Microfluidic Chips for Biomedical Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 3472

Special Issue Editors


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Guest Editor
Department of Physics, Fu Jen Catholic University, New Taipei City 242062, Taiwan
Interests: biosensors; microfluidics; surface plasmon resonance; surface coating

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Guest Editor
Department of Biomedical Engineering, Chang Gung University, Taoyuan 333, Taiwan
Interests: microfluidics; biointerfaces; organ-on-chips
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Special Issue Information

Dear Colleagues,

Microfluidics involves the manipulation of fluids in a very small volume, providing precise control over tiny amounts of chemicals, cells, and various biomaterials. Due to the small scale of microfluidic chips, significantly less sample and reagent volumes are required, resulting in cost savings and reduced waste. In addition, microfluidics can perform many experiments in parallel, increasing the throughput and efficiency. Due to these and other unique advantages compared to conventional techniques, microfluidics has been applied to a wide range of biomedical applications. This Special Issue focuses on the latest technical innovations and advancements in microfluidics, with a particular emphasis on biomedical applications. Topics of interest include (but are not limited to) the following:

  • Cell analysis: directed cell migrations such as electrotaxis and chemotaxis;
  • Organ-on-a-chip;
  • Tissue engineering and regenerative medicine;
  • Drug development and screening;
  • Diagnostics and point-of-care testing;
  • Gene sequencing and molecular biology.

We look forward to receiving your submissions.

Prof. Dr. Yung-Shin Sun
Dr. Paul Hsieh-Fu Tsai
Guest Editors

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Keywords

  • microfluidics
  • lab-on-a-chip
  • organ-on-a-chip
  • microfabrication
  • μTAS
  • MEMS

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Published Papers (1 paper)

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Research

13 pages, 2230 KiB  
Article
A Droplet-Based Microfluidic Platform for High-Throughput Culturing of Yeast Cells in Various Conditions
by Min-Chieh Yu and Yung-Shin Sun
Micromachines 2024, 15(8), 1034; https://doi.org/10.3390/mi15081034 - 15 Aug 2024
Viewed by 976
Abstract
Yeast plays a significant role in a variety of fields. In particular, it is extensively used as a model organism in genetics and cellular biology studies, and is employed in the production of vaccines, pharmaceuticals, and biofuels. Traditional “bulk”-based studies on yeast growth [...] Read more.
Yeast plays a significant role in a variety of fields. In particular, it is extensively used as a model organism in genetics and cellular biology studies, and is employed in the production of vaccines, pharmaceuticals, and biofuels. Traditional “bulk”-based studies on yeast growth often overlook cellular variability, emphasizing the need for single-cell analysis. Micro-droplets, tiny liquid droplets with high surface-area-to-volume ratios, offer a promising platform for investigating single or a small number of cells, allowing precise control and monitoring of individual cell behaviors. Microfluidic devices, which facilitate the generation of micro-droplets, are advantageous due to their reduced volume requirements and ability to mimic in vivo micro-environments. This study introduces a custom-designed microfluidic device to encapsulate yeasts in micro-droplets under various conditions in a parallel manner. The results reveal that optimal glucose concentrations promoted yeast growth while cycloheximide and Cu2+ ions inhibited it. This platform enhances yeast cultivation strategies and holds potential for high-throughput single-cell investigations in more complex organisms. Full article
(This article belongs to the Special Issue Microfluidic Chips for Biomedical Applications)
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