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Microorganisms
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Advances in Parvovirus Infection of Pets and Waterfowl
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Advances in Parvovirus Infection of Pets and Waterfowl

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Veterinary Microbiology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 7332

Special Issue Editor

Dr. Chuanfeng Li

E-Mail Website
Guest Editor
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China
Interests: canine parvovirus; feline parvovirus; duck parvovirus; goose parvovirus; genetic evolution

Special Issue Information

Dear Colleagues,

Parvovirus is a huge family of viruses with many members. Among them, some are capable of endangering human and animal health. Clinically, the members of the Parvovirus family have a broad range of hosts, from mammals to crustaceans, including dogs, cats, ducks, gooses, pigs, etc. Parvovirus infection in pets and Waterfowl frequently lead to a series of serious diseases, such as Canine viral gastroenteritis or myocarditis, Feline panleukopenia, Mink parvoviral enteritis, Gosling plague, Duck short beak and dwarfish syndrome, etc. Moreover, novel parvoviruses or variants often were detected in recent years. Therefore, continuous epidemiology investigation and research on the pathogenicity and novel vaccine development of the circulating viral strains are essential for disease prevention and control.

This Special Issue of Microorganisms aims to provide a scientific platform for scientists performing fundamental and applied research related to parvoviruses. This Special Issue of Microorganisms will include original research, short communications, and reviews on parvoviruses, which focus on the discovery and characterization of new parvoviruses, epidemiology, virus structure, genome composition, replication mechanism, genetic characterization, phylogeny, detection methods, parvovirus interactions with host cells, etc. In addition, some papers describing applied research in vaccines and antiviral biological products, including cytokines and antibodies, as well as diagnostic preparations, are also encouraged.

Dr. Chuanfeng Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • parvovirus
  • genetic evolution
  • pathogenicity
  • parvovirus–host interaction
  • epidemiology
  • genetic characterization
  • phylogeny
  • detection methods
  • vaccine
  • diagnostic preparations

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Published Papers (4 papers)

