DYRK Protein Kinases: Function and Inhibition
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 38
Special Issue Editor
Interests: inhibitor
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Special Issue Information
Dear Colleagues,
DYRKs (dual-specificity tyrosine-regulated kinases) are an evolutionarily conserved family of protein kinases. The substrate proteins phosphorylated by DYRKs are very diverse and are involved in the regulation of various intracellular events. DYRKs have attracted considerable attention as drug targets in several diseases. DYRK1A has been identified as a drug target in Alzheimer's disease and Down syndrome. In addition, other DYRK protein kinases are also attracting attention as drug targets in cancer and other diseases. This Special Issue reviews and reports on the involvement of DYRK family kinases in various diseases and the current status of the research on and development of inhibitors for disease treatment.
Prof. Dr. Isao Kii
Guest Editor
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Keywords
- DYRK1A
- DYRK1B
- DYRK2
- DYRK3
- DYRK4
- Down syndrome
- metabolic syndrome
- cancer
- cilia
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