Research on Leishmania and Leishmaniasis: Second Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 521

Special Issue Editors


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Guest Editor
Pathology Laboratory of Infectious Diseases (LIM50), Pathology Department, Medical School, São Paulo University, São Paulo 1246-903, São Paulo State, Brazil
Interests: immunopathology of leishmaniasis; infectious disease; immunopathology; immunity; diagnosis; treatment; leishmaniasis
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Guest Editor
Institute for Advanced Studies of Ocean, São Paulo State University (UNESP), São Vicente 11350-011, Brazil
Interests: neglected tropical diseases; parasite; bacteria; virus; fungus; oral and local treatment; formulations; dermatological cream; liposome; nanoparticles; immunity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our 2023 Special Issue, "Research on Leishmania and Leishmaniasis".

Leishmania are flagellated kinetoplast parasites that infect phagocytic cells of the vertebrate host and the alimentary tract of sandfly vectors. Parasites that belong to the genus Leishmania cause varied devasting and often fatal diseases in humans and domestic animals worldwide depending on the parasite species and the host’s genetic and immunological background. The genus Leishmania comprises a wide range of species, and these different species have different tissue tropisms pathogenic to humans, resulting in different clinical forms of  human leishmaniasis such as visceral, cutaneous, anergic diffuse cutaneous, mucocutaneous, or atypical cutaneous disease. The need for new therapeutic strategies is urgent because no vaccine is available, and treatment options are limited due to a lack of specificity, collateral effects, and the emergence of drug resistance.

In this Special Issue of Microorganisms, we invite you to send your contributions concerning any aspects related to Leishmania and leishmaniasis. We hope that this knowledge will improve the treatment, follow-up, and cure control of patients; minimize the potential damage that this protozoosis can cause to infected individuals; and help establish public polices for the control of this neglected tropical disease.

Dr. Mãrcia Dalastra Laurenti
Dr. Luiz Felipe Domingues Passero
Guest Editors

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Keywords

  • leishmania
  • leishmaniasis
  • drug treatment
  • vaccine
  • host-parasite interaction

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Published Papers (1 paper)

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10 pages, 1135 KiB  
Case Report
Visceral Leishmaniasis in a 25-Year-Old Female Kidney Transplant Recipient from a Non-Endemic Region: A Case Report from Romania
by Alin Gabriel Mihu, Mariana Patiu, Delia Monica Dima, Daniela Adriana Oatis, Cristina Mihaela Cismaru, Rodica Lighezan and Tudor Rares Olariu
Microorganisms 2025, 13(2), 403; https://doi.org/10.3390/microorganisms13020403 - 12 Feb 2025
Viewed by 451
Abstract
Visceral leishmaniasis is a rare parasitic infection in non-endemic regions such as Romania. We report the case of a 25-year-old female kidney transplant recipient from Cluj County, Romania, who developed persistent bicytopenia with anemia and thrombocytopenia. Despite no history of travel outside Cluj [...] Read more.
Visceral leishmaniasis is a rare parasitic infection in non-endemic regions such as Romania. We report the case of a 25-year-old female kidney transplant recipient from Cluj County, Romania, who developed persistent bicytopenia with anemia and thrombocytopenia. Despite no history of travel outside Cluj County and being the only organ recipient from the same donor to experience signs and symptoms, she was diagnosed with visceral leishmaniasis. The second bone marrow aspirate performed revealed Leishmania amastigotes. She was quickly sent to Victor Babes Infectious Disease Hospital in Bucharest for additional tests and treatment. The kidney function of the patient was maintained. This case highlights the importance of considering leishmaniasis in immunosuppressed patients presenting with unexplained cytopenia, even in non-endemic regions. This is the first documented case of visceral leishmaniasis in a kidney transplant recipient in Romania. The present report could serve as a foundation for future educational programs targeted toward informing both healthcare providers and patients about the risks, diagnosis, and management of leishmaniasis in immunosuppressed individuals in non-endemic regions. Full article
(This article belongs to the Special Issue Research on Leishmania and Leishmaniasis: Second Edition)
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