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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bioactive Plant Extracts: Phytochemical Characterization, Isolation and Biological Evaluation

edited by

Sergio Ortiz

submission deadline 25 Aug 2025 | Viewed by 259 | Submission Open

Keywords: extraction; metabolomics; phytochemical dereplication; isolation of plant metabolites; biological evaluation

(This special issue belongs to the Section Plant Metabolism)

Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment

edited by

Susumu Muroya

submission deadline 30 Aug 2025 | 6 articles | Viewed by 14371 | Submission Open

Keywords: skeletal muscle; metabolomics; mitochondria; energy metabolism; lipid metabolism; nutrition; feeding; environment; exercise; stress

(This special issue belongs to the Section Animal Metabolism)

Mechanism of Metabolic Diseases

edited by

Dipsikha Biswas

and Logan Slade

submission deadline 30 Aug 2025 | Viewed by 846 | Submission Open

Keywords: metabolic diseases; nutrient signaling; metabolite profiling; genetic regulation; metabolomics; proteomics; organ crosstalk

(This special issue belongs to the Section Cell Metabolism)

Targeting Microbiota and Metabolites for Prevention and Treatment of Human Diseases

edited by

Zhipeng Tao

and

Danhui Wang

submission deadline 31 Aug 2025 | 9 articles | Viewed by 15634 | Submission Open

Keywords: microbiota; metabolites; metabolic diseases; cancer; cardiovascular diseases; liver diseases

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Diabetes and Metabolic Diseases: From Prevention to Clinical Management

edited by

Davide Masi

and

Renata Risi

submission deadline 31 Aug 2025 | 6 articles | Viewed by 14912 | Submission Open

Keywords: obesity; nutritional ketosis; dietary manipulations; therapeutic inertia; type 2 diabetes; gut microbiome; incretins; hormone regulation

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Drug Metabolism and New Drug Development for Cancers

edited by

Anna Jelińska

and

Szymon Tomczak

submission deadline 31 Aug 2025 | 4 articles | Viewed by 9195 | Submission Open

Keywords: cancer; new drug development; metabolites; secondary plant metabolites; drug delivery; nanoformulation; anticancer treatment

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Nutrition, Metabolism and Physiology in Aquatic Animals

edited by

Renlei Ji

and Xueshan Li

submission deadline 31 Aug 2025 | 4 articles | Viewed by 6766 | Submission Open

Keywords: nutrition; metabolism; physiology; metabolism; aquaculture; metabolome; nutrients; hazardous materials

(This special issue belongs to the Section Nutrition and Metabolism)

Secondary Metabolites and Their Activities: From the Identification to the Biological Investigation

edited by Valeria Cavalloro and

Emanuela Martino

submission deadline 31 Aug 2025 | 5 articles | Viewed by 6590 | Submission Open

Keywords: active metabolites; green extraction; bioactivity; natural products; structural elucidation

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Recent Developments and Emerging Trends in Metabolic Modelling and Metabolomics

edited by Johnjoe McFadden and

Khushboo Borah Slater

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4340 | Submission Open

Keywords: constraint-based modelling; genome scale models; metabolic flux analysis; metabolomics; infectious disease

(This special issue belongs to the Section Advances in Metabolomics)

Advances in Food Metabolomics for Functional Food Development and Analysis

edited by

Amanda J. Lloyd

and

MJ Pilar Martinez-Martin

submission deadline 31 Aug 2025 | 3 articles | Viewed by 2488 | Submission Open

Keywords: natural food fortification; functional foods; bioactive compounds; nutraceuticals; food biofortification; food analysis; nutritional enhancement; food testing; metabolomics

(This special issue belongs to the Section Food Metabolomics)

The Molecular Cargo of Extracellular Vesicles: A Key to Understanding Their Biological Role

edited by

Elisabetta Chiaradia

and

Sandra Buratta

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1773 | Submission Open

Keywords: extracellular vesicles (EVs); intercellular communication; molecular cargo; proteins in EVs; lipids in EVs; metabolites in EVs; nucleic acids in EVs; horizontal gene transfer; bioactive molecules in EVs

(This special issue belongs to the Section Cell Metabolism)

Metabolic Modulators in Cardiovascular Disease Management

edited by

Syed Siraj A. Quadri

submission deadline 31 Aug 2025 | 1 articles | Viewed by 665 | Submission Open

Keywords: metabolic modulators; cardiovascular therapeutics; mitochondrial function; cardiometabolic disorders; energy metabolism; metabolic syndrome; therapeutic targets; heart failure; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

New Trends in Drug Pharmacokinetics and Metabolism Research

edited by

Rongjin Sun

and Steven C. Laizure

submission deadline 31 Aug 2025 | Viewed by 510 | Submission Open

Keywords: local bioavailable drug; drug– herb interactions; machine learning; advanced modeling techniques; gut microbiome; in vitro to in vivo extrapolation; monoclonal antibodies; peptides; oligonucleotides

