Probiotics, Gut Microbiota, and Health

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 559

Special Issue Editors


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Guest Editor
Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Roma, Italy
Interests: antibiotics; PCR; bacteriology; microbial molecular biology; antimicrobial resistance; gel electrophoresis; general microbiology; DNA extraction; electrophoresis; DNA
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Guest Editor
Department of Clinical Medicine and Public Health, University of L'Aquila, L'Aquila, Italy
Interests: probiotics; human gut microflora
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the past decade, a wealth of research has highlighted the beneficial effects of probiotics in favoring a balanced microbiota and gastrointestinal (GI) health, but this represents only the tip of the iceberg. In this context, studies deepening our understanding of how probiotic microorganisms influence the composition and metabolic or immunological activities of the human gut microbiota are paramount, particularly in the context of preventing and managing chronic diseases, with special attention to vulnerable populations such as infants, pregnant women, and the elderly.

For this Special Issue, titled “Probiotics, Gut Microbiota, and Health”, we invite researchers to submit high-quality original research articles and comprehensive narrative and systematic reviews exploring the multifaceted impact of probiotics on gut health and human diseases. We welcome studies encompassing clinical, in vivo, and in vitro investigations that delve into the bioactive effects, underlying mechanisms, and therapeutic applications of probiotics.

Dr. Massimiliano Marazzato
Prof. Dr. Claudio de Simone
Guest Editors

Manuscript Submission Information

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Keywords

  • probiotic
  • gut microbiota
  • intestinal microbiome
  • host health

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Published Papers (1 paper)

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Review

26 pages, 2080 KB  
Review
Therapeutic Potential of Probiotics in Metabolic Dysfunction-Associated Steatohepatitis: A Comprehensive Review
by Xueying Wang, Zhiying Wei, Qing Xiang, Lijie Tang and Weichun Xie
Microorganisms 2025, 13(8), 1894; https://doi.org/10.3390/microorganisms13081894 - 14 Aug 2025
Viewed by 448
Abstract
Metabolic dysfunction-associated steatohepatitis (MASH) constitutes a significant and progressive liver disease, characterized by a complex pathogenesis that involves dysbiosis of the gut microbiota. While the multifaceted nature of MASH is widely recognized, its underlying mechanisms remain the subject of active investigation. Contemporary research [...] Read more.
Metabolic dysfunction-associated steatohepatitis (MASH) constitutes a significant and progressive liver disease, characterized by a complex pathogenesis that involves dysbiosis of the gut microbiota. While the multifaceted nature of MASH is widely recognized, its underlying mechanisms remain the subject of active investigation. Contemporary research highlights the critical role of the gut–liver axis, suggesting that disturbances in the gut microbiome may contribute to the progression of the disease. Probiotics have notably emerged as a promising therapeutic approach for MASH, with the potential to modulate the gut microbiome and mitigate symptoms. This review aims to examine the alterations in the gut microbiome associated with MASH pathogenesis, the interaction of probiotics with the gut–liver axis, and their significance in the development and management of MASH. By synthesizing current evidence on the mechanisms of action of probiotics, clinical trials, and comparative efficacy of different strains, as well as existing controversies, challenges, and future research directions, this review seeks to establish a scientific foundation for probiotic-based interventions as an innovative therapeutic strategy for MASH. Full article
(This article belongs to the Special Issue Probiotics, Gut Microbiota, and Health)
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