Old and New Challenges in Mycobacterium Infection Treatment

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 8748

Special Issue Editors


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Guest Editor
Department of Oncology and Haemato-oncology – University of Milan, Milan, Italy; Microbiology and Virology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
Interests: antimicrobial resistance; virology; molecular epidemiology; respiratory infections

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Guest Editor
Department of Medical-Surgical Pathophysiology and Transplantation– University of Milan, Milan, Italy
Interests: non-tuberculous mycobacteria; pulmonary diseases; bronchiectasis; cystic fibrosis

Special Issue Information

Dear Colleagues,

The mycobacteria genus includes the greatest serial killers in the history of humankind, a lineage of skilled and devious pathogens, able to survive, multiply, and spread in an incredible variety of environmental niches, including humans.

Mycobacteria are extremely diverse organisms, able to act as species-specific pathogens responsible for major global health threats, or environmental saprophytes linked to a variety of largely neglected opportunistic clinical manifestations when the bacterial and human habitats overlap.

Our attempts toward their global eradication have, to date, been doomed to fail. Infections caused by mycobacteria are typically difficult to control, difficult to diagnose, and difficult to treat. The intrinsic resistance of these bacteria to many common antibiotics combines with an excellent ability to develop drug resistance following chromosome mutations, resulting in the generation of multidrug-resistant and pandrug-resistant variants, whose increasing global circulation is observed with growing concern.

This Special Issue aims to disseminate current research and knowledge on the most relevant microbiological, epidemiological, and clinical aspects related to the control of infection caused by tuberculosis-causing mycobacteria or non-tuberculous mycobacteria, with a particular focus on the generation and spread of drug resistance.

Dr. Valeria Cento
Prof. Stefano Aliberti
Guest Editors

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Keywords

  • tuberculosis
  • non-tuberculous mycobacteria
  • drug resistance
  • mycobacterial diagnosis
  • pulmonary diseases

Published Papers (2 papers)

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Review

11 pages, 563 KiB  
Review
T-Cell Exhaustion in Mycobacterium tuberculosis and Nontuberculous Mycobacteria Infection: Pathophysiology and Therapeutic Perspectives
by Andrea Lombardi, Simone Villa, Valeria Castelli, Alessandra Bandera and Andrea Gori
Microorganisms 2021, 9(12), 2460; https://doi.org/10.3390/microorganisms9122460 - 28 Nov 2021
Cited by 27 | Viewed by 2997
Abstract
Immune exhaustion is a condition associated with chronic infections and cancers, characterized by the inability of antigen-specific T cells to eliminate the cognate antigen. Exhausted T cells display a peculiar phenotypic profile and exclusive functional characteristics. Immune exhaustion has been described in patients [...] Read more.
Immune exhaustion is a condition associated with chronic infections and cancers, characterized by the inability of antigen-specific T cells to eliminate the cognate antigen. Exhausted T cells display a peculiar phenotypic profile and exclusive functional characteristics. Immune exhaustion has been described in patients with Mycobacterium tuberculosis infection, and cases of tuberculosis reactivation have been reported in those treated with immune checkpoint inhibitors, drugs able to re-establish T-cells’ function. Exhausted T CD8+ cells’ profile has also been described in patients with infection due to nontuberculous mycobacteria. In this review, we initially provide an overview of the mechanisms leading to immune exhaustion in patients infected by Mycobacterium tuberculosis and nontuberculous mycobacteria. We then dissect the therapeutic perspectives related to immune checkpoint blockade in patients with these infections. Full article
(This article belongs to the Special Issue Old and New Challenges in Mycobacterium Infection Treatment)
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20 pages, 3583 KiB  
Review
Phage Therapy for Mycobacterium Abscessus and Strategies to Improve Outcomes
by Abdolrazagh Hashemi Shahraki and Mehdi Mirsaeidi
Microorganisms 2021, 9(3), 596; https://doi.org/10.3390/microorganisms9030596 - 14 Mar 2021
Cited by 13 | Viewed by 5243
Abstract
Members of Mycobacterium abscessus complex are known for causing severe, chronic infections. Members of M. abscessus are a new “antibiotic nightmare” as one of the most resistant organisms to chemotherapeutic agents. Treatment of these infections is challenging due to the either intrinsic or [...] Read more.
Members of Mycobacterium abscessus complex are known for causing severe, chronic infections. Members of M. abscessus are a new “antibiotic nightmare” as one of the most resistant organisms to chemotherapeutic agents. Treatment of these infections is challenging due to the either intrinsic or acquired resistance of the M. abscessus complex to the available antibiotics. Recently, successful phage therapy with a cocktail of three phages (one natural lytic phage and two engineered phages) every 12 h for at least 32 weeks has been reported against a severe case of the disseminated M. abscessus subsp. massiliense infection, which underlines the high value of phages against drug-resistant superbugs. This report also highlighted the limitations of phage therapy, such as the absence of lytic phages with a broad host-range against all strains and subspecies of the M. abscessus complex and also the risk of phage resistant bacteria over treatment. Cutting-edge genomic technologies have facilitated the development of engineered phages for therapeutic purposes by introducing new desirable properties, changing host-range and arming the phages with additional killing genes. Here, we review the available literature and suggest new potential solutions based on the progress in phage engineering that can help to overcome the present limitations of M. abscessus treatment. Full article
(This article belongs to the Special Issue Old and New Challenges in Mycobacterium Infection Treatment)
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