Advances in Herpesvirus Infection

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Virology".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 3338

Special Issue Editors


E-Mail Website
Guest Editor
School of Medicine, Zhejiang University, Hangzhou, China
Interests: herpes virology

E-Mail Website
Guest Editor
Department of Microbiology Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada
Interests: antiviral innate immunity; viral immune evasion mechanism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue on Advances in Herpesvirus Infection.

Alphaherpesviruses are neurotropic viruses that include common human pathogens herpes simplex virus 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV). These viruses switch between two programs of infection: lytic infection and latent infection. Lytic infection causes various diseases, while latent infection enables immune evasion. Recent research contributes greatly to understanding how these viruses replicate and cause disease, how they switch between lytic and latent infection, and whether we can better control diseases caused by these viruses.

This Special Issue aims to highlight recent advances in alphaherpesvirus research and promote communication within this field. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Alphaherpesvirus replication cycle.
  • Alphaherpesvirus latency and reactivation.
  • Alphaherpesvirus–host interactions.
  • Pathogenesis and immunity during alphaherpesvirus infection.
  • Alphaherpesvirus disease treatment and prevention.

I/We look forward to receiving your contributions.

Prof. Dr. Dongli Pan
Dr. Chunfu Zheng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • alphaherpesvirus
  • herpes simplex virus
  • varicella-zoster virus
  • HSV-1
  • HSV-2
  • VZV

Published Papers (1 paper)

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Review

15 pages, 1618 KiB  
Review
Bacterial-Artificial-Chromosome-Based Genome Editing Methods and the Applications in Herpesvirus Research
by Mengling Hao, Jiabao Tang, Shengxiang Ge, Tingdong Li and Ningshao Xia
Microorganisms 2023, 11(3), 589; https://doi.org/10.3390/microorganisms11030589 - 26 Feb 2023
Cited by 3 | Viewed by 2765
Abstract
Herpesviruses are major pathogens that infect humans and animals. Manipulating the large genome is critical for exploring the function of specific genes and studying the pathogenesis of herpesviruses and developing novel anti-viral vaccines and therapeutics. Bacterial artificial chromosome (BAC) technology significantly advanced the [...] Read more.
Herpesviruses are major pathogens that infect humans and animals. Manipulating the large genome is critical for exploring the function of specific genes and studying the pathogenesis of herpesviruses and developing novel anti-viral vaccines and therapeutics. Bacterial artificial chromosome (BAC) technology significantly advanced the capacity of herpesviruses researchers to manipulate the virus genomes. In the past years, advancements in BAC-based genome manipulating and screening strategies of recombinant BACs have been achieved, which has promoted the study of the herpes virus. This review summarizes the advances in BAC-based gene editing technology and selection strategies. The merits and drawbacks of BAC-based herpesvirus genome editing methods and the application of BAC-based genome manipulation in viral research are also discussed. This review provides references relevant for researchers in selecting gene editing methods in herpes virus research. Despite the achievements in the genome manipulation of the herpes viruses, the efficiency of BAC-based genome manipulation is still not satisfactory. This review also highlights the need for developing more efficient genome-manipulating methods for herpes viruses. Full article
(This article belongs to the Special Issue Advances in Herpesvirus Infection)
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