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Microorganisms
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Natural Compounds Targeting Quorum Sensing in Microorganisms
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Natural Compounds Targeting Quorum Sensing in Microorganisms

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 20271

Special Issue Editors

Dr. Alexey Vasilchenko

E-Mail Website
Guest Editor
Institute of Biological and Agricultural Biology (X-Bio), Tyumen State University, 625003 Tyumen, Russia
Interests: novel antibiotics; microbial quorum sensing; plant-protection; antimicrobial resistance; subinhibitory effects
Special Issues, Collections and Topics in MDPI journals
Dr. Dmitry G. Deryabin

E-Mail Website
Co-Guest Editor
Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of Sciences, Orenburg 460000, Russia
Interests: quorum sensing inhibitors; antimicrobials; antimicrobial resistance
Dr. Larisa Yu. Nesterova

E-Mail Website
Co-Guest Editor
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Goleva street 13, 614081 Perm, Russia
Interests: microorganisms adaptation; polyamines; quorum sensing; antibiotics; biofilms

Special Issue Information

Dear Collegues,

Quorum sensing (QS) is a cell-cell communication system that is ubiquitously used in microbial communities to monitor their population density and adapt to the external environment. 

Over the past two decades, a significant amount of data on the molecular organization of QS systems has been accumulated, and many phenomena from microbial life that regulated by the quorum sensing have been described.

Several types of quorum sensing systems and numerous QS-messengers, which are different in structure and origin are known. A significant number of research projects have focused on quorum sensing inhibitors as an alternative to conventional antibiotics for fighting infections since the virulence factors (toxins, proteases, and immune-evasion factors) are in many zoopathogenic and phytopathogenic bacteria mediated by QS-molecules. However, quorum sensing defines not only interspecies competitions, but is also involved in microbial cooperation.

The aim of this Special Issue is to present a current and compelling collection of research articles that expand the knowledge about various aspects of microbial behavior regulated with quorum sensing.  

The proposed Research Topic editors will welcome authors to publish state-of-the-art research focusing on the following themes: 

  • Quorum sensing inhibitors as anti-infective agents. 
  • Novel quorum sensing messengers and their role in microbial physiology.
  • Antibiotics as quorum sensing modulators.
  • Interspecies relationships related to quorum sensing modulation.

Dr. Alexey S. Vasilchenko
Dr. Dmitry G. Deryabin
Dr. Larisa Yu. Nesterova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (5 papers)