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolomic Insights: Interplay Between Metabolism and Immune Response in Cancer

edited by

Dimitra Rafailia Bakaloudi

submission deadline 31 Aug 2025 | Viewed by 502 | Submission Open

Keywords: metabolites; metabolism; cancer; immune response; immunotherapy; immunometabolism

(This special issue belongs to the Section Cell Metabolism)

Metabolomics in Food Science and Nutrition Using GC-MS

edited by

Ryota Mabuchi

Genya Okada

and

Yonghuan Yun

submission deadline 31 Aug 2025 | Viewed by 289 | Submission Open

Keywords: GC-MS; metabolome analysis; metabolic profiling; foodomics; nutritional metabolomics; dietary bi-omarkers; food quality; primary metabolites; lipidomics; odor and/or aroma components

(This special issue belongs to the Section Food Metabolomics)

Insulin Clearance and Metabolic Dysregulation in Health and Disease

edited by

Morvarid Kabir

and Richard N. Bergman

submission deadline 31 Aug 2025 | Viewed by 285 | Submission Open

Keywords: insulin clearance; insulin resistance; type 2 diabetes; obesity; hyperinsulinemia; metabolic dysfunction

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Hyperlipidemia Related Endocrine Disease and Cancer in Human and Animal

edited by

Kyuhyung Choi

submission deadline 31 Aug 2025 | Viewed by 205 | Submission Open

Keywords: hyperlipidemia; diabetes mellitus; Cushing’ s disease; pancreatitis; hepatocellular carcinoma; mammary gland tumor; colorectal cancer

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Amino Acid Metabolism in Angiogenesis

edited by Roxana Elena Oberkersch and

Teodoro Bottiglieri

submission deadline 31 Aug 2025 | Viewed by 152 | Submission Open

Keywords: amino acid metabolism; endothelial cells; angiogenesis; metabolic pathways; cellular crosstalk

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Nutrition Intake on Pet Metabolism

edited by

Giulia Pignataro

submission deadline 1 Sep 2025 | 1 articles | Viewed by 798 | Submission Open

Keywords: pet nutrition; pet food; nutraceuticals; clinical dietetics; metabolomics

(This special issue belongs to the Section Animal Metabolism)

Effects of Micronutrients on Human Metabolism

edited by

Lin Xiao

submission deadline 15 Sep 2025 | 1 articles | Viewed by 813 | Submission Open

Keywords: micronutrients; trace minerals; vitamins; human metabolism; metabolic processes; obesity; diabetes; cardiovascular disease

(This special issue belongs to the Section Food Metabolomics)

Metabolic Profiling in Neurometabolisms

edited by Larissa Daniele Bobermin

submission deadline 15 Sep 2025 | Viewed by 155 | Submission Open

Keywords: brain; energy homeostasis; glial cells; metabolic disorders; metabolic profiles; neurometabolism; neurons

Metabolomics in Chronic Disease

edited by Xiaoyu Che

submission deadline 20 Sep 2025 | Viewed by 457 | Submission Open

Keywords: metabolomics; chronic diseases; multi-omics; bioinformatics; biomarker discovery; system biology

(This special issue belongs to the Section Metabolomic Profiling Technology)

Roles of Plant Secondary Metabolites in Preventing and Treating Chemotherapy-Induced Side Effects

edited by

Woojin Kim

submission deadline 20 Sep 2025 | Viewed by 388 | Submission Open

Keywords: chemotherapy-induced side effects; pain; nausea and vomiting; neutropenia

(This special issue belongs to the Section Plant Metabolism)

Modulating Gut Microbiota and Host Interactions: The Role of Diet, Probiotics, and Circadian Rhythms

edited by Miri Park and Jeehwan Choe

submission deadline 20 Sep 2025 | Viewed by 286 | Submission Open

Keywords: gut microbiota; diet and microbiome; probiotics; prebiotics; circadian rhythms; microbial metabolites; host– microbe interactions; nutritional strategies; gut– brain axis; metabolic health

(This special issue belongs to the Section Cell Metabolism)

Multi-Omics Dissection of EMT-Driven Cancer Metabolism in Drug Resistance and Metastasis

edited by Lei Huang

submission deadline 20 Sep 2025 | Viewed by 142 | Submission Open

Keywords: multi-omics; EMT; drug-resistant; metastasis; metabolism-driven therapies

(This special issue belongs to the Section Cell Metabolism)

Exploring Pathological Mechanisms in Obesity, Diabetes, and Metabolic Syndrome

edited by

Tiemin Liu

Hongmei Yan

and

Qiongyue Zhang

submission deadline 30 Sep 2025 | 9 articles | Viewed by 18249 | Submission Open

Keywords: metabolic diseases: obesity; diabetes; NAFLD; MAFLD; NASH; metabolic syndrome; etc.; multi-omics: metabolomics; lipidomics; proteomics; etc.; pathogenesis: genetic predispositions; lifestyle factors; microbiome and environmental exposures; etc.

