Mechanistic Insights into Metabolic Interactions with the Tumor Microenvironment
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 71
Special Issue Editor
Interests: cancer research; hormones; cell-death; molecular alterations; cell signaling; tumor microenvironment; cellular plasticity; metabolism and endocrinology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleague,
Metabolic reprogramming within the tumor microenvironment (TME) is a prominent area of research due to its effects on cancer progression, therapy resistance, and the development of new therapeutic targets. The TME is characterized by altered metabolic properties where the different cell subsets, including malignant cells, stromal cells, immune cells, and endothelial cells, affect tumor growth and immune responses. Malignant cells adapt through symbiotic metabolic interactions with other tumor cells to reshape the TME and often shift towards glycolysis (the Warburg effect) or modify fatty acid metabolism. This metabolic switch influences their interaction with surrounding tissues that support tumor growth, immune evasion, and angiogenesis. Meticulously regulated metabolic pathways and their shifting in the TME have become a key focus of the current research, offering promising opportunities for therapeutic targeting and improving preclinical and clinical outcomes.
This Special Issue will feature reviews and original research articles on cutting-edge methods for metabolic profiling in TME, with applications in pathological conditions. It will emphasize studies on metabolomic pathways and their impact on tumor heterogeneity, cell-type switching, peri-neural invasion, and crosstalk molecular mechanism, all with implications for clinical oncology, employing diverse analysis platforms. Therapy resistance remains a critical concern in the field of cancer biology. Additionally, we will highlight how metabolic changes across cells within the TME can impact immune or non-immune cell function, potentially impacting the efficacy of therapies for both cold and hot tumors. Consequently, research that employs metabolomic shifting and related mechanistic insights to understand tumor progression, disease advancement, and drug resistance with the potential to uncover new drug targets will be prioritized.
Dr. Jyoti Kaushal
Guest Editor
Manuscript Submission Information
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Keywords
- metabolism
- tumor microenvironment
- therapy
- immune cells
- clinical oncology
- metabolic pathways
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