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Research

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13 pages, 1323 KiB  
Article
Plant-Derived Quorum Sensing Inhibitors (Quercetin, Vanillin and Umbelliferon) Modulate Cecal Microbiome, Reduces Inflammation and Affect Production Efficiency in Broiler Chickens
by Dmitry G. Deryabin, Dianna B. Kosyan, Ksenia S. Inchagova and Galimzhan K. Duskaev
Microorganisms 2023, 11(5), 1326; https://doi.org/10.3390/microorganisms11051326 - 18 May 2023
Cited by 2 | Viewed by 1730
Abstract
Quorum sensing inhibitors (QSIs) are an attractive alternative to antibiotic growth promoters in farmed animal nutrition. The goal of the study was the diet supplementation of Arbor Acres chickens with quercetin (QC), vanillin (VN), and umbelliferon (UF), which are plant-derived QSIs preliminarily showing [...] Read more.
Quorum sensing inhibitors (QSIs) are an attractive alternative to antibiotic growth promoters in farmed animal nutrition. The goal of the study was the diet supplementation of Arbor Acres chickens with quercetin (QC), vanillin (VN), and umbelliferon (UF), which are plant-derived QSIs preliminarily showing cumulative bioactivity. Chick cecal microbiomes were analyzed by 16s rRNA sequencing, inflammation status was assessed by blood sample analyses, and zootechnical data were summarized in the European Production Efficiency Factor (EPEF). When compared to the basal diet control group, a significant increase in the Bacillota:Bacteroidota ratio in the cecal microbiome was found in all experimental subgroups, with the highest expression > 10 at VN + UV supplementation. Bacterial community structure in all experimental subgroups was enriched with Lactobacillaceae genera and also changed in the abundance of some clostridial genera. Indices of richness, alpha diversity, and evenness of the chick microbiomes tended to increase after dietary supplementation. The peripheral blood leukocyte content decreased by 27.9–45.1% in all experimental subgroups, likely due to inflammatory response reduction following beneficial changes in the cecal microbiome. The EPEF calculation showed increased values in VN, QC + UF, and, especially, VN + UF subgroups because of effective feed conversion, low mortality, and broiler weight daily gain. Full article
(This article belongs to the Special Issue Natural Compounds Targeting Quorum Sensing in Microorganisms)
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14 pages, 1604 KiB  
Article
Quorum Sensing in Halorubrum saccharovorum Facilitates Cross-Domain Signaling between Archaea and Bacteria
by Thomas P. Thompson, Alessandro Busetti and Brendan F. Gilmore
Microorganisms 2023, 11(5), 1271; https://doi.org/10.3390/microorganisms11051271 - 12 May 2023
Cited by 2 | Viewed by 2125
Abstract
Quorum Sensing (QS) is a well-studied intercellular communication mechanism in bacteria, regulating collective behaviors such as biofilm formation, virulence, and antibiotic resistance. However, cell–cell signaling in haloarchaea remains largely unexplored. The coexistence of bacteria and archaea in various environments, coupled with the known [...] Read more.
Quorum Sensing (QS) is a well-studied intercellular communication mechanism in bacteria, regulating collective behaviors such as biofilm formation, virulence, and antibiotic resistance. However, cell–cell signaling in haloarchaea remains largely unexplored. The coexistence of bacteria and archaea in various environments, coupled with the known cell–cell signaling mechanisms in both prokaryotic and eukaryotic microorganisms and the presence of cell–cell signaling mechanisms in both prokaryotic and eukaryotic microorganisms, suggests a possibility for haloarchaea to possess analogous cell–cell signaling or QS systems. Recently, N-acylhomoserine lactone (AHL)-like compounds were identified in haloarchaea; yet, their precise role—for example, persister cell formation—remains ambiguous. This study investigated the capacity of crude supernatant extract from the haloarchaeon Halorubrum saccharovorum CSM52 to stimulate bacterial AHL-dependent QS phenotypes using bioreporter strains. Our findings reveal that these crude extracts induced several AHL-dependent bioreporters and modulated pyocyanin and pyoverdine production in Pseudomonas aeruginosa. Importantly, our study suggests cross-domain communication between archaea and bacterial pathogens, providing evidence for archaea potentially influencing bacterial virulence. Using Thin Layer Chromatography overlay assays, lactonolysis, and colorimetric quantification, the bioactive compound was inferred to be a chemically modified AHL-like compound or a diketopiperazine-like molecule, potentially involved in biofilm formation in H. saccharovorum CSM52. This study offers new insights into putative QS mechanisms in haloarchaea and their potential role in interspecies communication and coordination, thereby enriching our understanding of microbial interactions in diverse environments. Full article
(This article belongs to the Special Issue Natural Compounds Targeting Quorum Sensing in Microorganisms)
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25 pages, 8405 KiB  
Article
Lactiplantibacillus plantarum-Derived Biosurfactant Attenuates Quorum Sensing-Mediated Virulence and Biofilm Formation in Pseudomonas aeruginosa and Chromobacterium violaceum
by Mitesh Patel, Arif Jamal Siddiqui, Syed Amir Ashraf, Malvi Surti, Amir Mahgoub Awadelkareem, Mejdi Snoussi, Walid Sabri Hamadou, Fevzi Bardakci, Arshad Jamal, Sadaf Jahan, Manojkumar Sachidanandan and Mohd Adnan
Microorganisms 2022, 10(5), 1026; https://doi.org/10.3390/microorganisms10051026 - 13 May 2022
Cited by 15 | Viewed by 3055
Abstract
Quorum sensing (QS) controls the expression of diverse biological traits in bacteria, including virulence factors. Any natural bioactive compound that disables the QS system is being considered as a potential strategy to prevent bacterial infection. Various biological activities of biosurfactants have been observed, [...] Read more.
Quorum sensing (QS) controls the expression of diverse biological traits in bacteria, including virulence factors. Any natural bioactive compound that disables the QS system is being considered as a potential strategy to prevent bacterial infection. Various biological activities of biosurfactants have been observed, including anti-QS effects. In the present study, we investigated the effectiveness of a biosurfactant derived from Lactiplantibacillus plantarum on QS-regulated virulence factors and biofilm formation in Pseudomonas aeruginosa and Chromobacterium violaceum. The structural analogues of the crude biosurfactant were identified using gas chromatography–mass spectrometry (GC–MS). Moreover, the inhibitory prospects of identified structural analogues were assessed with QS-associated CviR, LasA, and LasI ligands via in silico molecular docking analysis. An L. plantarum-derived biosurfactant showed a promising dose-dependent interference with the production of both violacein and acyl homoserine lactone (AHL) in C. violaceum. In P. aeruginosa, at a sub-MIC concentration (2.5 mg/mL), QS inhibitory activity was also demonstrated by reduction in pyocyanin (66.63%), total protease (60.95%), LasA (56.62%), and LasB elastase (51.33%) activity. The swarming motility and exopolysaccharide production were also significantly reduced in both C. violaceum (61.13%) and P. aeruginosa (53.11%). When compared with control, biofilm formation was also considerably reduced in C. violaceum (68.12%) and P. aeruginosa (59.80%). A GC–MS analysis confirmed that the crude biosurfactant derived from L. plantarum was a glycolipid type. Among all, n-hexadecanoic acid, oleic acid, and 1H-indene,1-hexadecyl-2,3-dihydro had a high affinity for CviR, LasI, and LasA, respectively. Thus, our findings suggest that the crude biosurfactant of L. plantarum can be used as a new anti-QS/antibiofilm agent against biofilm-associated pathogenesis, which warrants further investigation to uncover its therapeutic efficacy. Full article
(This article belongs to the Special Issue Natural Compounds Targeting Quorum Sensing in Microorganisms)
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23 pages, 4806 KiB  
Article
Characterization of Pseudomonas aeruginosa Quorum Sensing Inhibitors from the Endophyte Lasiodiplodia venezuelensis and Evaluation of Their Antivirulence Effects by Metabolomics
by Léonie Pellissier, Sara Leoni, Laurence Marcourt, Emerson Ferreira Queiroz, Nicole Lecoultre, Luis-Manuel Quiros-Guerrero, Morgane Barthélémy, Véronique Eparvier, Jérôme Chave, Didier Stien, Katia Gindro, Karl Perron and Jean-Luc Wolfender
Microorganisms 2021, 9(9), 1807; https://doi.org/10.3390/microorganisms9091807 - 25 Aug 2021
Cited by 4 | Viewed by 4521
Abstract
The opportunistic pathogen Pseudomonas aeruginosa is one of the “critical priority pathogens” due to its multidrug resistance to a wide range of antibiotics. Its ability to invade and damage host tissues is due to the use of quorum sensing (QS) to collectively produce [...] Read more.
The opportunistic pathogen Pseudomonas aeruginosa is one of the “critical priority pathogens” due to its multidrug resistance to a wide range of antibiotics. Its ability to invade and damage host tissues is due to the use of quorum sensing (QS) to collectively produce a plethora of virulence factors. Inhibition of QS is an attractive strategy for new antimicrobial agents because it disrupts the initial events of infection without killing the pathogen. Highly diverse microorganisms as endophytes represent an under-explored source of bioactive natural products, offering opportunities for the discovery of novel QS inhibitors (QSI). In the present work, the objective was to explore selective QSIs within a unique collection of fungal endophytes isolated from the tropical palm Astrocaryum sciophilum. The fungi were cultured, extracted, and screened for their antibacterial and specific anti-QS activities against P. aeruginosa. The endophytic strain Lasiodiplodia venezuelensis was prioritized for scaled-up fractionation for its selective activity, leading to the isolation of eight compounds in a single step. Among them, two pyran-derivatives were found to be responsible for the QSI activity, with an effect on some QS-regulated virulence factors. Additional non-targeted metabolomic studies on P. aeruginosa documented their effects on the production of various virulence-related metabolites. Full article
(This article belongs to the Special Issue Natural Compounds Targeting Quorum Sensing in Microorganisms)
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Review

