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Announcements
24 April 2025
World Malaria Day—“Malaria Ends with Us: Reinvest, Reimagine, Reignite”, 25 April 2025

World Malaria Day, observed annually on 25 April, is a global reminder of the urgent need to stay focused on the fight against malaria—a preventable and treatable disease that still threatens millions of lives, especially in vulnerable communities. Despite considerable progress over the past two decades, malaria continues to take a heavy toll, particularly in sub-Saharan Africa, where children under five remain at most risk.
The theme for 2025, “Malaria Ends with Us: Reinvest, Reimagine, Reignite”, is a powerful call to action. It is a strong reminder that the fight against malaria is not over, and that the power to end it lies with all of us.
In recognition of this vital cause, MDPI is spotlighting impactful research across a selection of its journals, highlighting contributions that advance the understanding, prevention, and treatment of malaria. Featured journals include Cells, Insects, Journal of Clinical Medicine (JCM), Metabolites, Parasitologia, Pathogens, Pharmaceuticals, Reports, and TropicalMed. By bringing these articles to the forefront, MDPI reaffirms its commitment to open access knowledge and global health equity.

Prof. Tu Youyou was awarded the Nobel Prize in Physiology or Medicine in 2015 for discovering artemisinin, a drug that has significantly reduced the mortality rates for patients suffering from malaria.
To honor Prof. Tu Youyou’s remarkable contributions and to continue with her achievements, MDPI established the Tu Youyou Award in 2016. This award aims to acknowledge exceptional scholars committed to the research fields of natural products chemistry and medicinal chemistry.
The winners of the 2024 Tu Youyou Award will be announced on 30 April. Visit the award website for the latest updates!

“Blood Source and Anesthetics Effects on the Maintenance of Anopheles darlingi in the Lab-Rearing Condition”
by José Daniel Costa Pontual, Natália Vitória Coelho, Najara Akira Costa dos Santos, Alessandra da Silva Bastos, Jéssica Evangelista Araújo, Alice Oliveira Andrade, Jansen Fernandes Medeiros and Maisa da Silva Araujo
Insects 2025, 16(3), 281; https://doi.org/10.3390/insects16030281
“Identification of Bioactive Metabolites of Capirona macrophylla by Metabolomic Analysis, Molecular Docking, and In Vitro Antiparasitic Assays”
by Joseph Evaristo, Elise de Laia, Bruna Tavares, Esdras Mendonça, Larissa Grisostenes, Caroline Rodrigues, Welington do Nascimento, Carolina Garcia, Sheila Guterres, Fábio Nogueira et al.
Metabolites 2025, 15(3), 157; https://doi.org/10.3390/metabo15030157
“Duplication of a Type-P5B-ATPase in Laverania and Avian Malaria Parasites and Implications About the Evolution of Plasmodium”
by Mark F. Wiser
Parasitologia 2025, 5(1), 6; https://doi.org/10.3390/parasitologia5010006
“Effect of Health Education Intervention on Knowledge and Adherence to Intermittent Preventive Treatment of Malaria in Pregnancy Among Women”
by Pauline N. Atser, Gommaa Hayat and Uchenna B. Okafor
Healthcare 2025, 13(2), 105; https://doi.org/10.3390/healthcare13020105
“Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy”
by Alessandro Giraudo, Cristiano Bolchi, Marco Pallavicini, Roberto Di Santo, Roberta Costi and Francesco Saccoliti
Pharmaceuticals 2025, 18(1), 28; https://doi.org/10.3390/ph18010028
“Contribution of Magnetic Resonance Imaging Studies to the Understanding of Cerebral Malaria Pathogenesis”
by Alicia Comino Garcia-Munoz, Isabelle Varlet, Georges Emile Grau, Teodora-Adriana Perles-Barbacaru and Angèle Viola
Pathogens 2024, 13(12), 1042; https://doi.org/10.3390/pathogens13121042
“Prophylaxis Failure and Successful Management of Delayed-Onset Malaria with Renal Complications: A Case Report with Oral Artemether-Lumefantrine Treatment”
by Ilir Tolaj, Gramoz Bunjaku, Murat Mehmeti and Yllka Begolli
Reports 2023, 6(4), 53; https://doi.org/10.3390/reports6040053
“Sensitivity Assessment of a Multiplex and Real-Time PCR Protocols for the Detection of Malaria in External Quality Control Samples in the Malaria Reference Center in Greece”
by Nikolaos Tegos, Christos Goumenopoulos, Anastasia Mpimpa, Vasilios Papavasilopoulos, Stavroula Beleri and Eleni Patsoula
Parasitologia 2024, 4(2), 150-161; https://doi.org/10.3390/parasitologia4020013
“Prevention of Malaria in Pregnant Women and Its Effects on Maternal and Child Health, the Case of Centre Hospitalier de Kingasani II in the Democratic Republic of the Congo”
by Japhet Kabalu Tshiongo, Trésor Zola Matuvanga, Patrick Mitashi, Vivi Maketa, Henk D. F. H. Schallig, Petra F. Mens, Hypolite Muhindo Mavoko and Junior Matangila Rika
Trop. Med. Infect. Dis. 2024, 9(5), 92; https://doi.org/10.3390/tropicalmed9050092
“An Epidemiological Survey of Malaria Infection in Espírito Santo State, Brazil, from 2007 to 2017”
by Nayna Carvalho Oliveira, Lais Rosa Boscalha, Cinthia Emerich Toledo, Felipe Sarlo Pezzin, Bruno Costanza Cisari, Suellen Rodrigues Maran, Laís Rodrigues Diniz, Pedro Henrique Schultz Corcino Freitas, Adenilton Cruzeiro, Frederico Eutropio et al.
Parasitologia 2023, 3(3), 215-222; https://doi.org/10.3390/parasitologia3030022
“Low Prevalence of Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions—A Multiregional Study in Central and West Africa”
by Tina Krueger, Moses Ikegbunam, Abel Lissom, Thaisa Lucas Sandri, Jacques Dollon Mbama Ntabi, Jean Claude Djontu, Marcel Tapsou Baina, Roméo Aimé Laclong Lontchi, Moustapha Maloum, Givina Zang Ella et al.
