Myostatin: A Key Regulator of Skeletal Muscle Metabolism and Development
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Animal Metabolism".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 12
Special Issue Editors
Interests: animal breeding and genetics; molecular markers; cattle; chickens; local breeds; myostatin; biodiversity
Special Issues, Collections and Topics in MDPI journals
Interests: indigenous cattle; animal genetics; gene markers; production traits; genomic selection; myostatin
Special Issue Information
Dear Colleagues,
In the last few years, there has been a growing interest in myostatin, a protein that inhibits the growth and differentiation of muscle tissue. This interest is associated with an increase in the amount of data on the spectrum of myostatin functioning. Myostatin, also known as growth and differentiation factor 8, a member of the transforming growth factor-beta super-family, is a negative regulator of muscle development. Myostatin acts at key points during the pre- and post-natal life of amniotes that ultimately determine the overall muscle mass of an animal.
The molecular pathway driving myogenic myostatin’s influence is currently under extensive study and many molecular partners of myostatin have been identified, suggesting novel potent muscle growth enhancers for both human and agricultural applications.
According to recent investigations, myostatin variants are the main cause of muscular hypertrophy, with minor roles played by other gene variants. Inactivation of myostatin has therefore been proposed as a strategy for improving the muscle growth of livestock and for the treatment of human diseases associated with muscle weakness and dystrophy.
Therefore, based on the role of myostatin in livestock and humans, as well as its involvement in pathological processes, this protein can be considered a promising target in both animal science and in therapeutic studies for humans.
Dr. Emiliano Lasagna
Dr. Ishaku L. Haruna
Guest Editors
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Keywords
- myostatin
- MSTN
- GDF8, muscle development
- muscular hypertrophy
- metabolites and metabolism
- omics sciences
- myostatin pathways
