The Mechanism of Cross-Resistance between Heavy Metals and Antibiotics

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 3325

Special Issue Editors


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Guest Editor
Microbiology Unit, Department of Botany and Plant Biology, Sciences III, University of Geneva, 1211 Geneva, Switzerland
Interests: metal homeostasis; metal resistance; Pseudomonas aeruginosa; antimicrobial resistance; new antimicrobial molecules

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Guest Editor
Université de Genève Faculté de Médecine, Geneva, Switzerland
Interests: Pseudomonas aeruginosa; RNA-binding proteins; small RNAs; RNA metabolism; microbial biofilm formation; cyclic di-nucleotide signaling; microbial regulatory networks

Special Issue Information

Dear Colleagues,

The problem of antibiotic resistance is one of the leading global health concerns to date. The increasing incidence of resistant strains results in antibiotics that become ineffective. This, along with the lack of new antimicrobial molecules, determines that many once-treatable infections are becoming fatal. The overuse and misuse of antibiotics are well-known to select antibiotic-resistant strains of bacteria, but other factors, often overlooked, also act as major co-selective pressure for antibiotic resistance. This is particularly the case of heavy metals.

The purpose of this Special Issue “The Mechanism of Cross-Resistance between Heavy Metals and Antibiotics” is to highlight the latest research on the subject and to create a network of partners in this field. The current research aim is no longer to simply observe the phenomenon of cross-resistance, but rather to understand the underlying mechanisms of this co-selection. These mechanisms might have emerged from the thriving of bacteria in environmental reservoirs (soil or water) contaminated with metals, or could also result from their adaptation to the immune responses involving metals during a human or animal infection. The scope of the research is thus fully integrated with the One Health concept.

We hereby invite you to submit your research papers or reviews related to this emerging key field of research, and to disseminate the information about this call to your colleagues.

Dr. Karl Perron
Dr. Martina Valentini
Guest Editors

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Published Papers (1 paper)

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Research

12 pages, 1138 KiB  
Article
Whole Genome Sequencing of Methicillin-Resistant Staphylococcus epidermidis Clinical Isolates Reveals Variable Composite SCCmec ACME among Different STs in a Tertiary Care Hospital in Oman
by Zaaima Al-Jabri, Zahra AL-Shabibi, Atika AL-Bimani, Amal AL-Hinai, Ammar AL-Shabibi and Meher Rizvi
Microorganisms 2021, 9(9), 1824; https://doi.org/10.3390/microorganisms9091824 - 27 Aug 2021
Cited by 3 | Viewed by 2760
Abstract
Staphylococcus epidermidis has been recently recognized as an emerging nosocomial pathogen. There are concerns over the increasing virulence potential of this commensal due to the capabilities of transferring mobile genetic elements to Staphylococcus aureus through staphylococcal chromosomal cassette (SCCmec) and the [...] Read more.
Staphylococcus epidermidis has been recently recognized as an emerging nosocomial pathogen. There are concerns over the increasing virulence potential of this commensal due to the capabilities of transferring mobile genetic elements to Staphylococcus aureus through staphylococcal chromosomal cassette (SCCmec) and the closely related arginine catabolic mobile element (ACME) and the copper and mercury resistance island (COMER). The potential pathogenicity of S. epidermidis, particularly from blood stream infections, has been poorly investigated. In this study, 24 S. epidermidis isolated from blood stream infections from Oman were investigated using whole genome sequence analysis. Core genome phylogenetic trees revealed one third of the isolates belong to the multidrug resistance ST-2. Genomic analysis unraveled a common occurrence of SCCmec type IV and ACME element predominantly type I arranged in a composite island. The genetic composition of ACME was highly variable among isolates of same or different STs. The COMER-like island was absent in all of our isolates. Reduced copper susceptibility was observed among isolates of ST-2 and ACME type I, followed by ACME type V. In conclusion, in this work, we identify a prevalent occurrence of highly variable ACME elements in different hospital STs of S. epidermidis in Oman, thus strongly suggesting the hypothesis that ACME types evolved from closely related STs. Full article
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