Pathogens 2023, 12(3), 455; https://doi.org/10.3390/pathogens12030455
“Impact of the COVID-19 Pandemic on Malaria Control in Africa: A Preliminary Analysis”
by Liping Gao, Qi Shi, Zhiguo Liu, Zhenjun Li and Xiaoping Dong
Trop. Med. Infect. Dis. 2023, 8(1), 67; https://doi.org/10.3390/tropicalmed8010067

23 April 2025
Meet Us at the 21st Annual International Conference of the Metabolomics Society (Metabolomics 2025), 22–26 June 2025, Prague, Czech Republic

Conference: 21st Annual International Conference of the Metabolomics Society (Metabolomics 2025)
Date: 22–26 June 2025
Place: Prague Congress Centre, Prague, Czech Republic
MDPI will be attending the 21st Annual International Conference of the Metabolomics Society (Metabolomics 2025) as an exhibitor. This meeting will be held in Prague, Czech Republic, from 22 to 26 June 2025.
This conference is the official annual meeting of the Metabolomics Society and the largest metabolomics meeting worldwide. The major scientific themes of the conference will include metabolomics in health and disease; metabolomics of plants, food, environment, and microbes; technology advances in metabolomics; and computational metabolomics, statistics, and bioinformatics. Beyond the main topics, the conference will place a particular focus on the increasingly important role that metabolomics plays in fundamental biology research. The scientific program will include plenary and keynote talks, parallel scientific sessions, interactive poster sessions, sponsor lunches, and specially organized workshops.
The following MDPI journals will be represented at the conference:
- Metabolites;
- Cells;
- Marine Drugs;
- Proteomes;
- Current Issues in Molecular Biology;
- Nutrients;
- Biomolecules;
- International Journal of Molecular Sciences;
- Diabetology;
- Plants;
- Agronomy;
- Antioxidants;
- Applied Biosciences;
- Biomedinformatics;
- Diseases;
- Foods.
If you are planning to attend the above conference, please feel free to start a conversation with us. Our delegates look forward to meeting you in person and answering any questions that you may have. For more information about the conference, please visit the following website: https://www.metabolomics2025.org/.
17 April 2025
Metabolites Exceptional Reviewers List 2025

We are thrilled to share the updated Exceptional Reviewers List 2025. This program was designed to recognize and honor scholars who have delivered consistently exceptional review reports to our journal. Committed to fostering rigorous research and promoting knowledge exchange, Metabolites (ISSN: 2218-1989) recognizes the significant role our reviewers play in maintaining the quality and integrity of the articles we publish. According to the latest surveys conducted in 2024, 92% of our authors rate the peer review process as good or excellent, thanks to our pool of excellent reviewers.
We would like to express our sincere appreciation to all reviewers who have generously volunteered their time and expertise to assist in Metabolites’ peer review process. Their dedication and attention to detail in evaluating manuscripts, offering valuable feedback, and contributing to academic rigor are truly commendable.
The Exceptional Reviewers List was introduced in November 2024. Each quarter we will select a group of outstanding reviewers and introduce them here.
Q1:
Name: Dr. Charles Hocart
Affiliation: Australian National University, Australia
Name: Dr. David Rovnyak
Affiliation: Bucknell University, PA, USA
Name: Dr. Enrique Rodriguez
Affiliation: Universidad de Buenos Aires, Argentina
Name: Dr. Jace Jones
Affiliation: University of Maryland School of Pharmacy, MD, USA
Name: Dr. Wim Mandemakers
Affiliation: University Medical Center Rotterdam, the Netherlands
Name: Dr. Yuriy L. Orlov
Affiliation: Sechenov University, Russia
Name: Dr. Barbara J. Boucher
Affiliation: Queen Mary University of London, UK
“Reviewing papers thoroughly is a considerable task and takes time and effort but, where I know about a topic, I am glad to do that work.”
Name: Dr. Raul Díaz-Molina
Affiliation: Universidad Autónoma de Baja California, México
“In the last three and a half years I have reviewed almost 70 articles from different publishers, of which 45 articles belong to different journals of MDPI, to whom I am very grateful for their kind confidence.”
Name: Dr. Sonali Mishra
Affiliation: Washington University School of Medicine, MO, USA
"Reviewing for Metabolites has been a truly rewarding experience. The journal maintains a high standard of academic rigor while fostering a collaborative and respectful peer review environment. I’ve found the editorial team to be highly professional, responsive, and organized, which makes the process both efficient and enjoyable. Manuscripts are consistently relevant and of high scientific quality, reflecting the journal’s strong position in the field of metabolomics and related disciplines.
As a reviewer, I appreciate the journal’s clear guidelines and commitment to maintaining the integrity of the peer review process. There’s a genuine focus on improving each manuscript, and I value the opportunity to contribute constructively to the advancement of scientific knowledge. The turnaround time is well-balanced—prompt yet thorough—allowing for timely publication without compromising quality.
What stands out most is the sense of community and shared purpose among contributors. Being part of Metabolites allows me to stay engaged with cutting-edge research while playing a role in upholding the standards of scientific publishing. I highly recommend the experience to fellow researchers who are looking to support meaningful, impactful science."
Name: Dr. Zhengwei Huang
Affiliation: Jinan University, China
“It is my pleasure to review many impressive works submitted to Metabolites and other MDPI journals.”
9 April 2025
Metabolites | Selected Papers Published in 2023–2024 Related to Health and Disease

We are delighted to share some selected papers on various aspects of health and disease research that were published in our journal Metabolites (ISSN: 2218-1989) from 2023 to 2024. The following is a list of high-quality articles that we believe will be of interest to you:
1. “Enhancing Cancer Diagnosis with Real-Time Feedback: Tumor Metabolism through Hyperpolarized 1-13C Pyruvate MRSI”
by Gaurav Sharma, José S. Enriquez, Ryan Armijo, Muxin Wang, Pratip Bhattacharya and Shivanand Pudakalakatti
Metabolites 2023, 13(5), 606; https://doi.org/10.3390/metabo13050606
Available online: https://www.mdpi.com/2218-1989/13/5/606
2. “Application of Benchtop NMR for Metabolomics Study Using Feces of Mice with DSS-Induced Colitis”
by Zihao Song, Yuki Ohnishi, Seiji Osada, Li Gan, Jiaxi Jiang, Zhiyan Hu, Hiroyuki Kumeta, Yasuhiro Kumaki, Yuki Yokoi, Kiminori Nakamura et al.
