State-of-the-Art Gut Microbiota Research in France

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 2609

Special Issue Editor


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Guest Editor
Institute of Digestive Health Research, IRSD, INSERM U1220, Toulouse, France
Interests: host–microbiota interactions; mucosal biofilms; infectious and inflammatory gut disorders; microbiota ageing; intestinal epithelium
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Special Issue Information

Dear Colleagues,

This Special Issue of Microorganisms will give an overview of current gut microbiota research being performed in France, both in fundamental (CNRS) and applied host institutions (INSERM, CEA, INRAe), and with a particular focus on the impact of this research for human health perspectives. Current studies on how microbes influence host physiology and pathologies mostly rely on the taxonomic profiling of the gut microbiota from mouth to anus, communities living close to the mucosa and in the lumen, and in different pathological situations. However, there are still important gaps in our understanding of the causal relationship between alterations in the microbiota (i.e., dysbiosis) and disease initiation/progression, hence studies or reviews tackling this question will be welcomed in this Special Issue. Moreover, studies aiming at understanding with an ecological perspective how microbial communities interact with each other and their host environment represent an exciting research direction for the future, and will also be invited. In this Special Issue entitled “State-of-the-Art Gut Microbiota Research in France” we invite colleagues to contribute original research articles or reviews related to their multidisciplinary research, on topics including, but not limited to, the following:

  • Biologically relevant host–microbiota models, from in vitro to in vivo and ex vivo;
  • Structure and function of the microbiota;
  • Microbial community genetics, transcriptomics, proteomics and metabolomics;
  • Microbe–microbe interaction within host-associated microbial communities;
  • Metabolic interaction with the host;
  • Inflammatory diseases;
  • Interaction with the immune system;
  • Microbial biodegradation of nutrients and xenobiotics: role in drug response;
  • Microbial ecology;
  • Microbial biofilms interacting with host mucosa;
  • Microbial biogeography;
  • Microbial functions in the different habitats within the gut;
  • Metabolic flux analysis;
  • Analysis of functionalities by stable isotope probing (DNA, RNA, and protein);
  • Model systems for studying microbiome biology;
  • Novel technologies for the analysis of structure and function of the microbiota.

Dr. Jean-Paul Motta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

22 pages, 1606 KiB  
Review
Super Shedding in Enteric Pathogens: A Review
by Florent Kempf, Roberto La Ragione, Barbara Chirullo, Catherine Schouler and Philippe Velge
Microorganisms 2022, 10(11), 2101; https://doi.org/10.3390/microorganisms10112101 - 22 Oct 2022
Cited by 5 | Viewed by 2163
Abstract
Super shedding occurs when a small number of individuals from a given host population shed high levels of a pathogen. Beyond this general definition, various interpretations of the shedding patterns have been proposed to identify super shedders, leading to the description of the [...] Read more.
Super shedding occurs when a small number of individuals from a given host population shed high levels of a pathogen. Beyond this general definition, various interpretations of the shedding patterns have been proposed to identify super shedders, leading to the description of the super shedding phenomenon in a wide range of pathogens, in particular enteric pathogens, which are of considerable interest. Several underlying mechanisms may explain this observation, including factors related to the environment, the gut microbiota, the pathogen itself (i.e., genetic polymorphism), and the host (including immune factors). Moreover, data suggest that the interplay of these parameters, in particular at the host–pathogen–gut microbiota interface, is of crucial importance for the determination of the super shedding phenotype in enteric pathogens. As a phenomenon playing an important role in the epidemics of enteric diseases, the evidence of super shedding has highlighted the need to develop various control strategies. Full article
(This article belongs to the Special Issue State-of-the-Art Gut Microbiota Research in France)
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