Regulation and Functions of RNA Exonucleases in Bacteria
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 3648
Special Issue Editor
Special Issue Information
Dear Colleagues,
RNA endo- and exonucleases (collectively referred to as ribonucleases, RNases) play fundamental roles in all kinds of cells. Indeed, they modulate the intracellular concentration of different RNA transcripts, thus contributing to gene expression regulation. Moreover, they provide the cells with mature and functional RNA molecules and contribute to recycling nucleotides.
The aim of this Special Issue is to advance the knowledge of hydrolytic and phosphorolytic exoribonucleases (exoRNases) of bacteria by collecting research articles, short communications, and reviews about their regulation and function. Extensive studies performed in the last four decades have allowed us to understand the fundamental aspects of the function of these enzymes, of their interaction with other cellular factors, and of the processes in which they are involved. However, important questions remain about the regulation of the expression of exoRNase-encoding genes and of the intracellular localization of exoRNases. Unclear are also the rules and mechanisms governing their specificity and activity so that they can extensively digest some RNAs and process others by accurately removing precise RNA portions. Moreover, RNA processing and degradation have mainly been studied in a few model species. It would be important to enlarge the analysis to other bacteria to get a more comprehensive understanding of the conservation and divergence of these processes in the branches of the bacterial phylogenetic tree.
Dr. Federica Briani
Guest Editor
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Keywords
- RNase
- PNPase
- RNA degradation
- RNA processing
- RNA degradosome
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