Emerging Nanomaterials for Biosensing and Bioimaging

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B1: Biosensors".

Deadline for manuscript submissions: closed (25 September 2023) | Viewed by 1884

Special Issue Editor


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Guest Editor
Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan 8174673461, Iran
Interests: nanotheranostics; medical imaging; diagnosis; cancer therapy; biomedical imaging; molecular imaging; nanomedicine; nuclear medicine; advanced radiation therapy

Special Issue Information

Dear Colleagues,

Biomedical imaging modalities are used for the detection and diagnosis of different types of cancers and diseases in their early stages. Recently, nanomaterials have attracted much attention due to their wide-ranging applications in biomedical imaging and cancer therapy. With the progress made in nanotheranostics (both imaging and therapy agents), studying drugs’ release, accumulation in target tissues, biodistribution, and treatment effectiveness are other subjects devoted attention to.

Nanoparticles are becoming potentially transformative tools for cancer detection for a wide range of biomedical imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI), single-photon emission CT, positron emission tomography (PET), single-photon emission tomography (SPECT), ultrasound, and optical imaging. Knowledge of the correlation between the application of nanoparticles as well as biomedical imaging modalities and the development of targeted nanoprobes may provide better cancer diagnoses in the future.

These imaging modalities may facilitate earlier and more accurate diagnoses in addition to staging of most cancers.

This Special Issue calls for research papers and review articles, attempting to present recent studies on nanotheranostics used as nono-agents in various imaging modalities and platforms for cancer therapy.

Prof. Dr. Daryoush Shahbazi-Gahrouei
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer diagnosis
  • cancer therapy
  • nanoparticles
  • biosensors
  • biomedical imaging

Published Papers (1 paper)

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Research

17 pages, 43342 KiB  
Article
Chitosan–Imidazolium Core–Shell Nanoparticles of Gd-Mn-Mo Polyoxometalate as Novel Potential MRI Nano-Agent for Breast Cancer Detection
by Fahimeh Aminolroayaei, Daryoush Shahbazi-Gahrouei, Mahboubeh Rostami, Seyed Hossein Hejazi and Amin Farzadniya
Micromachines 2023, 14(4), 741; https://doi.org/10.3390/mi14040741 - 27 Mar 2023
Cited by 1 | Viewed by 1614
Abstract
Polyoxometalates (POMs) are mineral nanoclusters with many advantages in various diagnostic fields, in particular cancer detection. This study aimed to synthesize and evaluate the performance of gadolinium–manganese–molybdenum polyoxometalate (Gd-Mn-Mo; POM) nanoparticles coated with chitosan–imidazolium (POM@CSIm NPs) for detecting 4T1 breast cancer cells by [...] Read more.
Polyoxometalates (POMs) are mineral nanoclusters with many advantages in various diagnostic fields, in particular cancer detection. This study aimed to synthesize and evaluate the performance of gadolinium–manganese–molybdenum polyoxometalate (Gd-Mn-Mo; POM) nanoparticles coated with chitosan–imidazolium (POM@CSIm NPs) for detecting 4T1 breast cancer cells by magnetic resonance imaging in vitro and in vivo. The POM@Cs-Im NPs were fabricated and characterized by FTIR, ICP-OES, CHNS, UV–visible, XRD, VSM, DLS, Zeta potential, and SEM. Cytotoxicity, cellular uptake, and MR imaging in vivo and in vitro of L929 and 4T1 cells were also assessed. The efficacy of nanoclusters was demonstrated using MR images of BALB/C mice bearing a 4T1 tumor in vivo. The evaluation of the in vitro cytotoxicity of the designed NPs showed their high biocompatibility. In fluorescence imaging and flow cytometry, NPs had a higher uptake rate by 4T1 than L929 (p < 0.05). Furthermore, NPs significantly increased the signal strength of MR images, and its relaxivity (r1) was calculated as 4.71 mM−1 s−1. MR imaging also confirmed the attachment of nanoclusters to cancer cells and their selective accumulation in the tumor region. Overall, the results showed that fabricated POM@CSIm NPs have considerable potential as an MR imaging nano-agent for early 4T1 cancer detection. Full article
(This article belongs to the Special Issue Emerging Nanomaterials for Biosensing and Bioimaging)
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