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Micromachines
Special Issues
Recent Development of Micro/Nanofluidic Devices, 2nd Edition
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Recent Development of Micro/Nanofluidic Devices, 2nd Edition

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "E：Engineering and Technology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 508

Special Issue Editors

Dr. Kailiang Zhang

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Guest Editor
College of Mechanical and Electrical Engineering, Northeast Forestry University, Harbin 150040, China
Interests: microfabrication; lab on a chip; microfluidics; heat and mass transfer; granular sample manipulation; microfluidic sensors
Special Issues, Collections and Topics in MDPI journals
Dr. Yupan Wu

E-Mail Website
Guest Editor
School of Microelectronics, Northwestern Polytechnical University, Xi’an 710072, China
Interests: microfluidics technology; electrokinetic; acoustofluidics; cell manipulation
Special Issues, Collections and Topics in MDPI journals
Dr. Xiangsong Feng

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Guest Editor
Department of Biochemistry and Molecular Biophysics, Columbia University in the City of New York, New York, NY 10027, USA
Interests: fluid mechanics; mass transfer; unsteady state reactors; fluid-fluid reactions; nanoparticle synthesis; sensors and actuators; microfluidics; lab on a chip; microfabrication
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Micro/nanofluidic devices, such as micromixers, microreactors, microseparators, microsprayers, and micro/nanosensors, rely on the integration of multiple physical fields (including flow, electric, magnetic, thermal, optical, and acoustic) to control and manipulate particles or fluids in channels and chambers that typically range in size from hundreds of micrometers down to a few nanometers.

In recent years, such devices have attracted significant attention for their potential in various applications, ranging from biochemical reaction, biosensing, and single-cell analysis to next-generation sequencing, microparticle synthesis, drug delivery, energy harvesting, and sample deposition, among others. One of the most significant advances in micro/nanofluidic devices is the integration of multiple functionalities into a single device, such as the combination of mixing, sensing, and separation, which enables the development of highly miniaturized and portable systems with unprecedented levels of performance.

The rapid advances in materials science and fabrication techniques have further expanded the application of micro/nanofluidic devices. This Special Issue of Micromachines is devoted to recent developments in the modeling, design, and fabrication of novel micro/nanofluidic devices, as well as their practical applications in various contexts. This Special Issue will focus on micro/nanofluidic devices that enable microfluid pumping and mixing; particle/droplet manipulation (e.g., particle sorting, separation, droplet generation, droplet capsule release); small-scale reactions (e.g., particle synthesis, immunodetection, PCR); and cell analysis (such as cell culture, cancer cell screening, and single-cell imaging). While these topics are of particular interest, we welcome all contributions that explore advances in micro/nanofluidics, micro/nanofabrication methods, and their potential applications.

Dr. Kailiang Zhang
Dr. Yupan Wu
Dr. Xiangsong Feng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micromixer
  • microreactor
  • microseparator
  • microsprayer
  • micro/nano sensor
  • micro/nano fabrication
  • droplet manipulation
  • lab on a chip

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Published Papers (1 paper)

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Research

15 pages, 3991 KiB  
Article
Analysis of In Situ Electroporation Utilizing Induced Electric Field at a Wireless Janus Microelectrode
by Haizhen Sun, Linkai Yu, Yifan Chen, Hao Yang and Lining Sun
Micromachines 2024, 15(7), 819; https://doi.org/10.3390/mi15070819 - 25 Jun 2024
Viewed by 394
Abstract
In situ electroporation, a non-invasive technique for enhancing the permeability of cell membranes, has emerged as a powerful tool for intracellular delivery and manipulation. This method allows for the precise introduction of therapeutic agents, such as nucleic acids, drugs, and proteins, directly into [...] Read more.
In situ electroporation, a non-invasive technique for enhancing the permeability of cell membranes, has emerged as a powerful tool for intracellular delivery and manipulation. This method allows for the precise introduction of therapeutic agents, such as nucleic acids, drugs, and proteins, directly into target cells within their native tissue environment. Herein, we introduce an innovative electroporation strategy that employs a Janus particle (JP)-based microelectrode to generate a localized and controllable electric field within a microfluidic chip. The microfluidic device is engineered with an indium tin oxide (ITO)-sandwiched microchannel, where the electric field is applied, and suspended JP microelectrodes that induce a stronger localized electric field. The corresponding simulation model is developed to better understand the dynamic electroporation process. Numerical simulations for both single-cell and chain-assembled cell electroporation have been successfully conducted. The effects of various parameters, including pulse voltage, duration medium conductivity, and radius of Janus microelectrode, on cell membrane permeabilization are systematically investigated. Our findings indicate that the enhanced electric intensity near the poles of the JP microelectrode significantly contributes to the electroporation process. In addition, the distribution for both transmembrane voltage and the resultant nanopores can be altered by conveniently adjusting the relative position of the JP microelectrode, demonstrating a selective and in situ electroporation technique for spatial control over the delivery area. Moreover, the obtained differences in the distribution of electroporation between chain cells can offer insightful directives for the electroporation of tissues or cell populations, enabling the precise and targeted modulation of specific cell populations. As a proof of concept, this work can provide a robust alternative technique for the study of complex and personalized cellular processes. Full article
(This article belongs to the Special Issue Recent Development of Micro/Nanofluidic Devices, 2nd Edition)
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