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24 pages, 842 KiB  
Review
Quorum-Sensing Inhibition by Gram-Positive Bacteria
by Evgeniya V. Prazdnova, Andrey V. Gorovtsov, Nikita G. Vasilchenko, Maxim P. Kulikov, Varvara N. Statsenko, Anna A. Bogdanova, Alexandr G. Refeld, Yaroslav A. Brislavskiy, Vladimir A. Chistyakov and Michael L. Chikindas
Microorganisms 2022, 10(2), 350; https://doi.org/10.3390/microorganisms10020350 - 3 Feb 2022
Cited by 41 | Viewed by 7545
Abstract
The modern paradigm assumes that interspecies communication of microorganisms occurs through precise regulatory mechanisms. In particular, antagonism between bacteria or bacteria and fungi can be achieved by direct destruction of the targeted cells through the regulated production of antimicrobial metabolites or by controlling [...] Read more.
The modern paradigm assumes that interspecies communication of microorganisms occurs through precise regulatory mechanisms. In particular, antagonism between bacteria or bacteria and fungi can be achieved by direct destruction of the targeted cells through the regulated production of antimicrobial metabolites or by controlling their adaptive mechanisms, such as the formation of biofilms. The quorum-quenching phenomenon provides such a countermeasure strategy. This review discusses quorum-sensing suppression by Gram-positive microorganisms, the underlying mechanisms of this process, and its molecular intermediates. The main focus will be on Gram-positive bacteria that have practical applications, such as starter cultures for food fermentation, probiotics, and other microorganisms of biotechnological importance. The possible evolutionary role of quorum-quenching mechanisms during the development of interspecies interactions of bacteria is also considered. In addition, the review provides possible practical applications for these mechanisms, such as the control of pathogens, improving the efficiency of probiotics, and plant protection. Full article
(This article belongs to the Special Issue Natural Compounds Targeting Quorum Sensing in Microorganisms)
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