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Micromachines
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Micro/Nano Systems and Devices for Biomedical Applications: Design, Fabrication and...
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Micro/Nano Systems and Devices for Biomedical Applications: Design, Fabrication and Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 2815

Special Issue Editor

Dr. Kian Jafari

E-Mail Website
Guest Editor
Interdisciplinary Institute for Technological Innovation (3IT), Faculty of Engineering, University of Sherbrooke, Sherbrooke, QC J1K 2R1, Canada
Interests: BioM/NEMS; M/NEMS; emerging micro/nanoelectronics technologies; optical detection approaches

Special Issue Information

Dear Colleagues,

Recent advances in micro and nano engineering have enabled the development of high-performance and reliable systems and devices for various applications in the health and biological domains. These micro/nano systems are relied on in emerging technologies such as M/NEMS, spintronics or novel optical approaches to provide high performances in terms of sensitivity, measurement range and limit of detection for various applications such as point-of-care testing, early diagnosis, drug delivery systems, and DNA sequencing.

This Special Issue focuses on new approaches in the area of micro/nano systems and devices (such as M/NEMS) for biomedical or biological applications. Submissions should span all aspects of the development and application of these systems. Recent advancements in micro and nano engineering and materials have facilitated the creation of high-performance systems and devices catering to diverse applications in the health and biological domains. These micro/nano systems leverage emerging technologies such as M/NEMS, spintronics, or innovative optical approaches to deliver superior performance in terms of sensitivity, measurement range, and limit of detection. This progress is particularly significant for applications such as point-of-care testing, early diagnosis for several disease such as cancer or Alzheimer’s, drug delivery systems, and DNA sequencing.

This Special Issue is dedicated to exploring novel approaches, devices, and systems for biomedical or biological applications on a micro- and nanoscale. This Special Issue will showcase a range of manuscript submissions to cover a broad spectrum of aspects related to the development and application of these cutting-edge systems. In an era marked by a burgeoning demand for precise and efficient solutions in healthcare and biology, the contributions to this Special Issue are expected to provide valuable insights into the evolving landscape of micro and nano technologies. By delving into the intricacies of these advanced systems, researchers aim to pave the way for groundbreaking innovations that hold immense potential for revolutionizing diagnostic tools, therapeutic interventions, and overall healthcare practices.

Dr. Kian Jafari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micro/nano biosystems
  • BioM/NEMS
  • biomedical microsystems
  • emerging technologies for biomedical applications
  • point-of-care testing of micro-nano devices
  • optical technologies and micromirrors for medical instruments
  • drug delivery systems and other sorts of micro or nano systems and devices related to health or biological aspects

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

13 pages, 3513 KiB  
Article
On reactive Ion Etching of Parylene-C with Simple Photoresist Mask for Fabrication of High Porosity Membranes to Capture Circulating and Exfoliated Tumor Cells
by Inad Rabadi, David Carpentieri, Jue Wang, Frederic Zenhausern and Jian Gu
Micromachines 2024, 15(4), 521; https://doi.org/10.3390/mi15040521 - 13 Apr 2024
Viewed by 1143
Abstract
A high porosity micropore arrayed parylene membrane is a promising device that is used to capture circulating and exfoliated tumor cells (CTCs and ETCs) for liquid biopsy applications. However, its fabrication still requires either expensive equipment or an expensive process. Here, we report [...] Read more.
A high porosity micropore arrayed parylene membrane is a promising device that is used to capture circulating and exfoliated tumor cells (CTCs and ETCs) for liquid biopsy applications. However, its fabrication still requires either expensive equipment or an expensive process. Here, we report on the fabrication of high porosity (>40%) micropore arrayed parylene membranes through a simple reactive ion etching (RIE) that uses photoresist as the etching mask. Vertical sidewalls were observed in etched parylene pores despite the sloped photoresist mask sidewalls, which was found to be due to the simultaneous high DC-bias RIE induced photoresist melting and substrate pedestal formation. A theoretical model has been derived to illustrate the dependence of the maximum membrane thickness on the final pore-to-pore spacing, and it is consistent with the experimental data. A simple, yet accurate, low number (<50) cell counting method was demonstrated through counting cells directly inside a pipette tip under phase-contrast microscope. Membranes as thin as 3 μm showed utility for low number tumor cell capture, with an efficiency of 87–92%. Full article
(This article belongs to the Special Issue Micro/Nano Systems and Devices for Biomedical Applications: Design, Fabrication and Applications)
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22 pages, 13911 KiB  
Article
Stereo Visual Servoing Control of a Soft Endoscope for Upper Gastrointestinal Endoscopic Submucosal Dissection
by Jian Chen, Shuai Wang, Qingxiang Zhao, Wei Huang, Mingcong Chen, Jian Hu, Yihe Wang and Hongbin Liu
Micromachines 2024, 15(2), 276; https://doi.org/10.3390/mi15020276 - 15 Feb 2024
Viewed by 1294
Abstract
Quickly and accurately completing endoscopic submucosal dissection (ESD) operations within narrow lumens is currently challenging because of the environment’s high flexibility, invisible collision, and natural tissue motion. This paper proposes a novel stereo visual servoing control for a dual-segment robotic endoscope (DSRE) for [...] Read more.
Quickly and accurately completing endoscopic submucosal dissection (ESD) operations within narrow lumens is currently challenging because of the environment’s high flexibility, invisible collision, and natural tissue motion. This paper proposes a novel stereo visual servoing control for a dual-segment robotic endoscope (DSRE) for ESD surgery. Departing from conventional monocular-based methods, our DSRE leverages stereoscopic imaging to rapidly extract precise depth data, enabling quicker controller convergence and enhanced surgical accuracy. The system’s dual-segment configuration enables agile maneuverability around lesions, while its compliant structure ensures adaptability within the surgical environment. The implemented stereo visual servo controller uses image features for real-time feedback and dynamically updates gain coefficients, facilitating rapid convergence to the target. In visual servoing experiments, the controller demonstrated strong performance across various tasks. Even when subjected to unknown external forces, the controller maintained robust performance in target tracking. The feasibility and effectiveness of the DSRE were further verified through ex vivo experiments. We posit that this novel system holds significant potential for clinical application in ESD surgeries. Full article
(This article belongs to the Special Issue Micro/Nano Systems and Devices for Biomedical Applications: Design, Fabrication and Applications)
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