SARS-CoV-2: Infection Models and Vaccines

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Virology".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 3642

Special Issue Editor


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Guest Editor
Department Virology, CHU grenoble Alpes, Grenoble, France
Interests: virology; NGS; flow cytometry; bioinformatic analyses; cultures

Special Issue Information

Dear Colleagues,

The emergence of SARS-CoV-2 presents a considerable challenge for the scientific community and public health. However, the development of vaccines, monoclonal antibodies and antivirals has been spectacular. This accumulation of knowledge has led to a better understanding of COVID-19 and the progression of the disease in patients. Nevertheless, some factors for poor prognosis are not well-understood, for example those faced by the diabetic population. Moreover, mechanisms of escape selection, notably through the emergence of variants, are not well-characterized either. We are pleased to invite you to submit research articles regarding vaccine studies or infection models of SARS-CoV-2. Both in vitro and in vivo models are a complementary approach to describe and explore SARS-CoV-2, and these fundamental experiments could help to elucidate some of these questions.

In this Special Issue, original research articles and reviews are welcome, as the current pandemic requires continuous innovation.

I look forward to receiving your contributions.

Dr. Julien Andréani
Guest Editor

Manuscript Submission Information

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Keywords

  • SARS-CoV-2
  • COVID-19
  • in vitro models
  • in vivo models
  • vaccines
  • antivirals
  • monoclonal antibodies

Published Papers (1 paper)

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Research

13 pages, 2397 KiB  
Article
Age, Sex and BMI Relations with Anti-SARS-CoV-2-Spike IgG Antibodies after BNT162b2 COVID-19 Vaccine in Health Care Workers in Northern Greece
by Paraskevi Papaioannidou, Kalypso Skoumpa, Christos Bostanitis, Maria Michailidou, Theodouli Stergiopoulou, Ioannis Bostanitis and Maria Tsalidou
Microorganisms 2023, 11(5), 1279; https://doi.org/10.3390/microorganisms11051279 - 13 May 2023
Cited by 3 | Viewed by 1861
Abstract
The aim of this work was to study age, sex, and BMI (Body Mass Index)-related differences in the development of anti-SARS-CoV-2-Spike IgG antibodies, after vaccination with the BNT162b2 COVID-19 vaccine, in health care workers of a General Hospital in a city in Northern [...] Read more.
The aim of this work was to study age, sex, and BMI (Body Mass Index)-related differences in the development of anti-SARS-CoV-2-Spike IgG antibodies, after vaccination with the BNT162b2 COVID-19 vaccine, in health care workers of a General Hospital in a city in Northern Greece. Blood sampling was drawn two to four weeks following the second dose of the vaccine, and six months after the first blood sample collection. Measurement of serum IgG antibodies against the spike domain of SARS-CoV-2 was performed using the SARS-CoV-2 IgG II Quant assay. All participants had sufficient serum IgG titers in the first measurement. Women developed higher IgG titers than men. The IgG titers were inversely related to age in both sexes; there was also a small, insignificant tendency to be inversely related to BMI. Six months after the first measurement, the IgG titers decreased dramatically to values less than 5% of the initial. This decrease was observed in both men and women and was inversely related to age. Multivariate regression analysis showed that age and sex explained with statistical significance 9% of the variance in SARS-CoV-2 IgG titers in our study population; the role of BMI was limited and insignificant. Full article
(This article belongs to the Special Issue SARS-CoV-2: Infection Models and Vaccines)
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