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in Food Sciences: Metabolomics to Unravel the Complexity of Food Metabolites

edited by

José Iván Serrano-Contreras

submission deadline 30 Sep 2025 | 2 articles | Viewed by 11064 | Submission Open

Keywords: foodomics; nutrimetabolomics; phytochemicals; food chemistry; food analysis; dark matter in diet; nutritional dark matter; nutritional hormesis; untargeted/targeted analysis

(This special issue belongs to the Section Food Metabolomics)

Unlocking Nature's Toolbox: Advances in Plant Metabolites Identification

edited by

Ramona Paltinean

and

Irina Ielciu

submission deadline 30 Sep 2025 | 7 articles | Viewed by 8019 | Submission Open

Keywords: natural compounds; plant metabolites; extraction methods; separation techniques; biological activities

(This special issue belongs to the Section Plant Metabolism)

Analysis of Specialized Metabolites in Natural Products

edited by

Aikaterini Koutsaviti

and

Christos Petrou

submission deadline 30 Sep 2025 | 6 articles | Viewed by 7237 | Submission Open

Keywords: structure elucidation; isolation; evaluation of activity; plant bioactive secondary metabolites; methodology development

(This special issue belongs to the Section Plant Metabolism)

Advances in Metabolomics and Multi-Omics Integration

edited by

Kurt K. Zhang

submission deadline 30 Sep 2025 | 4 articles | Viewed by 7141 | Submission Open

Keywords: metabolomics; cellular metabolism; multi-omics; metabolites; molecular interaction; cell– cell cross-talk

(This special issue belongs to the Section Integrative Metabolomics)

Insights into Metabolism, Diagnostics and Therapeutics of Cancer and Tumor Microenvironment by NMR Spectroscopy

edited by

Shivanand M. Pudakalakatti

and

Pratip K. Bhattacharya

submission deadline 30 Sep 2025 | 2 articles | Viewed by 5214 | Submission Open

Keywords: cancer metabolism; early diagnosis; therapeutic intervention; NMR spectroscopy; instrument development; pulse sequence design; metabolites; software for metabolomics

(This special issue belongs to the Section Integrative Metabolomics)

Metabolite Profiling of Novel Psychoactive Substances

edited by

Jeremy Carlier

and Volker Auwärter

submission deadline 30 Sep 2025 | 3 articles | Viewed by 4569 | Submission Open

Keywords: new psychoactive substances; metabolism; case report; clinical toxicology; forensic toxicology

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Nuclear Magnetic Resonance-Powered Metabolomics: Progress and Future Prospects

edited by Abhinav Dubey

submission deadline 30 Sep 2025 | 4 articles | Viewed by 4302 | Submission Open

Keywords: solution-state NMR; metabolism; clinical studies; biomarker discovery; high-throughput data analysis

(This special issue belongs to the Section Advances in Metabolomics)

Phytochemicals and Pharmacological Significance of Plant Secondary Metabolites in Medicine

edited by

Katarzyna Jakimiuk

and Arkadiusz Surażyński

submission deadline 30 Sep 2025 | 3 articles | Viewed by 3294 | Submission Open

Keywords: natural plant products; biological and pharmacological activity; isolation; disease prevention and treatment; natural plant drug discovery

(This special issue belongs to the Section Plant Metabolism)

Adrenal Neuroendocrine System and Cardiometabolic Health

edited by

Moe Thuzar

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2961 | Submission Open

Keywords: adrenal; metabolic syndrome; cardiovascular health; glucocorticoid; mineralocorticoid

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Interactions of Diet, Exercise, and Metabolism

edited by

Raphael Gonçalves de Oliveira

, Dartagnan Pinto Guedes and Laís Campos de Oliveira

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2807 | Submission Open

Keywords: physical exercise; physical fitness; physical activity; diet; food; and nutrition; feeding behavior; me-tabolism; metabolic process

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mass Spectrometry-Based Technology for Metabolic Profiling

edited by Gregory Hamm,

Laura Cole

and Lin Wang

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1846 | Submission Open

Keywords: metabolomics; lipidomic; high-resolution mass spectrometry; untargeted and targeted; data processing; pathway mapping; fluxomic

(This special issue belongs to the Section Metabolomic Profiling Technology)

