Diet, Supplements, Lifestyle and Human Microbiota: Impacts on Health and Disease

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbiomes".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 852

Special Issue Editors


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Guest Editor
Gastroenterology Unit IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo, Italy
Interests: microbiota; gene expression; gastroenterology; pancreatic diseases; liver diseases
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Dietetic and Clinical Nutrition Unit, City of Health and Science University Hospital, 10126 Turin, Italy
Interests: clinical nutrition; microbiota

Special Issue Information

Dear Colleagues,

The human microbiota, a complex ecosystem of microorganisms residing in the gastrointestinal tract and other districts of the human body, has a crucial role in maintaining health and influencing disease. Recent research has highlighted the significant impact of diet, supplements, and lifestyle on the composition and function of the microbiota, with profound implications for a wide array of clinical conditions. This Special Issue, "Diet, Supplements, Lifestyle and Human Microbiota: Impacts on Health and Disease", aims to explore these dynamic interactions and provide a comprehensive understanding of how targeted interventions can promote well-being and prevent diseases.

In this Special Issue, we will consider articles and case reports that explore the interactions between diet, supplements, and lifestyle and their impact on the human microbiota. By delving into these topics, we aim to highlight the potential of integrative approaches to enhance health and mitigate disease through the modulation of the microbiota.

Dr. Valerio Pazienza
Dr. Concetta Finocchiaro
Guest Editors

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Keywords

  • human microbiome
  • dysbiosis
  • cancer
  • vaginal microbiota
  • sport
  • nutrition
  • lifestyle
  • pathological condition
  • infertility
  • IVF

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Published Papers (1 paper)

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Research

16 pages, 1104 KiB  
Article
Gut Microbiota Alterations in Alzheimer’s Disease: Relation with Cognitive Impairment and Mediterranean Lifestyle
by David Mateo, Nerea Carrión, Cristian Cabrera, Luis Heredia, Montse Marquès, Eva Forcadell-Ferreres, Maria Pino, Josep Zaragoza, Alfons Moral, Lluís Cavallé, José M. González-de-Echávarri, Paloma Vicens, José L. Domingo and Margarita Torrente
Microorganisms 2024, 12(10), 2046; https://doi.org/10.3390/microorganisms12102046 - 10 Oct 2024
Viewed by 663
Abstract
Recently, an association between dysbiosis of the gut microbiota (GMB) and the development of several diseases, such as Alzheimer’s disease (AD), has been proposed. Dysbiosis involves changes in microbial diversity influenced by environmental factors, like diet or lifestyle. In this study, we investigated [...] Read more.
Recently, an association between dysbiosis of the gut microbiota (GMB) and the development of several diseases, such as Alzheimer’s disease (AD), has been proposed. Dysbiosis involves changes in microbial diversity influenced by environmental factors, like diet or lifestyle. In this study, we investigated the role of GMB parameters in Spanish AD patients, assessing the impact of adherence to the Mediterranean lifestyle (ML), as well as to characterize these parameters in relation to neuropsychological, neuropsychiatric, emotional, and functionality parameters. A case–control study was conducted to investigate the association between the composition of the GMB and cognitive, emotional, neuropsychiatric, and functionality status in Spanish AD patients, along with a shotgun metagenomics approach. Richness and alpha-diversity were significantly lower in the AD group compared to the controls. PERMANOVA and ANOSIM tests of Bray–Curtis dissimilarity, Aitchison distance, and Jaccard similarity did not showed significant differences in beta-diversity between the two groups. Moreover, associations between various phyla of the AD group and orientation performance, food consumption, and activities of daily living were identified. Dysbiosis observed in Spanish AD patients is characterized by reductions in richness and alpha-diversity, alongside alterations in GMB composition, which may be linked to adherence to the ML and cognitive and functionality symptoms. Full article
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