Metabolites 2023, 13(5), 611; https://doi.org/10.3390/metabo13050611
Available online: https://www.mdpi.com/2218-1989/13/5/611
3. “Identification of Novel Biomarkers in Late Preterm Neonates with Respiratory Distress Syndrome (RDS) Using Urinary Metabolomic Analysis”
by Irene Christopoulou, Eirini Kostopoulou, Konstantina Matzarapi, Styliani A. Chasapi, Georgios A. Spyroulias and Anastasia Varvarigou
Metabolites 2023, 13(5), 644; https://doi.org/10.3390/metabo13050644
Available online: https://www.mdpi.com/2218-1989/13/5/644
4. “Ensemble Learning for Breast Cancer Lesion Classification: A Pilot Validation Using Correlated Spectroscopic Imaging and Diffusion-Weighted Imaging”
by Ajin Joy, Marlene Lin, Melissa Joines, Andres Saucedo, Stephanie Lee-Felker, Jennifer Baker, Aichi Chien, Uzay Emir, Paul M. Macey and M. Albert Thomas
Metabolites 2023, 13(7), 835; https://doi.org/10.3390/metabo13070835
Available online: https://www.mdpi.com/2218-1989/13/7/835
5. “Plasma Proteomics-Based Discovery of Mechanistic Biomarkers of Hyperbaric Stress and Pulmonary Oxygen Toxicity”
by Kyle J. Mahoney, Jacob S. Bowie, Austin E. Ford, Neranjan Perera, Yasuki Sekiguchi, David M. Fothergill and Elaine C. Lee
Metabolites 2023, 13(9), 970; https://doi.org/10.3390/metabo13090970
Available online: https://www.mdpi.com/2218-1989/13/9/970
6. “Low-Field Benchtop NMR to Discover Early-Onset Sepsis: A Proof of Concept”
by Matteo Stocchero, Claire Cannet, Claudia Napoli, Elena Demetrio, Eugenio Baraldi and Giuseppe Giordano
Metabolites 2023, 13(9), 1029; https://doi.org/10.3390/metabo13091029
Available online: https://www.mdpi.com/2218-1989/13/9/1029
7. “The Role of Mass Spectrometry in Hepatocellular Carcinoma Biomarker Discovery”
by Eric Yi-Liang Shen, Mei Ran Abellona U, I. Jane Cox and Simon D. Taylor-Robinson
Metabolites 2023, 13(10), 1059; https://doi.org/10.3390/metabo13101059
Available online: https://www.mdpi.com/2218-1989/13/10/1059
8. “Blood-Derived Metabolic Signatures as Biomarkers of Injury Severity in Traumatic Brain Injury: A Pilot Study”
by Elani A. Bykowski, Jamie N. Petersson, Sean P. Dukelow, Chester Ho, Chantel T. Debert, Tony Montina and Gerlinde A. S. Metz
Metabolites 2024, 14(2), 105; https://doi.org/10.3390/metabo14020105
Available online: https://www.mdpi.com/2218-1989/14/2/105
9. “Integrative Analysis of Cytokine and Lipidomics Datasets Following Mild Traumatic Brain Injury in Rats”
by Alexis N. Pulliam, Alyssa F. Pybus, David A. Gaul, Samuel G. Moore, Levi B. Wood, Facundo M. Fernández and Michelle C. LaPlaca
Metabolites 2024, 14(3), 133; https://doi.org/10.3390/metabo14030133
Available online: https://www.mdpi.com/2218-1989/14/3/133
10. “Mass Spectrometry Imaging Reveals Spatial Metabolic Alterations and Salidroside’s Effects in Diabetic Encephalopathy”
by Shuohan Cheng, Xianyue Meng, Zixuan Wang, Tianfang Lan, Zhi Zhou, Zhonghua Wang and Zeper Abliz
Metabolites 2024, 14(12), 670; https://doi.org/10.3390/metabo14120670
Available online: https://www.mdpi.com/2218-1989/14/12/670
9 April 2025
Metabolites | Hot Topic Papers Published in 2023–2024 in the “Cell Metabolism” Section

1. “Role of Oxidative Stress in Ocular Diseases: A Balancing Act”
by Daisy Y. Shu, Suman Chaudhary, Kin-Sang Cho, Anton Lennikov, William P. Miller, David C. Thorn, Menglu Yang and Tina B. McKay
Metabolites 2023, 13(2), 187; https://doi.org/10.3390/metabo13020187
Available online: https://www.mdpi.com/2218-1989/13/2/187
2. “Red Blood Cell Metabolism In Vivo and In Vitro”
by Angelo D’Alessandro, Alkmini T. Anastasiadi, Vassilis L. Tzounakas, Travis Nemkov, Julie A. Reisz, Anastsios G. Kriebardis, James C. Zimring, Steven L. Spitalnik and Michael P. Busch
Metabolites 2023, 13(7), 793; https://doi.org/10.3390/metabo13070793
Available online: https://www.mdpi.com/2218-1989/13/7/793
3. “Hyperbaric Oxygen Therapy Counters Oxidative Stress/Inflammation-Driven Symptoms in Long COVID-19 Patients: Preliminary Outcomes”
by Simona Mrakic-Sposta, Alessandra Vezzoli, Giacomo Garetto, Matteo Paganini, Enrico Camporesi, Tommaso Antonio Giacon, Cinzia Dellanoce, Jacopo Agrimi and Gerardo Bosco
Metabolites 2023, 13(10), 1032; https://doi.org/10.3390/metabo13101032
Available online: https://www.mdpi.com/2218-1989/13/10/1032
4. “Revised Harris–Benedict Equation: New Human Resting Metabolic Rate Equation”
by Eleni Pavlidou, Sousana K. Papadopoulou, Kyriakos Seroglou and Constantinos Giaginis
Metabolites 2023, 13(2), 189; https://doi.org/10.3390/metabo13020189
Available online: https://www.mdpi.com/2218-1989/13/2/189
5. “The Role of Cellular Metabolism in Maintaining the Function of the Dentine-Pulp Complex: A Narrative Review”
by Kacper Nijakowski, Martyna Ortarzewska, Jakub Jankowski, Anna Lehmann and Anna Surdacka
Metabolites 2023, 13(4), 520; https://doi.org/10.3390/metabo13040520
Available online: https://www.mdpi.com/2218-1989/13/4/520
6. “The Impact of Different Intensities of Physical Activity on Serum Urate and Gout: A Mendelian Randomization Study”
by Tangxun Yang, Shilin Bi, Xing Zhang, Mingyue Yin, Siyuan Feng and Hansen Li
Metabolites 2024, 14(1), 66; https://doi.org/10.3390/metabo14010066
Available online: https://www.mdpi.com/2218-1989/14/1/66
7. “The Urinary Metabolome of Newborns with Perinatal Complications”
by Yamilé López-Hernández, Victoria Lima-Rogel, Rupasri Mandal, Jiamin Zheng, Lun Zhang, Eponine Oler, David Alejandro García-López, Claudia Torres-Calzada, Ana Ruth Mejía-Elizondo, Jenna Poelzer et al.
