Effects of Probiotics and Their Derived Bioactive Compounds on Host Health

Dear Colleagues,

The host intestinal is a bustling ecosystem inhabited by trillions of microbes, collectively known as the gut microbiota. This intricate community is now recognized as a key player in modulating host health and disease susceptibility. Probiotics, live microorganisms that confer a health benefit on the host when administered in adequate amounts, have been widely studied for their capacity to modulate the gut microbiota and exert immunomodulatory effects.

This Special Issue aims to dissect the multifaceted roles of probiotics and their derived bioactive compounds, such as bacteriocins, short-chain fatty acids (SCFAs), bile acids, and extracellular vesicles, in influencing the host metabolism and immune system. It will cover a range of topics, including, but not limited to, the following:

Immunomodulation by Probiotics: The mechanisms by which probiotics interact with the host's immune cells, leading to the modulation of immune responses and the enhancement of the gut barrier’s function.

Bioactive Compounds from Probiotics: A focus on the production of bioactive molecules like SCFAs, bacteriocins, bile acids, and extracellular vesicles, their impact on gut homeostasis, and their potential as therapeutic agents.

Application Potential: The translational potential of probiotics in managing various diseases, including gastrointestinal disorders, metabolic syndromes, and immune-mediated conditions.

Safety and Tolerability: Addressing the safety profile of probiotics, including potential risks and the need for strain-specific evaluation to ensure beneficial effects without adverse outcomes.

Future Directions: Exploring the frontiers of probiotic research, such as postbiotic effects, personalized probiotic therapies, and the integration of omics technologies in probiotic studies.

Dr. Shiyu Tao
Guest Editor

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• probiotic
• bioactive compounds
• short-chain fatty acids (SCFAs)
• bacteriocins
• bile acids
• extracellular vesicles
• host metabolism
• immune