The Vaginal Microbiome in Health and Disease

Dear Colleagues,

Vaginal microbe-related research explores the complex ecosystem of microorganisms residing in the vaginal tract and their impact on women’s health. This field has gained significant attention due to the vital role the vaginal microbiota plays in protecting against infections, maintaining vaginal health, and its potential links to various gynecological and obstetric outcomes.

The predominant bacteria in a healthy vaginal microbiome are Lactobacillus species, which produce lactic acid to maintain a low pH, creating an inhospitable environment for pathogenic bacteria. Disruptions in this balance, known as dysbiosis, can lead to conditions such as bacterial vaginosis, which is associated with increased risks of sexually transmitted infections, pelvic inflammatory disease, and adverse pregnancy outcomes like preterm birth.

Recent advances in high-throughput sequencing technologies and metagenomics have allowed researchers to comprehensively profile the vaginal microbiome, uncovering its diversity and dynamic nature. These studies aim to identify microbial signatures linked to specific health conditions and understand the mechanisms through which microbes influence vaginal health.

Ongoing research focuses on developing probiotics and other microbiome-based therapies to restore and maintain a healthy vaginal microbiota. Additionally, there is growing interest in personalized medicine approaches that consider individual microbiome compositions to tailor treatments and improve women’s reproductive health outcomes.

This Special Issue will focus on the latest research on the impact of vaginal flora on gynecological and obstetric conditions, exploring their pathogenesis and potential therapeutic approaches.

Dr. Zohar Nachum
Dr. Enav Yefet
Guest Editors

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• vaginal flora
• pathogenesis
• therapeutic approaches
• health