Autophagy and Antioxidant Pathways in Neurodegenerative Diseases
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 20
Special Issue Editors
Interests: neurodegenerative diseases; autophagy; oxidative stress; microbiota; innate immunity; endocannabinoid system; neuroinflammation; Nrf2-p62/SQSTM1 pathway
Interests: immune system; macrophages; microglia; inflammation; cytokines; chemokines; Alzheimer's disease (AD); atherosclerosis; diet as non-pharmacological treatment for chronic degenerative diseases; ketogenic diet
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The Special Issue “Autophagy and Antioxidant Pathways in Neurodegenerative Diseases” will explore the complex relationship between autophagy mechanisms and antioxidant defense systems in neurodegenerative diseases. Our aim is to provide an advanced understanding of how these biological processes interact, influence disease progression, and offer potential therapeutic strategies. Neurodegenerative diseases are characterized by the progressive degeneration of the nervous system. Research has shown that altered cellular processes, such as autophagy and oxidative stress, are key factors in these diseases. Autophagy failure leads to the accumulation of damaged proteins and organelles, while oxidative stress exacerbates cellular damage, creating a vicious cycle that accelerates disease progression. The role of antioxidants in protecting neurons from oxidative damage and the interaction between autophagy and antioxidant pathways represent an active area of investigation with potential therapeutic targets. This Special Issue will examine the molecular mechanisms by which autophagy and antioxidant systems influence the pathophysiology of neurodegenerative diseases. It is also critical that we explore the therapeutic implications, highlighting strategies that can modulate these pathways to treat or prevent neurodegenerative diseases, including drug development, dietary interventions, and gene therapies.
Authors are invited to explore a broad range of topics, including the molecular and cellular mechanisms behind autophagy and antioxidant pathways, experimental models and innovative technologies to investigate these processes, and clinical relevance with evidence from patient-based studies. Our aim is to encourage collaboration among molecular biologists, neurologists, pharmacologists, and clinicians, promoting translational research and providing a valuable resource for the scientific community by furthering our understanding of the mechanisms behind neurodegenerative diseases and contributing to the development of successful therapies.
Dr. Federica Armeli
Prof. Dr. Rita Businaro
Guest Editors
Manuscript Submission Information
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Keywords
- neurodegeneration
- Alzheimer’s disease
- Parkinson’s disease
- Huntington’s disease
- amyotrophic lateral sclerosis
- autophagy
- neuroinflammation
- oxidative stress
- antioxidant pathways
- neuroprotection
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