Metabolites 2024, 14(1), 41; https://doi.org/10.3390/metabo14010041
Available online: https://www.mdpi.com/2218-1989/14/1/41
8. “Roles of Myokines and Muscle-Derived Extracellular Vesicles in Musculoskeletal Deterioration under Disuse Conditions”
by Jie Zhang, Yunfang Gao and Jiangwei Yan
Metabolites 2024, 14(2), 88; https://doi.org/10.3390/metabo14020088
Available online: https://www.mdpi.com/2218-1989/14/2/88
9. “Effects of Branched-Chain Amino Acids on the Inflammatory Response Induced by LPS in Caco-2 Cells”
by Bruna Ruschel Ewald Vega Garcia, Edson Naoto Makiyama, Geni Rodrigues Sampaio, Rosana Aparecida Manólio Soares-Freitas, Andrea Bonvini, Andressa Godoy Amaral, Silvana Bordin, Ricardo Ambrósio Fock and Marcelo Macedo Rogero
Metabolites 2024, 14(1), 76; https://doi.org/10.3390/metabo14010076
Available online: https://www.mdpi.com/2218-1989/14/1/76
10. “Novel Approaches to Studying SLC13A5 Disease”
by Adriana S. Beltran
Metabolites 2024, 14(2), 84; https://doi.org/10.3390/metabo14020084
Available online: https://www.mdpi.com/2218-1989/14/2/84
9 April 2025
Metabolites | Highly Cited Papers Published in 2023–2024 in the “Microbiology and Ecological Metabolomics” Section

We are delighted to share some of the highly cited papers on various aspects of gut microbiota research that were published in our journal Metabolites (2218-1989) from 2023 to 2024. The following is a list of high-quality articles and Special Issues that we believe will be of interest to you:
1. “GABA Metabolism, Transport and Their Roles and Mechanisms in the Regulation of Abiotic Stress (Hypoxia, Salt, Drought) Resistance in Plants”
by Ding Yuan, Xiaolei Wu, Binbin Gong, Ruixiao Huo, Liran Zhao, Jingrui Li, Guiyun Lü and Hongbo Gao
Metabolites 2023, 13(3), 347; https://doi.org/10.3390/metabo13030347
Available online: https://www.mdpi.com/2218-1989/13/3/347
2. “Deciphering Gut Microbiome Responses upon Microplastic Exposure via Integrating Metagenomics and Activity-Based Metabolomics”
by Pengcheng Tu, Jingchuan Xue, Huixia Niu, Qiong Tang, Zhe Mo, Xiaodong Zheng, Lizhi Wu, Zhijian Chen, Yanpeng Cai and Xiaofeng Wang
Metabolites 2023, 13(4), 530; https://doi.org/10.3390/metabo13040530
Available online: https://www.mdpi.com/2218-1989/13/4/530
3. “Interactive Effect of Dietary Gamma-Aminobutyric Acid (GABA) and Water Temperature on Growth Performance, Blood Plasma Indices, Heat Shock Proteins and GABAergic Gene Expression in Juvenile Olive Flounder Paralichthys olivaceus”
by Seunghan Lee, Mohammad Moniruzzaman, Nathaniel Farris, Taesun Min and Sungchul C. Bai
Metabolites 2023, 13(5), 619; https://doi.org/10.3390/metabo13050619
Available online: https://www.mdpi.com/2218-1989/13/5/619
4. “High-Throughput Screening of Natural Product and Synthetic Molecule Libraries for Antibacterial Drug Discovery”
by Navid J. Ayon
Metabolites 2023, 13(5), 625; https://doi.org/10.3390/metabo13050625
Available online: https://www.mdpi.com/2218-1989/13/5/625
5. “Dietary Coated Sodium Butyrate Ameliorates Hepatic Lipid Accumulation and Inflammation via Enhancing Antioxidative Function in Post-Peaking Laying Hens”
by Sasa Miao, Yan Li, Tianming Mu, Xiaoming Wang, Wenyan Zhao, Ru Li, Xinyang Dong and Xiaoting Zou
Metabolites 2023, 13(5), 650; https://doi.org/10.3390/metabo13050650
Available online: https://www.mdpi.com/2218-1989/13/5/650
6. “Certain Tomato Root Exudates Induced by Pseudomonas stutzeri NRCB010 Enhance Its Rhizosphere Colonization Capability”
by Huanhuan Zhang, Donghui Zheng, Chun Hu, Wenwen Cheng, Peng Lei, Hong Xu and Nan Gao
Metabolites 2023, 13(5), 664; https://doi.org/10.3390/metabo13050664
Available online: https://www.mdpi.com/2218-1989/13/5/664
7. “The Interplay between Gut Microbiota and Oral Medications and Its Impact on Advancing Precision Medicine”
by Sara Mousa, Muhammad Sarfraz and Walaa K. Mousa
Metabolites 2023, 13(5), 674; https://doi.org/10.3390/metabo13050674
Available online: https://www.mdpi.com/2218-1989/13/5/674
8. “Effects of Perfluorooctanoic Acid on Gut Microbiota and Microbial Metabolites in C57BL/6J Mice”
by Bei Gao, Lixia Chen, Weichen Xu, Jinjun Shan, Weishou Shen and Nan Gao
Metabolites 2023, 13(6), 707; https://doi.org/10.3390/metabo13060707
Available online: https://www.mdpi.com/2218-1989/13/6/707
9. “Role of Gamma-Aminobutyric Acid in Plant Defense Response”
by Zhujuan Guo, Junqing Gong, Shuitian Luo, Yixin Zuo and Yingbai Shen
Metabolites 2023, 13(6), 741; https://doi.org/10.3390/metabo13060741
Available online: https://www.mdpi.com/2218-1989/13/6/741
10. “AFB1 Microbial Degradation by Bacillus subtilis WJ6 and Its Degradation Mechanism Exploration Based on the Comparative Transcriptomics Approach”
by Peizhou Yang, Wenjing Wu, Danfeng Zhang, Lili Cao and Jieshun Cheng
Metabolites 2023, 13(7), 785; https://doi.org/10.3390/metabo13070785
Available online: https://www.mdpi.com/2218-1989/13/7/785
11. “Interaction and Metabolic Pathways: Elucidating the Role of Gut Microbiota in Gestational Diabetes Mellitus Pathogenesis”
by Lindong Mao, Biling Gao, Hao Chang and Heqing Shen
