Role of Ceramides in Determining an Increased Cardiovascular and Renal Risk
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 64
Special Issue Editor
Interests: NAFLD; diabetes; ceramics; gender disparity in science
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ceramides are a class of sphingolipids involved in cellular processes such as apoptosis, inflammation, and insulin resistance. Elevated circulating levels of specific ceramides have been consistently associated with an increased risk of cardiovascular diseases (CVDs), including coronary artery disease and strokes. Studies have shown that certain ceramide species, particularly those with longer acyl chains, correlate strongly with adverse cardiovascular outcomes. These findings suggest that plasma ceramides may serve as predictive markers for identifying individuals at higher risk of CVD, potentially improving early intervention strategies.
Moreover, recent research has expanded the role of plasma ceramides to the prediction of chronic kidney disease (CKD). Elevated ceramide levels have been associated with a higher risk of CKD, suggesting that these lipids could also be used as biomarkers for renal health. This dual predictive role highlights the importance of plasma ceramides in the context of both cardiovascular and renal diseases.
Despite promising associations, the underlying mechanisms by which ceramides contribute to these diseases remain still poorly understood. This knowledge gap underscores the need for further mechanistic studies to elucidate the specific pathways through which ceramides influence cardiovascular and renal pathophysiology. Understanding these mechanisms is crucial for developing targeted therapies that could mitigate the harmful effects of ceramide accumulation and reduce the incidence of related diseases. Therefore, while circulating ceramides show great promise as biomarkers, more research is essential to understand their role in disease progression and to translate these findings into clinical practice. For this Special Issue, we accept original articles, reviews, systematic reviews, meta-analyses, and research letters about the role of ceramides in determining adverse cardiovascular and renal events both in clinical and experimental studies.
Dr. Alessandro Mantovani
Guest Editor
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Keywords
- ceramides
- cardiovascular risk
- renal disease
- biomarkers
- sphingolipids
- atherosclerosis
- chronic kidney disease (CKD)
- cardiovascular disease (CVD)
- lipids
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