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Medical Sciences, Volume 12, Issue 1

March 2024 - 16 articles

Cover Story: Despite the huge impact that cardiovascular disease has on health worldwide, there remains a paucity of meaningful treatment options in patients that are not amenable to endovascular or surgical intervention. In this study, we undertake a comprehensive review of the current state of research on the extracellular matrix for the treatment of cardiovascular pathologies with a particular emphasis on ischemic heart disease. We discuss in detail the various components of the extracellular matrix and the effect of tissue source material on the effects of the extracellular matrix when used as a treatment for myocardial ischemia. Furthermore, we discuss the current limitations and potential future directions of this field of research. View this paper
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Articles (16)

  • Review
  • Open Access
1 Citations
6,367 Views
13 Pages

Pituitary Adenoma in the Philippines: A Scoping Review on the Treatment Gaps, Challenges, and Current State of Care

  • Mykha Marie B. Tabuzo,
  • Mary Angeline Luz U. Hernandez,
  • Annabell E. Chua,
  • Patricia D. Maningat,
  • Harold Henrison C. Chiu and
  • Roland Dominic G. Jamora

19 March 2024

Background: Pituitary adenomas are benign brain tumors that impose a heavy burden on patients worldwide. The local burden of disease is yet to be established due to scarcity of data. In line with this, this study aims to present the challenges and ga...

  • Article
  • Open Access
2,847 Views
12 Pages

10 March 2024

Breast cancer in men represents approximately 1% of all breast cancer diagnoses. Among all patients with breast cancer, approximately 30% will develop brain metastases. Over the past decade, there have been multiple advances in the treatment of metas...

  • Article
  • Open Access
2 Citations
2,538 Views
12 Pages

Immunogenetic Background of Chronic Lymphoproliferative Disorders in Romanian Patients—Case Control Study

  • Maria Tizu,
  • Bogdan Calenic,
  • Ion Maruntelu,
  • Andreea Mirela Caragea,
  • Adriana Talangescu,
  • Larisa Ursu,
  • Corina Rotarescu,
  • Mariana Surugiu,
  • Alexandra Elena Constantinescu and
  • Ileana Constantinescu

23 February 2024

Background and Objectives: The implications of the genetic component in the initiation and development of chronic lymphoproliferative disorders have been the subject of intense research efforts. Some of the most important genes involved in the occurr...

  • Brief Report
  • Open Access
6 Citations
3,017 Views
7 Pages

Association of Cannabis Use Disorder with Major Adverse Cardiac and Cerebrovascular Events in Older Non-Tobacco Users: A Population-Based Analysis

  • Avilash Mondal,
  • Sriharsha Dadana,
  • Poojan Parmar,
  • Maneeth Mylavarapu,
  • Qiming Dong,
  • Samia Rauf Butt,
  • Abeera Kali,
  • Bhaswanth Bollu and
  • Rupak Desai

19 February 2024

Background: Tobacco use disorder (TUD) adversely impacts older patients with established cardiovascular disease (CVD) risk. However, CVD risk in chronic habitual cannabis users without the confounding impact of TUD hasn’t been explored. We aime...

  • Review
  • Open Access
12 Citations
8,607 Views
25 Pages

Hereditary Renal Cancer Syndromes

  • Grigory A. Yanus,
  • Ekaterina Sh. Kuligina and
  • Evgeny N. Imyanitov

18 February 2024

Familial kidney tumors represent a rare variety of hereditary cancer syndromes, although systematic gene sequencing studies revealed that as many as 5% of renal cell carcinomas (RCCs) are associated with germline pathogenic variants (PVs). Most insta...

  • Review
  • Open Access
16 Citations
9,751 Views
26 Pages

Clinical Evidence on the Potential Beneficial Effects of Diet and Dietary Supplements against COVID-19 Infection Risk and Symptoms’ Severity

  • Eleni Pavlidou,
  • Efthymios Poulios,
  • Sousana K. Papadopoulou,
  • Aristeidis Fasoulas,
  • Antonios Dakanalis and
  • Constantinos Giaginis

17 February 2024

Background: Diet and dietary supplements aim to add trace elements, vitamins, and minerals to the body to improve human health and boost the immune system. In the previous few years, the new SARS-CoV-2 coronavirus strain has been threatening the heal...

  • Review
  • Open Access
9 Citations
7,845 Views
17 Pages

Portable Dynamic Chest Radiography: Literature Review and Potential Bedside Applications

  • Maurizio Cè,
  • Giancarlo Oliva,
  • Francesca Lucrezia Rabaiotti,
  • Laura Macrì,
  • Sharon Zollo,
  • Alessandro Aquila and
  • Michaela Cellina

7 February 2024

Dynamic digital radiography (DDR) is a high-resolution radiographic imaging technique using pulsed X-ray emission to acquire a multiframe cine-loop of the target anatomical area. The first DDR technology was orthostatic chest acquisitions, but new po...

  • Review
  • Open Access
8 Citations
8,366 Views
13 Pages

Revealing Insights: A Comprehensive Overview of Gastric Outlet Obstruction Management, with Special Emphasis on EUS-Guided Gastroenterostomy

  • Dimitrios Ziogas,
  • Thomas Vasilakis,
  • Christina Kapizioni,
  • Eleni Koukoulioti,
  • Georgios Tziatzios,
  • Paraskevas Gkolfakis,
  • Antonio Facciorusso and
  • Ioannis S. Papanikolaou

1 February 2024

Gastric outlet obstruction (GOO) poses a common and challenging clinical scenario, characterized by mechanical blockage in the pylorus, distal stomach, or duodenum, resulting in symptoms such as nausea, vomiting, abdominal pain, and early satiety. It...

  • Review
  • Open Access
7 Citations
5,300 Views
28 Pages

The Current State of Extracellular Matrix Therapy for Ischemic Heart Disease

  • Khaled Hamsho,
  • Mark Broadwin,
  • Christopher R. Stone,
  • Frank W. Sellke and
  • M. Ruhul Abid

29 January 2024

The extracellular matrix (ECM) is a three-dimensional, acellular network of diverse structural and nonstructural proteins embedded within a gel-like ground substance composed of glycosaminoglycans and proteoglycans. The ECM serves numerous roles that...

  • Review
  • Open Access
7 Citations
8,471 Views
12 Pages

Leukodystrophy Imaging: Insights for Diagnostic Dilemmas

  • Rajvi N. Thakkar,
  • Drashti Patel,
  • Ivelina P. Kioutchoukova,
  • Raja Al-Bahou,
  • Pranith Reddy,
  • Devon T. Foster and
  • Brandon Lucke-Wold

25 January 2024

Leukodystrophies, a group of rare demyelinating disorders, mainly affect the CNS. Clinical presentation of different types of leukodystrophies can be nonspecific, and thus, imaging techniques like MRI can be used for a more definitive diagnosis. Thes...

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Med. Sci. - ISSN 2076-3271