Metabolites 2024, 14(1), 43; https://doi.org/10.3390/metabo14010043
Available online: https://www.mdpi.com/2218-1989/14/1/43
12. “Metabolic Rewiring of Mycobacterium tuberculosis upon Drug Treatment and Antibiotics Resistance”
by Biplab Singha, Sumit Murmu, Tripti Nair, Rahul Singh Rawat, Aditya Kumar Sharma and Vijay Soni
Metabolites 2024, 14(1), 63; https://doi.org/10.3390/metabo14010063
Available online: https://www.mdpi.com/2218-1989/14/1/63
13. “The Exometabolome of Xylella fastidiosa in Contact with Paraburkholderia phytofirmans Supernatant Reveals Changes in Nicotinamide, Amino Acids, Biotin, and Plant Hormones”
by Oseias R. Feitosa-Junior, Andrea Lubbe, Suzanne M. Kosina, Joaquim Martins-Junior, Deibs Barbosa, Clelia Baccari, Paulo A. Zaini, Benjamin P. Bowen, Trent R. Northen, Steven E. Lindow et al.
Metabolites 2024, 14(2), 82; https://doi.org/10.3390/metabo14020082
Available online: https://www.mdpi.com/2218-1989/14/2/82
14. “HMOs Impact the Gut Microbiome of Children and Adults Starting from Low Predicted Daily Doses”
by Danica Bajic, Frank Wiens, Eva Wintergerst, Stef Deyaert, Aurélien Baudot and Pieter Van den Abbeele
Metabolites 2024, 14(4), 239; https://doi.org/10.3390/metabo14040239
Available online: https://www.mdpi.com/2218-1989/14/4/239
15. “Non/Low-Caloric Artificial Sweeteners and Gut Microbiome: From Perturbed Species to Mechanisms”
by Jiahao Feng, Jingya Peng, Yun-Chung Hsiao, Chih-Wei Liu, Yifei Yang, Haoduo Zhao, Taylor Teitelbaum, Xueying Wang and Kun Lu
Metabolites 2024, 14(10), 544; https://doi.org/10.3390/metabo14100544
Available online: https://www.mdpi.com/2218-1989/14/10/544
9 April 2025
Metabolites | Hot Topic Papers Published in 2023–2024 in the “Animal Metabolism” Section

1. “Effect of a Multistrain Probiotic on Feline Gut Health through the Fecal Microbiota and Its Metabolite SCFAs”
by Yifei Li, Ilyas Ali, Zhiqi Lei, Yanan Li, Min Yang, Caixia Yang and Lian Li
Metabolites 2023, 13(2), 228; https://doi.org/10.3390/metabo13020228
Available online: https://www.mdpi.com/2218-1989/13/2/228
2. “Different Types of Glucocorticoids to Evaluate Stress and Welfare in Animals and Humans: General Concepts and Examples of Combined Use”
by María Botía, Damián Escribano, Silvia Martínez-Subiela, Asta Tvarijonaviciute, Fernando Tecles, Marina López-Arjona and José J. Cerón
Metabolites 2023, 13(1), 106; https://doi.org/10.3390/metabo13010106
Available online: https://www.mdpi.com/2218-1989/13/1/106
3. “Effects of Saline-Alkaline Stress on Metabolome, Biochemical Parameters, and Histopathology in the Kidney of Crucian Carp (Carassius auratus)”
by Lu Ding, Yingjie Liu, XiaofengWei, Chuanye Geng, Wenzhi Liu, Lin Han, Fangying Yuan, Peng Wang and Yanchun Sun
Metabolites 2023, 13(2), 159; https://doi.org/10.3390/metabo13020159
Available online: https://www.mdpi.com/2218-1989/13/2/159
4. “Biological Characteristics and Energy Metabolism of Migrating Insects”
by Xiaokang Li, Yan Zhou and Kongming Wu
Metabolites 2023, 13(3), 439; https://doi.org/10.3390/metabo13030439
Available online: https://www.mdpi.com/2218-1989/13/3/439
5. “Metabolomic Changes in Rat Serum after Chronic Exposure to Glyphosate-Based Herbicide”
by Oluwatosin Daramola, Cristian D. Gutierrez Reyes, Jesús Chávez-Reyes, Bruno A. Marichal-Cancino, Judith Nwaiwu, Sherifdeen Onigbinde, Moyinoluwa Adeniyi, Joy Solomon, Md Mostofa Al Amin Bhuiyan and Yehia Mechref
Metabolites 2024, 14(1), 50; https://doi.org/10.3390/metabo14010050
Available online: https://www.mdpi.com/2218-1989/14/1/50
6. “Metabolomic Signatures of Brainstem in Mice following Acute and Subchronic Hydrogen Sulfide Exposure”
by Dong-Suk Kim, Cristina M. Santana Maldonado, Cecilia Giulivi and Wilson Kiiza Rumbeiha
Metabolites 2024, 14(1), 53; https://doi.org/10.3390/metabo14010053
Available online: https://www.mdpi.com/2218-1989/14/1/53
7. “Determination of Bile Acids in Canine Biological Samples: Diagnostic Significance”
by Krisztián Németh, Ágnes Sterczer, Dávid Sándor Kiss, Réka Katalin Lányi, Vivien Hemző, Kriszta Vámos, Tibor Bartha, Anna Buzás and Katalin Lányi
Metabolites 2024, 14(4), 178; https://doi.org/10.3390/metabo14040178
Available online: https://www.mdpi.com/2218-1989/14/4/178
8. “Daily Injection of the β2 Adrenergic Agonist Clenbuterol Improved Muscle Glucose Metabolism, Glucose-Stimulated Insulin Secretion, and Hyperlipidemia in Juvenile Lambs Following Heat-Stress-Induced Intrauterine Growth Restriction”
by Rachel L. Gibbs, James A. Wilson, Rebecca M. Swanson, Joslyn K. Beard, Zena M. Hicks, Haley N. Beer, Eileen S. Marks-Nelson, Ty B. Schmidt, Jessica L. Petersen and Dustin T. Yates
Metabolites 2024, 14(3), 156; https://doi.org/10.3390/metabo14030156
Available online: https://www.mdpi.com/2218-1989/14/3/156
9. “Identifying Predictive Biomarkers of Subclinical Mastitis in Dairy Cows through Urinary Metabotyping”
by Grzegorz Zwierzchowski, Klevis Haxhiaj , RomanWójcik, David S.Wishart and Burim N. Ametaj
Metabolites 2024, 14(4), 205; https://doi.org/10.3390/metabo14040205
Available online: https://www.mdpi.com/2218-1989/14/4/205
