Prioritizing Diseases for Public Health in Emergency Contexts: A WHO Initiative

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Public Health Microbiology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1952

Special Issue Editor


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Guest Editor
1. Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplantation, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy
2. Department of Laboratory Medicine and Anatomical Pathology, University Hospital of Modena—Polyclinic, Modena, Italy
Interests: pathology oncology gynecology; human papilloma virus (HPV); epstein–barr virus (EBV); human herpes virus 8 (HHV8); coronavirus disease 2019 (COVID-19); severe acute respiratory syndrome (SARS); middle east respiratory syndrome (MERS); nipah virus ebola virus
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Special Issue Information

Dear Colleagues,

Globally, the number of potentially pathogenic microorganisms is very large, while resources for disease Research and Development (R&D) are limited. To ensure that efforts are targeted and productive, the World Health Organization (WHO) has compiled a list of priority diseases and pathogens for R&D in emergency contexts. These diseases represent the greatest risk to public health due to their pandemic-epidemic potential and/or the absence or insufficiency of countermeasures. This systematic approach explicitly aims to enable early and cross-cutting R&D preparation, also relevant for an unknown «Disease X». It represents the realization that a major international threat could be caused by a pathogen currently unknown as a cause of human disease.  At present, the priority infectious diseases are: (I) Coronavirus Disease 2019 (COVID-19); (II) Severe Acute Respiratory Syndrome (SARS); (III) Middle East Respiratory Syndrome (MERS); (IV) Nipah & Henipaviral Diseases; (V) Ebola Hemorrhagic Fever (EHF); (VI) Marburg Hemorrhagic Fever (MHF); (VII) Lassa Hemorrhagic Fever (LHF); (VIII) Crimean-Congo Hemorrhagic Fever (CCHF); (IX) Rift Valley Fever (RVF); (X) Zika Fever; (XI) Monkeypox; (XII) Plague. The scope of this Special Issue is therefore R&D in all these diseases to ensure progress in the interest of mankind and future generations, who in turn must absolutely respect the animals and nature around us following the One Health approach to avoid the outbreak of the aforementioned «Disease X».

Dr. Luca Roncati
Guest Editor

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Keywords

  • coronavirus disease 2019 (COVID-19)
  • severe acute respiratory syndrome (SARS)
  • middle east respiratory syndrome (MERS)
  • nipah virus
  • ebola hemorrhagic fever (EHF)
  • marburg hemorrhagic fever (MHF)
  • lassa hemorrhagic fever (LHF)
  • crimean–congo hemorrhagic fever (CCHF)
  • rift valley fever (RVF)
  • zika fever
  • monkeypox
  • plague

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Published Papers (2 papers)

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13 pages, 2087 KiB  
Article
Trends in SARS-CoV-2 Cycle Threshold Values in Bosnia and Herzegovina—A Retrospective Study
by Almedina Moro, Adis Softić, Maja Travar, Šejla Goletić, Jasmin Omeragić, Amira Koro-Spahić, Naida Kapo, Visnja Mrdjen, Ilma Terzić, Maja Ostojic, Goran Cerkez and Teufik Goletic
Microorganisms 2024, 12(8), 1585; https://doi.org/10.3390/microorganisms12081585 - 4 Aug 2024
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Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which led to the COVID-19 pandemic, has significantly impacted global public health. The proper diagnosis of SARS-CoV-2 infection is essential for the effective control and management of the disease. This study investigated the [...] Read more.
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which led to the COVID-19 pandemic, has significantly impacted global public health. The proper diagnosis of SARS-CoV-2 infection is essential for the effective control and management of the disease. This study investigated the SARS-CoV-2 infection using RT-qPCR tests from laboratories in Bosnia and Herzegovina. We performed a retrospective study of demographic data and Ct values from 170,828 RT-qPCR tests from April 2020 to April 2023, representing 9.3% of total national testing. Samples were collected from 83,413 individuals across different age groups. Of all tests, 33.4% were positive for SARS-CoV-2, with Ct values and positivity rates varying across demographics and epidemic waves. The distribution was skewed towards older age groups, although lower positivity rates were observed in younger age groups. Ct values, indicative of viral load, ranged from 12.5 to 38. Lower Ct values correlated with higher positive case numbers, while higher Ct values signaled outbreak resolution. Additionally, Ct values decreased during epidemic waves but increased with the dominance of certain variants. Ct value-distribution has changed over time, particularly after the introduction of SARS-CoV-2 variants of interest/concern. Established Ct value trends might, therefore, be used as an early indicator and additional tool for informed decisions by public health authorities in SARS-CoV-2 and future prospective pandemics. Moreover, they should not be overlooked in future epidemiological events. Full article
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39 pages, 51849 KiB  
Review
Towards a Comprehensive Definition of Pandemics and Strategies for Prevention: A Historical Review and Future Perspectives
by Ricardo Augusto Dias
Microorganisms 2024, 12(9), 1802; https://doi.org/10.3390/microorganisms12091802 - 30 Aug 2024
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Abstract
The lack of a universally accepted definition of a pandemic hinders a comprehensive understanding of and effective response to these global health crises. Current definitions often lack quantitative criteria, rendering them vague and limiting their utility. Here, we propose a refined definition that [...] Read more.
The lack of a universally accepted definition of a pandemic hinders a comprehensive understanding of and effective response to these global health crises. Current definitions often lack quantitative criteria, rendering them vague and limiting their utility. Here, we propose a refined definition that considers the likelihood of susceptible individuals contracting an infectious disease that culminates in widespread global transmission, increased morbidity and mortality, and profound societal, economic, and political consequences. Applying this definition retrospectively, we identify 22 pandemics that occurred between 165 and 2024 AD and were caused by a variety of diseases, including smallpox (Antonine and American), plague (Justinian, Black Death, and Third Plague), cholera (seven pandemics), influenza (two Russian, Spanish, Asian, Hong Kong, and swine), AIDS, and coronaviruses (SARS, MERS, and COVID-19). This work presents a comprehensive analysis of past pandemics caused by both emerging and re-emerging pathogens, along with their epidemiological characteristics, societal impact, and evolution of public health responses. We also highlight the need for proactive measures to reduce the risk of future pandemics. These strategies include prioritizing surveillance of emerging zoonotic pathogens, conserving biodiversity to counter wildlife trafficking, and minimizing the potential for zoonotic spillover events. In addition, interventions such as promoting alternative protein sources, enforcing the closure of live animal markets in biodiversity-rich regions, and fostering global collaboration among diverse stakeholders are critical to preventing future pandemics. Crucially, improving wildlife surveillance systems will require the concerted efforts of local, national and international entities, including laboratories, field researchers, wildlife conservationists, government agencies and other stakeholders. By fostering collaborative networks and establishing robust biorepositories, we can strengthen our collective capacity to detect, monitor, and mitigate the emergence and transmission of zoonotic pathogens. Full article
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