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Organic Synthesis of Nitrogen-Containing Molecules

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1766

Special Issue Editors


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Guest Editor
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA
Interests: synthetic methodologies; new chiral reagents; asymmetric synthesis and catalysis; new chirality and aggregational control of chirality
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Guest Editor
Department of Chemistry, Eastern Institute of Technology, Ningbo 315200, China
Interests: synthetic organic chemistry; asymmetric catalysis; biocatalysis and medicinal chemistry

Special Issue Information

Dear Colleagues,

Numerous drugs and biomaterials utilize nitrogen-containing structural units to impart specific biomedical functional properties. Examples include small amino compounds that can be cyclic or noncyclic, chiral or achiral, and either monomeric or oligomeric. Simultaneously, in the field of materials science, electrical and optical properties can also depend heavily on the availability of these nitrogen-containing compounds. Research into organic circularly polarized luminescent (CPL) materials has emerged as a particularly active and significant area of interest. The development of novel synthetic methodologies for these relevant compounds has been a focus within the organic chemistry community for many decades. As such, this Special Issue welcomes, but is not limited to, submissions from the following range of areas:

  • C(sp2)-H and C(sp2)-H functionalization with nitrogen-containing groups.
  • Asymmetric synthesis and catalysis approaches to amino products.
  • N-heterocycles inside and outside rings.
  • Noncyclic amino compounds, including α- and β-amino acid derivatives.
  • New protection and deprotection of known and new protection groups.
  • Solid-phase and solution-phase peptide synthesis.
  • New properties of known and new amino products.

Prof. Dr. Guigen Li
Prof. Dr. Guofu Zhong
Guest Editors

Manuscript Submission Information

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Keywords

  • asymmetric synthesis
  • N-heterocycles
  • noncyclic amino compound
  • amino compound
  • new synthetic methodologies

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Published Papers (2 papers)

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Research

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9 pages, 1629 KiB  
Communication
Visible-Light-Induced Singlet Oxygen-Promoted Arylation and Alkylation of Quinoxalin-2(1H)-ones and Quinolines
by Renjun Tan, Hequn Yang, Min Jiang and Peijun Song
Molecules 2024, 29(21), 5113; https://doi.org/10.3390/molecules29215113 - 29 Oct 2024
Viewed by 1138
Abstract
We report a green and efficient visible-light-driven method for the arylation and alkylation of quinoxalin-2(1H)-ones and quinolines. This catalyst-free process utilizes air as the oxidant, offering mild reaction conditions, environmental sustainability, and broad functional group compatibility. The approach enables the synthesis of aryl [...] Read more.
We report a green and efficient visible-light-driven method for the arylation and alkylation of quinoxalin-2(1H)-ones and quinolines. This catalyst-free process utilizes air as the oxidant, offering mild reaction conditions, environmental sustainability, and broad functional group compatibility. The approach enables the synthesis of aryl and alkyl derivatives of quinoxalin-2(1H)-ones and quinolines with high to excellent yields. Full article
(This article belongs to the Special Issue Organic Synthesis of Nitrogen-Containing Molecules)
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Review

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28 pages, 7433 KiB  
Review
N,N- and N,O-Bidentate-Chelation-Assisted Alkenyl C–H Functionalization
by Yawei Zhang, Chengxing Peng, Xiaoli Li, Xiuying Liu, Liyuan Ding, Guofu Zhong and Jian Zhang
Molecules 2025, 30(8), 1669; https://doi.org/10.3390/molecules30081669 - 8 Apr 2025
Viewed by 222
Abstract
Chelation-assisted olefinic C–H functionalization has been demonstrated to be a powerful method of constructing multi-substituted alkenes from simpler ones. This strategy produces complex alkenes in a regio- and stereoselective manner, followed by C–H endo- and exo-cyclometallation. Among the various directing groups developed, N,N- [...] Read more.
Chelation-assisted olefinic C–H functionalization has been demonstrated to be a powerful method of constructing multi-substituted alkenes from simpler ones. This strategy produces complex alkenes in a regio- and stereoselective manner, followed by C–H endo- and exo-cyclometallation. Among the various directing groups developed, N,N- and N,O-bidentate directing groups are the most widely used to selectively promote C–H functionalization due to their fine, tunable, and reversible coordination with the metal center. In this review, we discuss various N,N- and N,O-bidentate directing group-assisted olefinic C–H bond functionalization reactions, including alkenylation, alkylation, arylation, thiolation, silylation, halogenation, and cyclization. Full article
(This article belongs to the Special Issue Organic Synthesis of Nitrogen-Containing Molecules)
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