10. “Nuclear Magnetic Resonance (NMR) Metabolomics: Current Applications in Equine Health Assessment”
by Fulvio Laus, Marilena Bazzano, Andrea Spaterna, Luca Laghi and Andrea Marchegiani
Metabolites 2024, 14(5), 269; https://doi.org/10.3390/metabo14050269
Available online: https://www.mdpi.com/2218-1989/14/5/269
2 April 2025
MDPI INSIGHTS: The CEO's Letter #21 - Annual Report, Swiss Consortium, IWD, ICARS, Serbia

Welcome to the MDPI Insights: The CEO's Letter.
In these monthly letters, I will showcase two key aspects of our work at MDPI: our commitment to empowering researchers and our determination to facilitating open scientific exchange.
Opening Thoughts
MDPI Releases 2024 Annual Achievements Report
I’m pleased to share the release of MDPI’s 2024 Annual Achievements Report, which reflects our commitment to efficiency, transparency, and excellence in scholarly communication. The report showcases key themes related to our growth (highlighting our workforce expansion, new offices, journal milestones), excellence (editorial and publishing advancements), people (talent development and training), and community (partnerships, conferences, and outreach).
MDPI continues to build connections and drive scientific progress
Our mission remains clear: to support researchers worldwide by delivering an efficient, high-quality publishing experience while strengthening the global Open Access (OA) movement.
Advancing Open Access: A Global Knowledge Hub
In 2024, we published 238,000 peer-reviewed OA articles, reaching over 25 million downloads. This reinforces MDPI’s role as a global knowledge hub, breaking down barriers to access and ensuring that high-quality research is freely available to everyone. As part of the OA movement, we are actively democratizing knowledge, making scientific advancements accessible to researchers, policymakers, educators, and the public, without the restrictions of traditional paywalls.
Expanding our Workforce and Strengthening Research Integrity
Our global presence grew in 2024 with the opening of a new Seoul office, and our workforce expanded to 6,650 staff across 21 offices. This reflects our continued growth mindset and investment in global accessibility. We also continued to take a proactive stance on our commitment to research integrity, tripling our team in this area and joining STM’s Integrity Hub and United2Act. This means more rigorous quality control, stronger safeguards, and collaboration with global initiatives to detect and combat unethical publishing practices at an industry level. Our growth is about reinforcing our role as a trusted, ethical, and accessible publishing platform for researchers worldwide.
Growing Partnerships and Impact in Scholarly Communication
MDPI’s partnerships continue to thrive, with over 900 institutional collaborations, including a landmark agreement with ZB MED in Germany, covering more than 100 universities. Additionally, more than 90% of evaluated MDPI journals have been accepted into Web of Science, including 60 new acceptances in 2024, with nearly 300 journals expected to receive a Journal Impact Factor in 2025. In the same period, 37 MDPI journals were accepted into Scopus, bringing our total indexed titles to 306. Most importantly, 95% of authors rate their experience with MDPI as excellent or good – an achievement that underscores our dedication to serving the research community.
I encourage you to read through our Annual Report, which highlights these milestones and our vision for the future. Thank you for being part of MDPI’s journey in advancing open science.
Impactful Research
MDPI Renews Partnership with CSAL to Support Swiss Universities
I am pleased to announce the renewal of our partnership with the Consortium of Swiss Academic Libraries (CSAL) for 2025. This extension reinforces MDPI's dedication to advancing open science through transparency, efficiency, and collaboration.
Our renewed agreement with CSAL strengthens support for Swiss universities, ensuring that gold open access publishing remains both accessible and affordable for researchers across Switzerland. Among the institutions participating in this agreement are ETH Zurich and EPFL Lausanne, along with 20 other leading institutions, further expanding the reach and impact of our collaborative efforts.
To date, over 3.9 million researchers have published their findings in MDPI journals, a testament to our role in enhancing Switzerland's position as a hub for university education and research.
Inside MDPI
Celebrating International Women's Day: Accelerating Action
In honour of International Women's Day, MDPI embraced the theme “Accelerate Action,” a global call to advance women's progress by implementing effective strategies and resources. As part of our commitment, we highlighted how open access publishing empowers female voices in research and academia.
Throughout March, we featured original blogs authored by MDPI’s female contributors, showcasing the successes of our journals and employees, and addressing pressing topics such as women's health.
