Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.4
4.1
Journals
Microorganisms
Special Issues
Intestinal Probiotics
share announcement

Intestinal Probiotics

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 4974

Special Issue Editors

Prof. Dr. Xiaoxi Xu

E-Mail Website
Guest Editor
College of Food Science, Northeast Agricultural University, Harbin 150030, China
Interests: gut microbes; human health
Dr. Yanfeng Tuo

E-Mail Website
Guest Editor
School of Food Science and Technology, Dalian Polytechnic University, Dalian, China
Interests: probiotics; lactic acid bacteria

Special Issue Information

Dear Colleagues,

Intestinal probiotics have an important regulatory role in regulating intestinal homeostasis and the direction of human health. Intestinal probiotics can adjust the structural homeostasis of intestinal flora and achieve immune regulation to fight inflammation as well as regulate cancer and some diseases. A new coronavirus infection leads to intestinal flora disorder, which seriously affects human health and quality of life; therefore, it is crucial to investigate the specific functions of intestinal probiotics in order to clarify the interactions between prebiotics and intestinal probiotics as well as investigate the community effect patterns among intestinal probiotics in addition to the functional roles of their derived active metabolites, such as bacteriophage peptidoglycan and bacterial extracellular vesicles. This Special Issue aims to further expand the functional utilization of intestinal probiotics by collecting more high-quality articles on research developments in this field.

In this Special Issue, original research articles and reviews are welcome. We look forward to receiving your contributions.

Prof. Dr. Xiaoxi Xu
Dr. Yanfeng Tuo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • intestinal flora
  • probiotics
  • prebiotics
  • synbiotics
  • bacterial extracellular vesicles
  • population effect
  • intestinal immunity
  • human health

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

15 pages, 614 KiB  
Article
Effect of Agroindustrial Waste Substrate Fermented with Lactic Acid Bacteria and Yeast on Changes in the Gut Microbiota of Guinea Pigs
by José Miranda-Yuquilema, Juan Taboada, Verónica Once, Marco Coyago and Wilfrido Briñez
Microorganisms 2024, 12(1), 133; https://doi.org/10.3390/microorganisms12010133 - 10 Jan 2024
Cited by 2 | Viewed by 1484
Abstract
The aim of the study was to evaluate the impact of probiotics obtained from an agroindustrial waste substrate fermented with lactic acid bacteria and/or yeasts on the health and changes in the microbiota of the digestive tract of guinea pigs. Eighty male guinea [...] Read more.
The aim of the study was to evaluate the impact of probiotics obtained from an agroindustrial waste substrate fermented with lactic acid bacteria and/or yeasts on the health and changes in the microbiota of the digestive tract of guinea pigs. Eighty male guinea pigs, Kuri breed, 30 days old and 250 g live weight, were randomly selected and divided into four groups of 20 animals each: T0, control; T1, Lactobacillus acidophilus and L. bulgaricus; T2, Saccharomyces cerevisiae and Kluyveromyces fragilis; and T3. L. acidophilus, L. bulgariccus, S. cerevisiae and K. fragilis. T1, T2 and T3 contained molasses-vinasse substrate in their base, the dose administered was 1.00 mL/animal orally every 3 days. The indicators evaluated were weight gain, occurrence of diarrhea and mortality, macroscopic lesions in the digestive tract organs and changes in the microbiota of the stomach, caecum, small and large intestine. Treatments T1, T2 and T3 improved weight gain (p < 0.05) and reduced the presence of guinea pigs with diarrhea (p < 0.05) and there was no mortality; animals in the control group presented a greater amount (p < 0.05) of macroscopic lesions in the digestive tract organs; in the T1, T2 and T3 groups there was an improvement in the natural microbiota. It is concluded that the inclusion of a microbial additive in young guinea pigs improves intestinal health and consequently improves weight gain, reduces diarrhea and deaths and normalizes the natural microbiota of the gastrointestinal tract. Full article
(This article belongs to the Special Issue Intestinal Probiotics)
►▼ Show Figures

