Microbiome and Pneumonia
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".
Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 1432
Special Issue Editors
Interests: pneumonia; microbiome; gut-lung axis; dysbiosis; viral infection; asthma; chronic respiratory pulmonary disease
Special Issues, Collections and Topics in MDPI journals
Interests: clinical infectious diseases; surgical site infection; influenza; microbiome
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Despite the advances in diagnostic methods and antibiotic therapy, pneumonia is the world's leading cause of death due to infection. Moreover, the emergence of drug-resistant pathogens such as carbapenem-resistant Enterobacteriaceae is a global issue.
Although lungs used to be considered sterile organs, there is plenty of evidence of existing microorganisms in lungs that can correlate with the pathogenesis and development of chronic lung diseases, such as asthma, chronic obstructive pulmonary disease, interstitial lung disease, lung cancer, etc. Recent studies have shown that the gut microbiome affects an immune response in pneumonia. The gut dysbiosis that can be caused by lung dysbiosis mutually, which is called the gut–lung axis, contributes to the severity of pneumonia and clinical outcome. Furthermore, gut dysbiosis can contribute to decreasing antibody production after pneumococcal vaccination among allergic patients, such as severe atopic dermatitis. This issue might have impacted the high mortality rate of invasive pneumococcal disease, even though the patients were vaccinated with the pneumococcal vaccine. Modulating the dysbiosis in the lung and gut can be an essential treatment for pneumonia to improve the outcomes in patients with dysbiosis conditions. This review focuses on how the microbiome affects pneumonia's pathogenesis and clinical outcomes.
Dr. Nobuhiro Asai
Dr. Hiroshige Mikamo
Guest Editors
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Keywords
- pneumonia
- microbiome
- gut-lung axis
- dysbiosis
- viral infection
- asthma
- chronic respiratory pulmonary disease
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