“Open Access supports women in education”
Women Accelerating Action Outside of MDPI
MDPI employee Ana Zdravkovic is accelerating action outside of her MDPI role as a Production Assistant. Working with like-minded women at the award-winning Belgrade-based organization UZOR OsnaŽene (meaning ‘empowered women’), they identify serious flaws in cybersecurity, and help protect women and children against online predators by providing evidence to improve legislation and laws around cyber-attacks.
In this article, we interview Ana, celebrating the important and inspiring work that she and the organisation do.
How Open Access Supports Women in Education
Every day, women and girls face barriers in education or career progression. This is caused by a range of factors, including social expectations, poverty, and poor infrastructure.
Quality opportunities and participation in the education system by women is essential to achieving equality and fulfilling their human rights.
Here, we examine how Open Access supports women in education by removing barriers and ensuring that vital research is accessible.
Recent Advancements in Research on Endometriosis
March is Endometriosis Action Month. Endometriosis is a medical condition affecting women and young girls of reproductive age, often causing symptoms such as severe pelvic pain, irregular periods, and infertility.
More research on endometriosis is still urgently needed.
This research will help develop efficient diagnoses and better treatment for those struggling with the condition.
In this article, we explore what endometriosis is and discuss the latest research advancements on the disease.
We also curated a selection of MDPI journals, articles, and Special Issues focusing on gender equity, women in the workplace, and women’s health. Find out more about these by visiting our IWD – Accelerate Action landing page.
As I reflect on the month of March and International Women’s Day, I would like to take a moment to recognize and thank all of the incredible women at MDPI for your dedication to democratizing knowledge and shaping open access. Your contributions are invaluable, and they continue to shape the future of MDPI.
Coming Together for Science
The International Conference on Advanced Remote Sensing (ICARS 2025)
The International Conference on Advanced Remote Sensing (ICARS 2025) took place from 26–28 March 2025, in Barcelona, Spain. It was chaired by Prof. Dr. Fabio Tosti from the Faringdon Research Centre for Non-Destructive Testing and Remote Sensing (UK), Prof. Dr. Andrea Benedetto from University Roma Tre (Italy), and Prof. Dr. Luis Ángel Ruiz from Universitat Politècnica de València (UPV, Spain).
Over three days, the conference explored innovations in Earth and environmental sciences, engineering advancements, and practical applications in biological and agricultural fields.
I am pleased to share that the 1st edition of ICARS 2025 was a great success, with 133 attendees out of 146 registrations. The event featured 43 short talks, 64 posters, and 103 accepted abstracts, along with nine keynote speakers and a major panel with five expert panellists.
Over 60 attendees joined the conference dinner, and the event received outstanding feedback.
The main goal of ICARS2025 was to cover how advanced remote sensing technologies are transforming our approach to global challenges.
Awards
Four awards were presented at the conclusion of the conference, sponsored by the journal Remote Sensing: Best Poster Award (€400), Best Oral Presentation Award (€400), and two Early Career Researcher Awards (1st prize: €600 and 2nd prize: €200).
Thank you to our Partnering Societies
We are grateful for the support of our four partnering societies and nine media partners, who played an important role in promoting the conference. Special thanks to our partnering societies: the European Federation of Geologists (EFG), Geoscience Energy Society of Great Britain (GESGB), Asociación Española de Teledetección (AET) – the Spanish Association of Remote Sensing, and the International Society for Digital Earth (ISDE).
Upcoming In-Person Event
31 March–2 April 2025
Plants 2025: From Seeds to Food Security
Location: Barcelona, Spain
This event will gather plant scientists to discuss the latest research on how to feed a growing population while maintaining a sustainable agro-ecosystem.
Find more upcoming MDPI events here.
Closing Thoughts
MDPI Serbia Salon 2025: A Gathering of Academic Excellence
On Tuesday, 18 March, we successfully concluded our first MDPI Serbia Salon in Belgrade. This event provided a great opportunity to showcase MDPI’s achievements, strengthen connections with the Serbian academic community, and highlight our role as the largest publisher in Serbia. We were honoured to welcome Prof. Dr. Sergej M. Ostojić, Editor-in-Chief of MDPI journal Clinical Bioenergetics, as a guest speaker.
Over the past five years, MDPI has experienced continuous growth in Serbia, with an increasing number of publications, an expansion of Editorial Board memberships, and a greater number of active peer reviewers. The Salon allowed us to express our thanks to the Serbian research community while gathering feedback from attendees representing several major universities.
Discussion topics
As part of the event, I delivered an opening speech highlighting MDPI’s achievements and direction.
The event featured presentations from MDPI colleagues, including discussions on open science, publishing ethics, and our achievements in Serbia.
A special thank-you to all our MDPI presenters, panellists, and organizers who made his event a success. I hope the MDPI Serbia Salon becomes a tradition for years to come, creating connections within the Serbian research community.
Visit to the Science Fund of Serbia and The Ministry of Science
During my visit to Belgrade, I had the opportunity to join my colleagues Emir Ramadani (Operations Manager) and Nevena Blagojev (Journal Relations Manager) in meetings with the Science Fund of Serbia and the Ministry of Science, where we received strong support for our work in Serbia.
Both organizations highly value our presence in and commitment to Serbia, where we employ over 640 staff across our two offices in Belgrade and Novi Sad. We take great pride in creating job opportunities and supporting the community in Serbia.
“There’s a lot of exciting activity happening in MDPI Serbia”
Speaking with our Serbian Colleagues
Finally, I had the opportunity to speak with our Serbian colleagues about our initiatives to expand and to improve our marketing & communication and public relations activities.
It was great to have an open discussion with colleagues – both in person and with the hundreds who joined online.
This visit to Belgrade had been a long time coming for me. Serbia is our largest operation in Europe and there’s a lot of exciting activity happening in MDPI Serbia, including the launch of a new office floor in Novi Sad and the growth and expansion of our teams.
I look forward to returning soon and continuing to support our colleagues across our Serbian offices.
