Probiotics and Synbiotics—Options to Manage Infections with Multi-Drug Resistant Bacteria?
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".
Deadline for manuscript submissions: closed (20 November 2021) | Viewed by 2596
Special Issue Editor
Interests: probiotics; gut microbiota; antimicrobial activity; pathogen overgrowth; Clostridium infections
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antibiotic resistance has become a major concern worldwide. Bacteria with a broad range of resistance against antibiotics are spreading at an alarming rate. Hospitals, and in particular intensive care units, are proliferation zones for multi-drug-resistant bacteria. The first bacterial strains have emerged that are resistant against all available antibiotics. The steady trend of increasing resistance coupled with the lack of new antibiotic developments targeting resistant bacteria is forcing clinicians to apply more aggressive antibiotic dosing regimens, such as prolonged administration and combinations of different antibiotics. However, this increase in antibiotic utilization may not be the solution, and might instead add to the problem. While good antibiotic stewardship is one important pillar in limiting antibiotic resistance development, new non-antibiotic strategies have to be considered for the management of infections with multi-drug-resistant bacterial pathogens. Colonization resistance provided by a balanced and diverse gut microbiota is a well-known mechanism to keep the spread of bacterial pathogens under control in the human body. The administration of pro- or synbiotics is a promising strategy to support this natural mechanism. Prophylactic administration of probiotic bacteria as well as administration in combination with antibiotics have to be considered. While there are first promising data showing the value of pro- and synbiotics in the management of infections with multi-drug-resistant infection, more research is needed to establish a better understanding of the potential role of probiotic microorganisms in this challenging task of healthcare.
Dr. Jacek Piatek
Guest Editor
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Keywords
- gut microbiota
- probiotics
- synbiotics
- gut colonization resistance
- multi-drug resistance
- pathogen inhibition
- nosocomial infections
- post-antibiotic era
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