Frank W. Sellke and
  • M. Ruhul Abid

29 January 2024

The extracellular matrix (ECM) is a three-dimensional, acellular network of diverse structural and nonstructural proteins embedded within a gel-like ground substance composed of glycosaminoglycans and proteoglycans. The ECM serves numerous roles that...

(This article belongs to the Special Issue 10th Anniversary of Medical Sciences — Advances in Basic, Translational and Clinical Research)
  • Review
  • Open Access
20 Citations
12,605 Views
12 Pages

Leukodystrophy Imaging: Insights for Diagnostic Dilemmas

  • Rajvi N. Thakkar,
  • Drashti Patel,
  • Ivelina P. Kioutchoukova,
  • Raja Al-Bahou and ,
  • Pranith Reddy,
  • Devon T. Foster and
  • Brandon Lucke-Wold
  • + 2 authors+ 0 author

25 January 2024

Leukodystrophies, a group of rare demyelinating disorders, mainly affect the CNS. Clinical presentation of different types of leukodystrophies can be nonspecific, and thus, imaging techniques like MRI can be used for a more definitive diagnosis. Thes...

(This article belongs to the Special Issue 10th Anniversary of Medical Sciences — Advances in Basic, Translational and Clinical Research)
  • Review
  • Open Access
6 Citations
4,844 Views
12 Pages

Techniques and Technologies to Improve Vein Graft Patency in Coronary Surgery

  • Marco Gemelli,
  • Mariangela Addonizio,
  • Veronica Geatti,
  • Michele Gallo and ,
  • Lauren K. Dixon,
  • Mark S. Slaughter and
  • Gino Gerosa
  • + 2 authors+ 0 author

11 January 2024

Vein grafts are the most used conduits in coronary artery bypass grafting (CABG), even though many studies have suggested their lower patency compared to arterial alternatives. We have reviewed the techniques and technologies that have been investiga...

(This article belongs to the Section Cardiovascular Disease)
  • Review
  • Open Access
14 Citations
5,416 Views
34 Pages

6 January 2024

Neuroblastoma, a paediatric malignancy with high rates of cancer-related morbidity and mortality, is of significant interest to the field of paediatric cancers. High-risk NB tumours are usually metastatic and result in survival rates of less than 50%...

(This article belongs to the Section Cancer and Cancer-Related Research)
  • Review
  • Open Access
55 Citations
6,988 Views
21 Pages

Extracellular Vesicles’ Role in Angiogenesis and Altering Angiogenic Signaling

  • Maryam Ateeq,
  • Mark Broadwin,
  • Frank W. Sellke and
  • M. Ruhul Abid

3 January 2024

Angiogenesis, the process of new blood vessels formation from existing vasculature, plays a vital role in development, wound healing, and various pathophysiological conditions. In recent years, extracellular vesicles (EVs) have emerged as crucial med...

(This article belongs to the Special Issue 10th Anniversary of Medical Sciences — Advances in Basic, Translational and Clinical Research)
  • Article
  • Open Access
4 Citations
3,830 Views
9 Pages

Machine Learning-Based Predictive Model of Aortic Valve Replacement Modality Selection in Severe Aortic Stenosis Patients

  • Ronpichai Chokesuwattanaskul,
  • Aisawan Petchlorlian,
  • Piyoros Lertsanguansinchai,
  • Paramaporn Suttirut and ,
  • Narut Prasitlumkum,
  • Suphot Srimahachota and
  • Wacin Buddhari
  • + 2 authors+ 0 author

29 December 2023

The current recommendation for bioprosthetic valve replacement in severe aortic stenosis (AS) is either surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). We evaluated the performance of a machine learning-base...

(This article belongs to the Section Cardiovascular Disease)
  • Article
  • Open Access
16 Citations
23,428 Views
15 Pages

Enhancing Sleep Quality: Assessing the Efficacy of a Fixed Combination of Linden, Hawthorn, Vitamin B1, and Melatonin

  • Matteo De Simone,
  • Rosario De Feo,
  • Anis Choucha,
  • Elena Ciaglia and
  • Francis Fezeu

28 December 2023

Sleep is essential for overall health, yet various sleep disorders disrupt normal sleep patterns, affecting duration, quality, and timing. This pilot study investigate the impact of a food supplement (SPINOFF®) on both sleep quality and mental we...

  • Review
  • Open Access
32 Citations
11,360 Views
22 Pages

23 December 2023

One of the most prevalent primary malignant brain tumors is glioblastoma (GB). About 6 incidents per 100,000 people are reported annually. Most frequently, these tumors are linked to a poor prognosis and poor quality of life. There has been little ad...

(This article belongs to the Topic Advances in Tumor Microenvironment)
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Med. Sci. - ISSN 2076-3271