Inertial Microfluidics, Volume II

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "E:Engineering and Technology".

Deadline for manuscript submissions: closed (1 June 2022) | Viewed by 2867

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Department of Mechanical Engineering and Oncology, Johns Hopkins University 3400 N Charles St, Latrobe 221, Baltimore, MD 21211, USA
Interests: microfluidics; cell purtification; electroporation; cell engineering; personalized medicine
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Special Issue Information

Dear Colleagues,

During the past decade, inertial microfluidics has been attracting much attention from researchers in diverse fields, including fluid mechanics, bioengineering, and biomedical sciences. The ability of inertial microfluidics to handle fluids and particles with extremely high-throughput has enabled many practical applications such as cell separation/enrichment, flow shaping, single-cell manipulation/analysis, and unconventional microparticle fabrications. Recently, there have been notable increases in publications for the application of inertial microfluidic techniques in bioanalytical research and medical sample collection and diagnostics, yet studies are still being conducted to achieve higher throughput and efficiency in terms of understanding the underlying physics of inertial microfluidics and the development of novel fluid and particle manipulation techniques. This Special Issue seeks original research papers, short communications, and review articles illustrating the capabilities of inertial microfluidic technology not only for fundamental research but also for diverse applications.

We look forward to receiving your contributions.

Dr. Soojung Claire Hur
Guest Editor

Manuscript Submission Information

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Keywords

  • inertial microfluidics
  • finite reflow
  • cell separation
  • inertial focusing
  • single cell analysis
  • microparticle
  • flow cytometer
  • elasto-inertial flow
  • dean flow
  • mixing

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Published Papers (1 paper)

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Research

16 pages, 3179 KiB  
Article
Particle Focusing in a Straight Microchannel with Non-Rectangular Cross-Section
by Uihwan Kim, Joo-Yong Kwon, Taehoon Kim and Younghak Cho
Micromachines 2022, 13(2), 151; https://doi.org/10.3390/mi13020151 - 20 Jan 2022
Cited by 3 | Viewed by 2542
Abstract
Recently, studies on particle behavior under Newtonian and non-Newtonian fluids in microchannel have attracted considerable attention because particles and cells of interest can be manipulated and separated from biological samples without any external force. In this paper, two kinds of microchannels with non-rectangular [...] Read more.
Recently, studies on particle behavior under Newtonian and non-Newtonian fluids in microchannel have attracted considerable attention because particles and cells of interest can be manipulated and separated from biological samples without any external force. In this paper, two kinds of microchannels with non-rectangular cross-section were fabricated using basic MEMS processes (photolithography, reactive ion etching and anisotropy wet etching), plasma bonding and self-alignment between two PDMS structures. They were used to achieve the experiments for inertial and elasto-inertial particle focusing under Newtonian and non-Newtonian fluids. The particle behavior was compared and investigated for different flow rates and particle size in the microchannel with rhombic and equilateral hexagonal cross section. We also investigated the influence of Newtonian fluid and viscoelastic fluid on particle migration in both microchannels through the numerical simulation. The experimental results showed the multi-line particle focusing in Newtonian fluid over a wide range of flow rates, but the single-line particle focusing was formed in the centerline under non-Newtonian fluid. The tighter particle focusing appeared under non-Newtonian fluid in the microchannel with equilateral hexagonal cross-section than in the microchannel with rhombic cross section because of the effect of an obtuse angle. It revealed that particles suspended in the channel are likely to drift toward a channel center due to a negative net elasto-inertial force throughout the cross-sectional area. Simulation results support the present experimental observation that the viscoelastic fluid in the microchannel with rhombic and equilateral hexagonal cross-section significantly influences on the particle migration toward the channel center owing to coupled effect of inertia and elasticity. Full article
(This article belongs to the Special Issue Inertial Microfluidics, Volume II)
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