Chief Executive Officer
MDPI AG
24 March 2025
World Tuberculosis Day 2025—“Yes! We Can End TB: Commit, Invest, Deliver”, 24 March 2025

Tuberculosis is a disease that is both preventable and treatable, significantly affecting people’s health and quality of life worldwide. Every year, we commemorate World Tuberculosis Day to raise public awareness of the devastating health, social, and economic consequences of tuberculosis (TB) and to intensify efforts to end the global TB epidemic. The date signifies the day in 1882 when Dr. Robert Koch announced his discovery of the bacterium responsible for TB, which paved the way for diagnosing and curing this disease. We hope that established journals in the fields of Biology Life Sciences and Medicine & Pharmacology at MDPI, including Pathogens, Microorganisms, Reports, Medical Sciences, Healthcare and Diagnostics will continue to serve as a communication platform for innovative ideas regarding prevention and treatment.
Medicine & Pharmacology | Biology Life Sciences | |
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“Impact of Severity of COVID-19 in TB Disease Patients: Experience from an Italian Infectious Disease Referral Hospital”
by Virginia Di Bari, Carlotta Cerva, Raffaella Libertone, Serena Maria Carli, Maria Musso, Delia Goletti, Alessandra Aiello, Antonio Mazzarelli, Angela Cannas, Giulia Matusali, Fabrizio Palmieri, Gina Gualano and on behalf of the TB-INMI Working Group
Infect. Dis. Rep. 2025, 17(1), 11; https://doi.org/10.3390/idr17010011
“Cigarette Smoking as a Risk Factor for Tuberculosis in Adults: Epidemiology and Aspects of Disease Pathogenesis”
by Charles Feldman, Annette J. Theron, Moloko C. Cholo and Ronald Anderson
Pathogens 2024, 13(2), 151; https://doi.org/10.3390/pathogens13020151
“Situation Analysis of Early Implementation of Programmatic Management of Tuberculosis Preventive Treatment among Household Contacts of Pulmonary TB Patients in Delhi, India”
by Yasir Alvi, Sairu Philip, Tanu Anand, Palanivel Chinnakali, Farzana Islam, Neeta Singla, Pruthu Thekkur, Ashwani Khanna and BK Vashishat
Trop. Med. Infect. Dis. 2024, 9(1), 24; https://doi.org/10.3390/tropicalmed9010024
“HLA-DPB1*05:01 and HLA-A*11:01 Is Associated with Adverse Drug Reactions to Isoniazid and Rifampin for Treatment of Latent Tuberculosis Infection in South Korea”
by Bomi Kim, Jungok Kim, Sun-Young Yoon, Hae Suk Cheong, Min-Jung Kwon, Joon-Sup Yeom, Han-Na Kim and Eun-Jeong Joo
Clin. Med. 2024, 13(12), 3563; https://doi.org/10.3390/jcm13123563
“Pharmacists’ Role in Global TB Elimination: Practices, Pitfalls, and Potential”
by Alina Cernasev, Jonathan Stillo, Jolie Black, Mythili Batchu, Elaina Bell and Cynthia A. Tschampl
Healthcare 2024, 12(11), 1137; https://doi.org/10.3390/healthcare12111137
“Metabolic Rewiring of Mycobacterium tuberculosis upon Drug Treatment and Antibiotics Resistance”
by Biplab Singha, Sumit Murmu, Tripti Nair, Rahul Singh Rawat, Aditya Kumar Sharma and Vijay Soni
Metabolites 2024, 14(1), 63; https://doi.org/10.3390/metabo14010063
“Exploring the Impact of Silicosis Incidence on Tuberculosis Mortality and Morbidity: A Multi-Country Study”
by Muayad Albadrani
Med. Sci. 2023, 11(4), 63; https://doi.org/10.3390/medsci11040063
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“Prevention, Treatment and Diagnosis of Tuberculosis, 2nd Edition” |
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“Tuberculosis in Special Populations: Epidemiology and Evidence-Based Interventions” |
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“The Old and New Faces of Epidemiology: From the Epidemiology of Infectious Diseases to Social Epidemiology” |
12 March 2025
Recruiting Early Career Editorial Board Members for Metabolites
In order to further enhance Metabolites (ISSN: 2218-1989), promote the academic exchange of young scientists, and support the Editorial Board with additional talent, the first Early Career Editorial Board of Metabolites (2025–2026) is being set up, and outstanding young scholars are invited to join!
Recruitment:
A total of 100 Early Career Editorial Board Members are planned to be recruited.
The requirements to be an Early Career Editorial Board Member (ECEBM):
- Completed their doctorate/Ph.D. degree in the past 10 years (considering exceptions for career interruptions, including medical and family leave);
- Served as the first, last, or corresponding author of at least five manuscripts published in peer-reviewed journals;
- Evidence of significant research achievements in the fields of metabolomics or metabolism;
- Researchers that are currently (at the time of application) an assistant professor, research assistant professor, associate research scientist, post-doctoral fellow, or equivalent early-career position;
- Researchers that are active and engaged in their community (e.g., experienced at presenting at academic conferences or involved in professional organizations).
Benefits of Early Career Editorial Board Members:
- A certificate of appointment as an Early Career Editorial Board Member will be provided;
- The achievements of Early Career Editorial Board Members will be publicized on the journals’ various media platforms to improve academic visibility;
- Opportunities to be promoted to a full Editorial Board Member will be provided contingent upon contributions;
- The journal will regularly acknowledge those who have participated in the peer-review process on the website;
- Opportunities to participate in or host annual meetings and online seminars organized by the Editor-in-Chief and the Editorial Board Members.
Responsibilities of an Early Career Editorial Board Member:
- Publicizing and promoting the journal at academic conferences and among peers;
- Selecting high-quality articles and preparing media content for their promotion;
- Reviewing at least four manuscripts per year;
- Identifying potential reviewers for specific papers, and assessing any potential ethical or policy-based questions that might arise due to the papers’ content;
- Supporting the development of the journal through various means, such as providing suggestions, promoting the journal via academic networks, academic conferences, and new media channels, etc.;
- Inviting submissions from world-leading scientists in their respective research fields through both local and global networks;
- Learning about the scholarly publishing landscape, including gaining an awareness of the manuscript review process, ethical considerations, and the strategies used by publishers.
Application:
Please send the application form and your academic resume to metabolites@mdpi.com with the subject “Metabolites Early Career Editorial Board Application + Name + Institute + Research Expertise”.
Application deadline: 31 July 2025.
Selection process:
Initial screening of application materials → selection by the Editor-in-Chief and Editorial Board Members → email notification → issuing a certificate of appointment.