Amino Acid Metabolism and Function in Human Diseases

edited by Jolanta Bugajska and Krystyna Sztefko

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1578 | Submission Open

Keywords: free amino acids; civilization diseases; obesity; diabetes; liver disease; heart diseases; reference intervals

(This special issue belongs to the Section Cell Metabolism)

Application of NMR in Food Metabolomics

edited by Charalambos Fotakis and

Maria Zervou

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1565 | Submission Open

Keywords: food items; NMR; food metabolomics; quality assurance; geographical origin; authenticity

(This special issue belongs to the Section Metabolomic Profiling Technology)

Role of Metabolic Factors and Their Interactions on Diabetes and Its Complications

edited by Yun Shen

submission deadline 30 Sep 2025 | Viewed by 590 | Submission Open

Keywords: metabolic risk factors; diabetes comorbidities; bioinformatics; machine learning; multi-omics integration; cardiovascular disease; dyslipidemia; insulin resistance; biomarkers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Lipidomic Signatures in Pediatric Metabolic Disorders

edited by

Mónica Narváez-Rivas

submission deadline 30 Sep 2025 | Viewed by 524 | Submission Open

Keywords: lipidomics; lipids; mass spectrometry; pediatric population; therapeutic targets; biomarkers; metabolic disorder

(This special issue belongs to the Section Lipid Metabolism)

Metabolomics in Clinical Research: Advancing Precision Medicine Through the Analysis of Biological Samples

edited by

Joana Pinto

submission deadline 30 Sep 2025 | Viewed by 359 | Submission Open

Keywords: metabolomics; precision medicine; biomarker discovery; clinical research; disease mechanisms; metabolic profiling; multi-omics integration; biological samples; diagnostic biomarkers; therapeutic monitoring

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Changes in Diet-Mediated Inflammatory Diseases

edited by

Beatrice Dufrusine

submission deadline 30 Sep 2025 | Viewed by 256 | Submission Open

Keywords: nutrition; Westernized diet; inflammation; immune system; cancer; metabolic reprogramming; au-toimmune disease; obesity; allergies; inflammatory bowel diseases; celiac disease

(This special issue belongs to the Section Nutrition and Metabolism)

Circadian System Associated with Lipid Metabolism and Metabolic Diseases

edited by

Xiaoyue Pan

submission deadline 30 Sep 2025 | Viewed by 210 | Submission Open

Keywords: circadian rhythm; circadian clock; lipid transport; lipid oxidation; lipid synthesis; lipid metabolism; lipoprotein

(This special issue belongs to the Section Cell Metabolism)

Biomarkers and Human Blood Metabolites 2025

edited by

Mina Hur

submission deadline 30 Sep 2025 | Viewed by 209 | Submission Open

Keywords: blood metabolites as human biomarkers; identification of disease and non-disease biomarkers; understanding the pathogenesis of the diseases through metabolites; physiological response against environmental stress or stimuli; exposure to toxin or chemical drugs; lifestyle; nutrition; and genetic or epigenetic factors

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics and Bioinformatics Approaches to Studying Human Gut Microbiota-Derived Metabolites

edited by Zhiwei Zhou, Shipei Xing and Xiaotao Shen

submission deadline 10 Oct 2025 | 2 articles | Viewed by 3492 | Submission Open

Keywords: metabolomics; bioinformatics; databases; gut microbiota; microbiome; host– microbe interaction; microbial metabolism; multiomics

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Reactive Oxygen Species and Energy Metabolic Alterations in Health and Disease

edited by

Paola Maycotte

and

Álvaro Marín-Hernández

submission deadline 15 Oct 2025 | 2 articles | Viewed by 3970 | Submission Open

Keywords: cancer; ROS; glycolysis; mitochondria; autophagy; antioxidant system; glutathione; oxidative phosphorylation

(This special issue belongs to the Section Cell Metabolism)

Effects of Secondary Plant Metabolites on Human Health

edited by

Beáta Čižmárová

and

Anna Birková

submission deadline 15 Oct 2025 | 1 articles | Viewed by 578 | Submission Open

Keywords: human health; inflammation; cancer; obesity; antioxidants; phytochemicals; phytoestrogens; secondary metabolites; natural products

(This special issue belongs to the Section Plant Metabolism)

Mass Spectrometry Imaging and Spatial Metabolomics

edited by

Zhonghua Wang

and Chenglong Sun

submission deadline 30 Oct 2025 | 4 articles | Viewed by 4446 | Submission Open

Keywords: mass spectrometry imaging (MSI); spatial metabolomics; biomarker discovery; disease diagnostics; drug development; technical advancements; interdisciplinary approaches; imaging techniques

(This special issue belongs to the Section Metabolomic Profiling Technology)

Nutritional and Metabolic Influences on Animal Growth and Reproduction

edited by