Bacterial Quorum Sensing (QS)

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3627

Special Issue Editor


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Guest Editor
Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
Interests: bacterial virulence and quorum sensing; microbial resistance; antimicrobial nano-preparations

Special Issue Information

Dear Colleagues,

The discovery of microbial communication through quorum sensing (QS) is considered one of the major advances in science. Microbial cells can communicate via quorum signals known as autoinducers or pheromones. Several mechanisms encountered in QS have been described. Quorum sensing machinery controls the secretion of an arsenal of enzymes, proteins, and polysaccharides. Moreover, QS is considered one of the major contributors to the expression of microbial virulence factors, biofilm assembly, host colonization, and evasion. In addition, cellular behavior in the presence of invaders is also controlled by QS circuits.

Quorum sensing inhibition (QSI) is an attractive approach for the development of novel antipathogenic therapies as it disrupts bacterial pathogenic activities without killing the pathogen and facilitates microbial eradication via the immune system.

This Special Issue will provide a collection of articles that display new findings on how microorganisms communicate and how they interact through quorum sensing circuits, as well as how the QSI can influence microbial infection and dissemination. I invite you to submit research articles, review articles, and short communications related to quorum sensing along with new advances in quorum sensing inhibitors.

The main topics of interest include:

  • Novel genes in QS circuits
  • New approaches in QS
  • QS and ecosystem
  • QS and metabolites production.
  • QS and microbial virulence
  • Novel synthetic or natural QSI
  • In vitro and in vivo applications of QSI
  • QSI via nanomaterials

Dr. Mona I. Shaaban
Guest Editor

Manuscript Submission Information

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Keywords

  • quorum sensing
  • quorum sensing inhibition
  • cell–cell communication
  • autoinducers
  • cell signaling
  • quorum quenching
  • microbial virulence
  • biofilm

Published Papers (1 paper)

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Research

13 pages, 4396 KiB  
Article
Carvacrol Inhibits Quorum Sensing in Opportunistic Bacterium Aeromonas hydrophila
by Liushen Lu, Junwei Wang, Ting Qin, Kai Chen, Jun Xie and Bingwen Xi
Microorganisms 2023, 11(8), 2027; https://doi.org/10.3390/microorganisms11082027 - 7 Aug 2023
Cited by 3 | Viewed by 2148
Abstract
Bacterial quorum sensing (QS) plays a crucial role in chemical communication between bacteria involving autoinducers and receptors and controls the production of virulence factors in bacteria. Therefore, reducing the concentration of signaling molecules in QS is an effective strategy for mitigating the virulence [...] Read more.
Bacterial quorum sensing (QS) plays a crucial role in chemical communication between bacteria involving autoinducers and receptors and controls the production of virulence factors in bacteria. Therefore, reducing the concentration of signaling molecules in QS is an effective strategy for mitigating the virulence of pathogenic bacteria. In this study, we demonstrated that carvacrol at 15.625 μg/mL (1/4 MIC), a natural compound found in plants, exhibits potent inhibitory activity against QS in Chromobacterium violaceum, as evidenced by a significant reduction (62.46%) in violacein production. Based on its impressive performance, carvacrol was employed as a natural QS inhibitor to suppress the pathogenicity of Aeromonas hydrophila NJ-35. This study revealed a significant reduction (36.01%) in the concentration of N-acyl-homoserine lactones (AHLs), a QS signal molecular secreted by A. hydrophila NJ-35, after 1/4 MIC carvacrol treatment. Moreover, carvacrol was found to down-regulate the expression of ahyR/I, two key genes in the QS system, which further inhibited the QS system of A. hydrophila NJ-35. Finally, based on the above results and molecular docking, we proposed that carvacrol alleviate the pathogenicity of A. hydrophila NJ-35 through QS inhibition. These results suggest that carvacrol could serve as a potential strategy for reducing the virulence of pathogenic bacteria and minimizing the reliance on antibiotics in aquaculture. Full article
(This article belongs to the Special Issue Bacterial Quorum Sensing (QS))
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