Micro/Nanofluidic Devices for Single Cell Analysis, Volume III
A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 18518
Special Issue Editors
Interests: MEMS; Bio-NEMS; single- cell technology; biomedical micro/nano devices; micro/nanofluidics; nanomedicine
Special Issues, Collections and Topics in MDPI journals
Interests: organ on a chip; microfluidic systems; biosensors; CTCs/CTM diagnosis; single cell analysis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cells are the most fundamental building blocks for most life forms and play a significant role in coordinating with one another to perform systematic functions in living creatures. However, the cell-to-cell or cell-to-environment behaviors of cells with their organelles and their intracellular physical/biochemical/biological effects are still unknown. To gain insight into these interactions, the ensemble measurement of millions of cells together cannot provide proper information, such as stem cell proliferation and differentiation, neural network coordination, and cardiomyocyte synchronization. Thus, single-cell analysis has emerged in frontier research in the last few decades. To analyze cellular functions, single-cell analysis (SCA) can be conducted by employing miniaturized devices, whose dimension is similar to that of single cells. Micro-/nanofluidic devices with the power to manipulate and detect biosamples, reagents, or biomolecules at the micro-/nano-scale can well fulfill this requirement for SCA. This analysis can be performed by combining capillary electrophoresis (CE) with laser-induced fluorescence (LIF) detection methods, electrochemical detection (ED), flow cytometry, mass spectrometry, etc., thereby providing specific information about cell interactions with high spatial and temporal resolution. Micro-/nanofluidic devices are not only useful for cell manipulation, cell lysis, and cell separation, but also for easily controlling biochemical, electrical, and mechanical parameters for SCA.
This Special Issue invites manuscripts conducting research on integrated micro- or nanosystems dealing with single-cell manipulation, injection, separation, lysis of single cells, and dynamics of single cells using micro-/nanofluidic devices combined with various detection schemes. The role of SCA is recognized as one of the most important pathways for system biology, proteomics, genomics, metabolomics, and fluxomics and can potentially lead to a paradigm shift. Discussions on the application of SCA for biocatalysis, metabolics, and bioprocess engineering, as well as on the future challenges for SCA and its advantages and limitations, are also welcome.
Dr. Tuhin Subhra Santra
Prof. Dr. Fan-Gang Tseng
Guest Editors
Manuscript Submission Information
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Keywords
- Lab on a chip
- Life on a chip
- Organ on a chip
- Lab in a cell
- Cell chip
- Micro total analysis (µTAS)
- Microfluidics
- Nanofluidics
- Single-cell perturbation
- Single-cell cultivation
- Single-cell proteomics
- Single-cell interaction
- Dielectrophoresis
- Electrophoresis
- Optical trapping
- Capillary electrophoresis
- Electroporation
- Flow cytometry
- Heterogeneity
- Mechanical characterization
- Optical characterization
- Biochemical characterization
- System biology
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