DYRK Protein Kinases: Function and Inhibition

Dear Colleagues,

DYRKs (dual-specificity tyrosine-regulated kinases) are an evolutionarily conserved family of protein kinases. The substrate proteins phosphorylated by DYRKs are very diverse and are involved in the regulation of various intracellular events. DYRKs have attracted considerable attention as drug targets in several diseases. DYRK1A has been identified as a drug target in Alzheimer's disease and Down syndrome. In addition, other DYRK protein kinases are also attracting attention as drug targets in cancer and other diseases. This Special Issue reviews and reports on the involvement of DYRK family kinases in various diseases and the current status of the research on and development of inhibitors for disease treatment.

Prof. Dr. Isao Kii
Guest Editor

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