Bacterial Protein Toxins I

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 6468

Special Issue Editor


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Guest Editor
Department of Food Science and Engineering, ELTEC College of Engineering, Ewha Womans University, Seoul 03760, Korea
Interests: bacterial protein toxins; bacterial pathogenesis; host-microbe interaction; microbe-microbe interaction; Vibrio vulnificus

Special Issue Information

Dear Colleagues,

In the ‘post-antibiotics era’, bacterial infection is still one of the biggest concerns that threaten human beings worldwide. Meanwhile, certain pathogenic bacteria significantly affect yields of important livestock, agriculture and aquaculture, which are crucial to meeting the demand of the world’s growing population. Among various virulence determinants of pathogenic bacteria, protein toxins directly adjust the host–pathogen interactions by targeting, disrupting, or modifying the key components of host cells, such as proteins, lipids, glycan, or signaling molecules. Therefore, understanding and exploring the molecular mechanisms of bacterial protein toxins not only offers a new venue for potential therapeutic targets/strategies against bacterial infections, but also provide novel insights into host cells’ defense tactics and molecular physiology. If the activity, efficacy, or target tropism is appropriately controlled, the engineered bacterial protein toxins can also be useful in the fields of basic research and medicine.

In this context, I cordially encourage you to submit original research papers, short communications, or reviews to the current Special Issue, ‘Bacterial protein toxins’. The goal of this Special Issue is to broaden the knowledge of the types, targets and potential mechanisms of bacterial protein toxins, and to advance its biotechnological usefulness based on the structure–function properties. Interesting subjects include, but are not limited to toxin structure and molecular mechanisms, toxin secretion and translocation, molecular pathogenesis, pore-forming toxins, AB-type toxins, RTX toxins, and effector domains.

Dr. Byoung Sik Kim
Guest Editor

Manuscript Submission Information

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Keywords

  • Bacterial protein toxin 
  • Toxin structure and molecular mechanisms 
  • Toxin secretion and traslocation 
  • Molecular pathogenesis
  • Pore-forming toxins
  • AB-type toxins
  • RTX toxins
  • Effector proteins

Published Papers (1 paper)

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Review

28 pages, 2735 KiB  
Review
Serine Protease Autotransporters of the Enterobacteriaceae (SPATEs): Out and About and Chopping It Up
by Pravil Pokharel, Hajer Habouria, Hicham Bessaiah and Charles M. Dozois
Microorganisms 2019, 7(12), 594; https://doi.org/10.3390/microorganisms7120594 - 21 Nov 2019
Cited by 24 | Viewed by 6045
Abstract
Autotransporters are secreted proteins with multiple functions produced by a variety of Gram-negative bacteria. In Enterobacteriaceae, a subgroup of these autotransporters are the SPATEs (serine protease autotransporters of Enterobacteriaceae). SPATEs play a crucial role in survival and virulence of pathogens such [...] Read more.
Autotransporters are secreted proteins with multiple functions produced by a variety of Gram-negative bacteria. In Enterobacteriaceae, a subgroup of these autotransporters are the SPATEs (serine protease autotransporters of Enterobacteriaceae). SPATEs play a crucial role in survival and virulence of pathogens such as Escherichia coli and Shigella spp. and contribute to intestinal and extra-intestinal infections. These high molecular weight proteases are transported to the external milieu by the type Va secretion system and function as proteases with diverse substrate specificities and biological functions including adherence and cytotoxicity. Herein, we provide an overview of SPATEs and discuss recent findings on the biological roles of these secreted proteins, including proteolysis of substrates, adherence to cells, modulation of the immune response, and virulence in host models. In closing, we highlight recent insights into the regulation of expression of SPATEs that could be exploited to understand fundamental SPATE biology. Full article
(This article belongs to the Special Issue Bacterial Protein Toxins I)
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