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Advances in Novel Pesticide Discovery, 2nd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Applied Chemistry".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 834

Special Issue Editors


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Guest Editor
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China
Interests: pesticide chemistry; medicinal chemistry; heterocycles synthesis

E-Mail Website
Guest Editor
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
Interests: bioactive molecules; synthetic strategies; structure-activity relationship
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pesticides are an essential tool for modern agriculture and the global food supply. On the basis of their target organisms, pesticides can be classified into insecticides, fungicides, herbicides, acaricides, nematicides, plant growth regulators (PGR), herbicide safeners, etc. Due to the negative impacts some synthetic pesticides have on human health and the environment, the development and application of safe and environmentally friendly pesticides is a major focus of researchers. For this purpose, synthetic pesticides with high activity rates and unique mechanisms of action should be discovered. In this process, the novel lead compounds should be isolated or synthesized, their structures should be elucidated, their biological activities should be screened, their mode of action should be studied, and their structure–activity relationship should be obtained. Natural products are an excellent alternative to synthetic pesticides, and the discovery of natural products as green pesticides is an attractive pursuit. The technological advancement of pesticide formulations (such as controlled release pesticides) is also gaining attention. In conclusion, this Special Issue will consider the most recent and significant developments in pesticide discovery, including new pesticide molecules, new modes of action, new methodologies or techniques, etc.

Prof. Dr. Hong Dai
Prof. Dr. Jian-Quan Weng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pesticide molecules
  • synthesis
  • biological activity
  • mode of action
  • isolation
  • application

Related Special Issue

Published Papers (1 paper)

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Research

16 pages, 4983 KiB  
Article
Antibacterial Activities and Underlying Mechanisms of the Compound SYAUP-491 against Xanthomonas oryzae pv. oryzae
by Lina Li, Yuxin Wang, He Liu, Wei Liu, Xinchen Zhang, Mengnan An, Miao Yu, Yuanhua Wu, Xinghai Li and Jianzhong Wang
Molecules 2024, 29(6), 1413; https://doi.org/10.3390/molecules29061413 - 21 Mar 2024
Viewed by 599
Abstract
SYAUP-491 is a novel alkyl sulfonamide. In this study, in vivo and in vitro tests were performed along with a proteomic analysis to determine the effects and underlying mechanisms of the antibacterial activity of SYAUP-491 against the causative agent of bacterial leaf blight [...] Read more.
SYAUP-491 is a novel alkyl sulfonamide. In this study, in vivo and in vitro tests were performed along with a proteomic analysis to determine the effects and underlying mechanisms of the antibacterial activity of SYAUP-491 against the causative agent of bacterial leaf blight in rice. The antibacterial test results suggested that SYAUP-491 exhibited significant activities against Xanthomonas oryzae pv. oryzae (Xoo) in vitro and in vivo. The minimal EC50 values reached 6.96 μg/mL and the curative activity reached 74.1%. Detailed studies demonstrated that SYAUP-491 altered membrane permeability and caused morphological changes. Based on proteomics results, SYAUP-491 might inhibit bacterial protein synthesis. SYAUP-491 may disrupt and alter cell membrane permeability and could further act on ribosomes in the bacterial body. Given the above results, SYAUP-491 could serve as a new lead compound in the research of antibacterial control of plant pathogenic bacterial disease. Full article
(This article belongs to the Special Issue Advances in Novel Pesticide Discovery, 2nd Edition)
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