Recent Advances in Understanding Epstein-Barr Virus
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Virology".
Deadline for manuscript submissions: closed (31 March 2019) | Viewed by 21429
Special Issue Editors
Interests: microbial pathogenesis (HIV, EBV, H. pylori); infection associated cancers
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Special Issue Information
Dear Colleagues,
The Epstein-Barr virus (EBV) is a human gamma-herpesvirus and more than 90% of population is infected with the virus. EBV infects with oropharyngeal naïve B lymphocytes through saliva then spread to the adjacent B lymphocytes and epithelial cells. Immunological maturation of infected host divides initial infections to asymptomatic infection in infancy and infectious mononucleosis in adolescence. The initial productive lytic infection will shift to persistent latent infection, where limited viral transcripts are expressed to support persistent infection. In most of the cases, EBV associates with the infected person without any symptoms during the person’s life. Primarily resting memory B lymphocytes in peripheral blood provide a permanent reservoir for the virus. However, EBV sometimes shifts from latent to lytic infection in association with local or systemic immunological suppressions. The life long persistence and regional activation may induce oncogenic activation of infected cells in some persons. Thus, EBV sometimes associates with lymphoid or epithelial cancers (Burkitt’s lymphoma, Hodgkin lymphoma, NK/T lymphoma, nasopharyngeal carcinoma, EBV-associated gastric cancers, and so on). EBV-specific immunity controls shift from lytic to latent infection as well as formation of EBV-associated cancers. In order to understand the complex interactions between EBV and host, this Special Issue will collect reviews or original research articles regarding recent advances in Epstein-Barr virus research, which is spanning from basic biology to potential clinical implications.
Prof. Hironori Yoshiyama
Prof. Teru Kanda
Guest Editors
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Keywords
- EBV
- Helicobacter pylori
- micro RNA
- infection-associated cancers
- immunodeficiency
- viral genome sequencing
- reverse genetics
- cancer biology
- cell biology
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