Figure 1

14 pages, 1762 KiB  
Article
2-Fucosyllactose Metabolism by Bifidobacteria Promotes Lactobacilli Growth in Co-Culture
by Alicja M. Nogacka, Isabel Cuesta, Miguel Gueimonde and Clara G. de los Reyes-Gavilán
Microorganisms 2023, 11(11), 2659; https://doi.org/10.3390/microorganisms11112659 - 29 Oct 2023
Cited by 2 | Viewed by 1816
Abstract
Breastfeeding is recognized as the gold standard in infant nutrition, not only because of breastmilk’s intrinsic nutritional benefits but also due to the high content of different bioactive components such as 2-fucosyllactose (2′FL) in the mother’s milk. It promotes the growth of its [...] Read more.
Breastfeeding is recognized as the gold standard in infant nutrition, not only because of breastmilk’s intrinsic nutritional benefits but also due to the high content of different bioactive components such as 2-fucosyllactose (2′FL) in the mother’s milk. It promotes the growth of its two major consumers, Bifidobacterium longum ssp. infantis and Bifidobacterium bifidum, but the effect on other intestinal microorganisms of infant microbiota remains incompletely understood. pH-uncontrolled fecal cultures from infants donors identified as “fast 2′FL -degrader” microbiota phenotype were used for the isolation of 2′FL-associated microorganisms. The use of specific selective agents allowed the successful isolation of B. bifidum IPLA20048 and of Lactobacillus gasseri IPLA20136. The characterization of 2′FL consumption and its moieties has revealed more pronounced growth, pH drop, and lactic acid production after 2′FL consumption when both microorganisms were grown together. The results point to an association between B. bifidum IPLA20048 and L. gasseri IPLA20136 in which L. gasseri is able to use the galactose from the lactose moiety after the hydrolysis of 2′FL by B. bifidum. The additional screening of two groups of bifidobacteria (n = 38), fast and slow degraders of 2′FL, in co-culture with lactobacilli confirmed a potential cross-feeding mechanism based on degradation products released from bifidobacterial 2′FL break-down. Our work suggests that this phenomenon may be widespread among lactobacilli and bifidobacteria in the infant gut. More investigation is needed to decipher how the ability to degrade 2′FL and other human milk oligosaccharides could influence the microbiota establishment in neonates and the evolution of the microbiota in adult life. Full article
(This article belongs to the Special Issue Intestinal Probiotics)
►▼ Show Figures

Graphical abstract

19 pages, 28376 KiB  
Article
Loss in the Antibacterial Ability of a PyrR Gene Regulating Pyrimidine Biosynthesis after Using CRISPR/Cas9-Mediated Knockout for Metabolic Engineering in Lactobacillus casei
by Shaojun Chen, Xinmiao He, Ziliang Qin, Gang Li, Wentao Wang, Zida Nai, Yaguang Tian, Di Liu and Xinpeng Jiang
Microorganisms 2023, 11(10), 2371; https://doi.org/10.3390/microorganisms11102371 - 22 Sep 2023
Cited by 2 | Viewed by 1353
Abstract
Lactobacillus casei (L. casei) has four possible mechanisms: antimicrobial antagonism, competitional adhesion, immunoregulation, and the inhibition of bacterial toxins. To delineate the metabolic reactions of nucleotides from L. casei that are associated with mechanisms of inhibiting pathogens and immunoregulation, we report [...] Read more.
Lactobacillus casei (L. casei) has four possible mechanisms: antimicrobial antagonism, competitional adhesion, immunoregulation, and the inhibition of bacterial toxins. To delineate the metabolic reactions of nucleotides from L. casei that are associated with mechanisms of inhibiting pathogens and immunoregulation, we report that a PyrR-deficient L. casei strain was constructed using the CRISPR-Cas9D10A tool. Furthermore, there were some changes in its basic biological characterization, such as its growth curve, auxotroph, and morphological damage. The metabolic profiles of the supernatant between the PyrR-deficient and wild strains revealed the regulation of the synthesis of genetic material and of certain targeting pathways and metabolites. In addition, the characteristics of the PyrR-deficient strain were significantly altered as it lost the ability to inhibit the growth of pathogens. Moreover, we identified PyrR-regulating pyrimidine biosynthesis, which further improved its internalization and colocalization with macrophages. Evidence shows that the PyrR gene is a key active component in L. casei supernatants for the regulation of pyrimidine biosynthesis against a wide range of pathogens. Full article
(This article belongs to the Special Issue Intestinal Probiotics)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop