Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
3.0
Journals
Micromachines
Special Issues
Microfluidic Technologies for Medical Diagnosis and Global Health
share announcement

Microfluidic Technologies for Medical Diagnosis and Global Health

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 7497

Special Issue Editor

Prof. Dr. Wenming Wu

E-Mail Website
Guest Editor
National Engineering Research Center for Health Care Devices, Guangdong Academy of Sciences, Guangzhou, China
Interests: µTAS; immunoassays; biomimetic; digital microfluidics; microbiology; algorithm; optoelectronics; surface modification and bonding technique; micropump; genetics; PCR; microfabrication; MEMS
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ever since our group first introduced the concept of “micro total analysis system—µTAS” in 1990, there has been an explosion of interest in facilitating such miniaturized microfluidic systems for various diagnostic and biomedical point-of-care-test (POCT), covering the detection of HIV/AIDS, tetanus, avian influenza, Ebola virus, malaria, dengue fever, metabolome, pharmaceutics, genetic deficiency, forensic pathology, cancer, toxin monitoring, immunoassays, etc. The microfluidic platform revolutionizes in-field medical diagnosis and has great potential in both developed and developing countries.

In contrast with traditional clinic methodologies, the microfluidic platform displays outstanding advantages due to its diagnostic sensitivity and therapeutic immediacy. With only a small amount of samples, the microfluidic platform can confirm infectious microorganisms and virus pathogens, hereditary and fetation diseases, oncogene mutations and virulent sub-types, and even forensic genetic fingerprints within a few hours/minutes. In this Special Issue, we especially welcome papers in a boundary of technologies aimed at the design, fabrication, and application of microfluidics for medical diagnosis and global health. All types of papers, including short communications, original research papers, and review articles, in these areas are acceptable. Potential microfluidic and multi-disciplinary fields include but are not limited to the following: Genetics, Biochemistry, Materials, Clinical Medicine, Microbiology, Agricultural Sciences, Physical, Neuroscience, Toxicology, Immunology, Manufacture, Lithography, Pharmacology, Algorithm, Optical Engineering, Molecular Biology, Mechatronics，Plant and Animal, etc.

Prof. Dr. Wenming Wu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microchip
  • POCT
  • manufacture
  • clinical medicine
  • heterogeneity
  • immunology
  • genetics
  • pathogens
  • healthcare machinery
  • modeling and simulation
  • optical engineering
  • mechanical and electronic engineering

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

12 pages, 1794 KiB  
Article
Phase-Optimized Peristaltic Pumping by Integrated Microfluidic Logic
by Erik M. Werner, Benjamin X. Lam and Elliot E. Hui
Micromachines 2022, 13(10), 1784; https://doi.org/10.3390/mi13101784 - 20 Oct 2022
Cited by 2 | Viewed by 2246
Abstract
Microfluidic droplet generation typically entails an initial stabilization period on the order of minutes, exhibiting higher variation in droplet volume until the system reaches monodisperse production. The material lost during this period can be problematic when preparing droplets from limited samples such as [...] Read more.
Microfluidic droplet generation typically entails an initial stabilization period on the order of minutes, exhibiting higher variation in droplet volume until the system reaches monodisperse production. The material lost during this period can be problematic when preparing droplets from limited samples such as patient biopsies. Active droplet generation strategies such as antiphase peristaltic pumping effectively reduce stabilization time but have required off-chip control hardware that reduces system accessibility. We present a fully integrated device that employs on-chip pneumatic logic to control phase-optimized peristaltic pumping. Droplet generation stabilizes in about a second, with only one or two non-uniform droplets produced initially. Full article
(This article belongs to the Special Issue Microfluidic Technologies for Medical Diagnosis and Global Health)
►▼ Show Figures

Figure 1

8 pages, 3605 KiB  
Article
Low Cost Three-Dimensional Programmed Mini-Pump Used in PCR
by Chengxiong Lin, Yaocheng Wang, Zhengyu Huang, Yu Guo and Wenming Wu
Micromachines 2022, 13(5), 772; https://doi.org/10.3390/mi13050772 - 14 May 2022
Cited by 2 | Viewed by 2043
Abstract
Programmed mini-pumps play a significant role in various fields, such as chemistry, biology, and medicine, to transport a measured volume of liquid, especially in the current detection of COVID-19 with PCR. In view of the cost of the current automatic pipetting pump being [...] Read more.
Programmed mini-pumps play a significant role in various fields, such as chemistry, biology, and medicine, to transport a measured volume of liquid, especially in the current detection of COVID-19 with PCR. In view of the cost of the current automatic pipetting pump being higher, which is difficult to use in a regular lab, this paper designed and assembled a three-dimensional programmed mini-pump with the common parts and components, such as PLC controller, motor, microinjector, etc. With the weighting calibration before and after pipetting operation, the error of the pipette in 10 μL (0.2%), 2 μL (1.8%), and 1 μL (5.6%) can be obtained. Besides, the contrast test between three-dimensional programmed mini-pump and manual pipette was conducted with the ORF1ab and pGEM-3Zf (+) genes in qPCR. The results proved that the custom-made three-dimensional programmed mini-pump has a stronger reproducibility compared with manual pipette (ORF1ab: 24.06 ± 0.33 vs. 23.50 ± 0.58, p = 0.1014; pGEM-3Zf (+): 11.83.06 ± 0.24 vs. 11.50 ± 0.34, p = 0.8779). These results can lay the foundation for the functional, fast, and low-cost programmed mini-pump in PCR or other applications for trace measurements. Full article
(This article belongs to the Special Issue Microfluidic Technologies for Medical Diagnosis and Global Health)
►▼ Show Figures

Figure 1

Review

Jump to: Research

13 pages, 1146 KiB  
Review
Understanding the Cell’s Response to Chemical Signals: Utilisation of Microfluidic Technology in Studies of Cellular and Dictyostelium discoideum Chemotaxis
by Michael Muljadi, Yi-Chen Fu and Chao-Min Cheng
Micromachines 2022, 13(10), 1737; https://doi.org/10.3390/mi13101737 - 14 Oct 2022
Viewed by 1448
Abstract
Cellular chemotaxis has been the subject of a variety of studies due to its relevance in physiological processes, disease pathogenesis, and systems biology, among others. The migration of cells towards a chemical source remains a closely studied topic, with the Boyden chamber being [...] Read more.
Cellular chemotaxis has been the subject of a variety of studies due to its relevance in physiological processes, disease pathogenesis, and systems biology, among others. The migration of cells towards a chemical source remains a closely studied topic, with the Boyden chamber being one of the earlier techniques that has successfully studied cell chemotaxis. Despite its success, diffusion chambers such as these presented a number of problems, such as the quantification of many aspects of cell behaviour, the reproducibility of procedures, and measurement accuracy. The advent of microfluidic technology prompted more advanced studies of cell chemotaxis, usually involving the social amoeba Dictyostelium discoideum (D. discoideum) as a model organism because of its tendency to aggregate towards chemotactic agents and its similarities to higher eukaryotes. Microfluidic technology has made it possible for studies to look at chemotactic properties that would have been difficult to observe using classic diffusion chambers. Its flexibility and its ability to generate consistent concentration gradients remain some of its defining aspects, which will surely lead to an even better understanding of cell migratory behaviour and therefore many of its related biological processes. This paper first dives into a brief introduction of D. discoideum as a social organism and classical chemotaxis studies. It then moves to discuss early microfluidic devices, before diving into more recent and advanced microfluidic devices and their use with D. discoideum. The paper then closes with brief opinions about research progress in the field and where it will possibly lead in the future. Full article
(This article belongs to the Special Issue Microfluidic Technologies for Medical Diagnosis and Global Health)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop