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Microorganisms
Special Issues
Microbial Impact on Cholesterol and Bile Acid Metabolism 2.0
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Microbial Impact on Cholesterol and Bile Acid Metabolism 2.0

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 5209

Special Issue Editor

Dr. Jason Ridlon

E-Mail Website
Guest Editor
410 Animal Sciences Laboratory, Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA
Interests: coprostanol; deoxycholic acid; Clostridium difficile; cholesterol; bile acid; microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our previous special issue “Microbial Impact on Cholesterol and Bile Acid Metabolism”.

The metabolism of cholesterol and bile acids by the gut microbiota represent processes important in both health and disease. The conversion of cholesterol to coprostanol by gut bacteria has been a challenging area of research for some time but promises to advance our ability to modulate serum cholesterol levels in the host. Bile acids are synthesized from cholesterol in the liver and function to solubilize cholesterol and other lipids in the small intestine. Bile acid metabolism by gut bacteria represents another microbial target for altering host cholesterol levels. In addition, bile acid biotransformations affect the microbiome structure, colonization by pathogens, host signaling through nuclear and G-protein-coupled receptors, and the risk for chronic diseases. The objective of this Special Issue of Microorganisms is to present the current understanding of the microbial biotransformations of bile acids and cholesterol and to describe how these processes affect microbial and host physiology, chronic disease, and infection by pathogenic bacteria and viruses.

Dr. Jason Ridlon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coprostanol
  • deoxycholic acid
  • Clostridium difficile
  • cholesterol
  • bile acid
  • microbiome

Published Papers (2 papers)

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Review

14 pages, 1827 KiB  
Review
The Role of Gut Microbiota-Derived Lithocholic Acid, Deoxycholic Acid and Their Derivatives on the Function and Differentiation of Immune Cells
by Yoshimitsu Kiriyama and Hiromi Nochi
Microorganisms 2023, 11(11), 2730; https://doi.org/10.3390/microorganisms11112730 - 8 Nov 2023
Cited by 5 | Viewed by 2199
Abstract
A wide variety and large number of bacterial species live in the gut, forming the gut microbiota. Gut microbiota not only coexist harmoniously with their hosts, but they also induce significant effects on each other. The composition of the gut microbiota can be [...] Read more.
A wide variety and large number of bacterial species live in the gut, forming the gut microbiota. Gut microbiota not only coexist harmoniously with their hosts, but they also induce significant effects on each other. The composition of the gut microbiota can be changed due to environmental factors such as diet and antibiotic intake. In contrast, alterations in the composition of the gut microbiota have been reported in a variety of diseases, including intestinal, allergic, and autoimmune diseases and cancer. The gut microbiota metabolize exogenous dietary components ingested from outside the body to produce short-chain fatty acids (SCFAs) and amino acid metabolites. Unlike SCFAs and amino acid metabolites, the source of bile acids (BAs) produced by the gut microbiota is endogenous BAs from the liver. The gut microbiota metabolize BAs to generate secondary bile acids, such as lithocholic acid (LCA), deoxycholic acid (DCA), and their derivatives, which have recently been shown to play important roles in immune cells. This review focuses on current knowledge of the role of LCA, DCA, and their derivatives on immune cells. Full article
(This article belongs to the Special Issue Microbial Impact on Cholesterol and Bile Acid Metabolism 2.0)
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18 pages, 1295 KiB  
Review
The Crosstalk between Gut Microbiota and Bile Acids Promotes the Development of Non-Alcoholic Fatty Liver Disease
by Zhonglin Li, Hang Yuan, Huikuan Chu and Ling Yang
Microorganisms 2023, 11(8), 2059; https://doi.org/10.3390/microorganisms11082059 - 11 Aug 2023
Cited by 2 | Viewed by 2473
Abstract
Recently the roles of gut microbiota are highly regarded in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The intestinal bacteria regulate the metabolism of bile acids depending on bile salt hydrolase (BSH), 7-dehydroxylation, hydroxysteroid dehydrogenase (HSDH), or amide conjugation reaction, thus exerting [...] Read more.
Recently the roles of gut microbiota are highly regarded in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The intestinal bacteria regulate the metabolism of bile acids depending on bile salt hydrolase (BSH), 7-dehydroxylation, hydroxysteroid dehydrogenase (HSDH), or amide conjugation reaction, thus exerting effects on NAFLD development through bile acid receptors such as farnesoid X receptor (FXR), Takeda G-protein-coupled bile acid protein 5 (TGR5), and vitamin D receptor (VDR), which modulate nutrient metabolism and insulin sensitivity via interacting with downstream molecules. Reversely, the composition of gut microbiota is also affected by the level of bile acids in turn. We summarize the mutual regulation between the specific bacteria and bile acids in NAFLD and the latest clinical research based on microbiota and bile acids, which facilitate the development of novel treatment modalities in NAFLD. Full article
(This article belongs to the Special Issue Microbial Impact on Cholesterol and Bile Acid Metabolism 2.0)
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