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Research

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17 pages, 3228 KiB  
Article
Identification of Host–Protein Interaction Network of Canine Parvovirus Capsid Protein VP2 in F81 Cells
by Hongzhuan Zhou, Huanhuan Zhang, Xia Su, Fuzhou Xu, Bing Xiao, Jin Zhang, Qi Qi, Lulu Lin, Kaidi Cui, Qinqin Li, Songping Li and Bing Yang
Microorganisms 2025, 13(1), 88; https://doi.org/10.3390/microorganisms13010088 - 5 Jan 2025
Viewed by 970
Abstract
Canine Parvovirus (CPV) is a highly contagious virus that causes severe hemorrhagic enteritis and myocarditis, posing a major threat to the life and health of dogs. The molecular mechanism by which VP2, the major capsid protein of CPV, infects host cells and utilizes [...] Read more.
Canine Parvovirus (CPV) is a highly contagious virus that causes severe hemorrhagic enteritis and myocarditis, posing a major threat to the life and health of dogs. The molecular mechanism by which VP2, the major capsid protein of CPV, infects host cells and utilizes host cell proteins for self-replication remains poorly understood. In this study, 140 host proteins specifically binding to CPV VP2 protein were identified by immunoprecipitation combined with liquid chromatography–mass spectrometry (LC-MS/MS). Subsequently, the protein Interaction Network (PPI), the annotation of gene ontology (GO) and the database of Kyoto Encyclopedia of Genes and Genomes (KEGG) were constructed for in-depth analysis. The results showed that CPV VP2 protein participated mainly in cell metabolism, cell biosynthesis, protein folding and various signal transduction processes. According to the results of proteomics analysis, we randomly selected seven proteins for co-immunoprecipitation verification, and the experimental results were consistent with the LC-MS/MS data. In addition, our study found that the expression level of the VP2-interacting protein FHL2 mediated CPV replication. Preliminary studies have shown that knockdown of FHL2 promotes CPV replication by decreasing the expression of interferon β (IFN-β) and interferon-stimulated genes (ISGs), while overexpression of FHL2 can inhibit the replication of CPV by up-regulating the expression of IFN-β and related ISGs. This study lays the foundation for elucidating the potential function of CPV VP2 protein in the process of viral infection and proliferation which provides a theoretical basis for the design of antiviral agents and vaccines. Full article
(This article belongs to the Special Issue Advances in Parvovirus Infection of Pets and Waterfowl)
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17 pages, 2733 KiB  
Article
The Structural, Biophysical, and Antigenic Characterization of the Goose Parvovirus Capsid
by Korosh Jabbari, Mario Mietzsch, Jane Hsi, Paul Chipman, Jianming Qiu and Robert McKenna
Microorganisms 2025, 13(1), 80; https://doi.org/10.3390/microorganisms13010080 - 3 Jan 2025
Viewed by 1335
Abstract
Goose parvovirus (GPV) is an etiological agent of Derzsy’s disease, afflicting geese and Muscovy ducks worldwide. Its high mortality rate among goslings and ducklings causes large losses to the waterfowl industry. Toward molecular and structural characterization, virus-like particles (VLPs) of GPV were produced, [...] Read more.
Goose parvovirus (GPV) is an etiological agent of Derzsy’s disease, afflicting geese and Muscovy ducks worldwide. Its high mortality rate among goslings and ducklings causes large losses to the waterfowl industry. Toward molecular and structural characterization, virus-like particles (VLPs) of GPV were produced, and the capsid structure was determined by cryogenic electron microscopy (cryo-EM) at a resolution of 2.4 Å. The capsid exhibited structural features conserved among parvoviruses, including surface two-fold depressions, three-fold protrusions, and five-fold channels. A structural comparison of the GPV viral protein (VP) structure with other adeno-associated viruses (AAVs), including human AAV2, AAV5, and quail AAV (QAAV), revealed unique conformations of several surface-accessible variable regions (VRs). Furthermore, the GPV capsid was found to be thermally stable at physiological pH, but less so under lower pH conditions. As a member of the genus Dependoparvovirus, GPV could also be bound by cross-reactive anti-AAV capsid antibodies that bind to the five-fold region of the viruses, as shown by native immuno-dot blot analysis. Finally, the GPV VP structure was compared to those of other bird dependoparvoviruses, which revealed that VR-III may be important for GPV and Muscovy duck parvovirus (MDPV) infection. Full article
(This article belongs to the Special Issue Advances in Parvovirus Infection of Pets and Waterfowl)
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11 pages, 4718 KiB  
Article
Genetic Diversity and Recombination Analysis of Canine Parvoviruses Prevalent in Central and Eastern China, from 2020 to 2023
by Shunshun Pan, Yuanzhuo Man, Xin Xu, Jun Ji, Shiyuan Zhang, Honghui Huang, Ying Li, Yingzuo Bi and Lunguang Yao
Microorganisms 2024, 12(11), 2173; https://doi.org/10.3390/microorganisms12112173 - 29 Oct 2024
Cited by 1 | Viewed by 1173
Abstract
Canine parvovirus type-2 (CPV-2), the primary causative agent of serious canine enteric diseases, is highly contagious and associated with high fatality rates worldwide. To comprehend the current emergence of CPV-2 in central and eastern China, 130 rectal swabs from domestic or stray dogs [...] Read more.
Canine parvovirus type-2 (CPV-2), the primary causative agent of serious canine enteric diseases, is highly contagious and associated with high fatality rates worldwide. To comprehend the current emergence of CPV-2 in central and eastern China, 130 rectal swabs from domestic or stray dogs with gastroenteritis symptoms were collected during 2020–2023. A total of 118 positive samples were detected via polymerase chain reaction, and further used to amplify and sequence the VP2 gene. Sequence analysis of the deduced amino acids of VP2 protein indicated that CPV-2c was the most prevalent variant (n = 106, 89.83%), followed by the novel CPV-2a (n = 10, 8.47%) and CPV-2b (n = 2, 1.69%) variants. The VP2 protein from the obtained and reference strains showed 86.95% (AH2103 and HB2108) to 99.94% identity. Based on the nine predicted recombination events, some prevalent CPV-2c strains were highly similar to previously isolated strains, indicating their complex evolution and recombination. The predicted analysis suggested that mutations in the antigen epitope (Val219Ile, Phe267Tyr, and Asn426Glu) and other mutations (Met87Leu, Ile101Thr, and Ser297Ala) affect the tertiary structure of the VP2 protein. This research will help us understand the recent evolution and mutation of Chinese CPV-2 and provide suggestions for updating the CPV-2 vaccine. Full article
(This article belongs to the Special Issue Advances in Parvovirus Infection of Pets and Waterfowl)
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Review

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16 pages, 2295 KiB  
Review
Overview of Recent Advances in Canine Parvovirus Research: Current Status and Future Perspectives
by Hongzhuan Zhou, Kaidi Cui, Xia Su, Huanhuan Zhang, Bing Xiao, Songping Li and Bing Yang
Microorganisms 2025, 13(1), 47; https://doi.org/10.3390/microorganisms13010047 - 30 Dec 2024
Cited by 3 | Viewed by 3325
Abstract
Canine parvovirus (CPV-2) was first identified in the late 1970s and has since become one of the most significant infectious agents affecting dogs. CPV-2 causes severe diseases such as hemorrhagic gastroenteritis and myocarditis, posing a major threat to canine health, particularly with a [...] Read more.
Canine parvovirus (CPV-2) was first identified in the late 1970s and has since become one of the most significant infectious agents affecting dogs. CPV-2 causes severe diseases such as hemorrhagic gastroenteritis and myocarditis, posing a major threat to canine health, particularly with a high mortality rate in puppies. It is globally recognized as a highly contagious and lethal pathogen. CPV is prone to rapid mutation, leading to the emergence of new variants. Despite widespread vaccination efforts, CPV remains one of the primary causes of acute gastroenteritis and death in young and juvenile dogs. Furthermore, the detection of CPV in swine populations has introduced additional challenges to its control. This review summarizes the current epidemiological status of CPV, highlighting recent advancements in diagnostic techniques and vaccine development. Additionally, it discusses the latest research on the pathogenesis of the virus and the development of antiviral agent research and proposes prevention and control suggestions for CPV under the One Health concept. In particular, there is a need to enhance surveillance of viral dynamics, accelerate the development of novel vaccines, and deepen the exploration of the underlying pathogenic mechanisms. This review aims to provide a scientific foundation for effective control of CPV and to guide future research directions. Full article
(This article belongs to the Special Issue Advances in Parvovirus Infection of Pets and Waterfowl)
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