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Modern Trends in Fluorescent Probes

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 4448

Special Issue Editor


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Guest Editor
College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, China
Interests: nanoprobe; fluorescent probes; molecular spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue has been devised to broadly discuss the applications of fluorescent probes in the fields of chemistry, medicine, biology, pharmacology, and physiology. Fluorescent probes include light-emitting groups, linking groups, and recognition groups in structure. Recognition groups are usually used to identify small molecular substances; these small molecular substances, such as metal ions, enzymes, thiols, reactive oxygen and nitrogen species, H+, etc., play a crucial role in physiological processes, and their concentrations are often abnormal. This is closely related to diseases including stroke, osteoporosis, cardiovascular disease, Alzheimer's disease, myocardial infarction, and even tumors. Fluorescent probes have the advantages of simple operation, good selectivity, and high sensitivity and are the most commonly and widely used fluorescent analysis methods. So far, fluorescent probes have been widely used in the determination of small molecules, imaging of biological tissues, and disease diagnosis. Therefore, it is of great significance to collect organic small molecule fluorescent probes for detection, imaging, and their potential applications in the field of clinical diagnosis in this Special Issue.

Dr. Yonglei Chen
Guest Editor

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Keywords

  • One-photon fluorescent probes
  • Two-photon fluorescent probes
  • Multi-photon fluorescent probes
  • Upconverting fluorescent probes
  • AIE fluorescent probes

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Published Papers (2 papers)

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Research

13 pages, 2288 KiB  
Article
Smartphone-Based Dopamine Detection by Fluorescent Supramolecular Sensor
by Rossella Santonocito, Nunzio Tuccitto, Andrea Pappalardo and Giuseppe Trusso Sfrazzetto
Molecules 2022, 27(21), 7503; https://doi.org/10.3390/molecules27217503 - 3 Nov 2022
Cited by 15 | Viewed by 2455
Abstract
Supramolecular recognition of dopamine by two quinoxaline cavitands was studied in solution by fluorescence titrations, ESI-MS and ROESY measurements. In addition, the tetraquinoxaline cavitand was dropped onto a siloxane-based polymeric solid support, obtaining a sensor able to detect dopamine in a linear range [...] Read more.
Supramolecular recognition of dopamine by two quinoxaline cavitands was studied in solution by fluorescence titrations, ESI-MS and ROESY measurements. In addition, the tetraquinoxaline cavitand was dropped onto a siloxane-based polymeric solid support, obtaining a sensor able to detect dopamine in a linear range of concentrations 10 Mm–100 pM, with a detection limit of 1 pM, much lower than the normal concentration values in the common human fluids (plasma, urine and saliva), by using a simple smartphone as detector. This sensor shows also good selectivity for dopamine respect to the other common analytes contained in a saliva sample and can be reused after acid–base cycles, paving the way for the realization of real practical sensor for human dopamine detection. Full article
(This article belongs to the Special Issue Modern Trends in Fluorescent Probes)
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19 pages, 12464 KiB  
Article
Dual-State Emission of 2-(Butylamino)Cinchomeronic Dinitrile Derivatives
by Konstantin V. Lipin, Mikhail Yu. Ievlev, Anastasiya I. Ershova and Oleg V. Ershov
Molecules 2022, 27(21), 7144; https://doi.org/10.3390/molecules27217144 - 22 Oct 2022
Cited by 2 | Viewed by 1674
Abstract
New representatives of 2-(butylamino)cinchomeronic dinitrile derivatives were synthesized as promising fluorophores showing dual-state emission. To characterize the influence of the length (from methyl to butyl) and the structure (both linear and branched) of the alkyl substituent at the amino nitrogen atom, the spectral [...] Read more.
New representatives of 2-(butylamino)cinchomeronic dinitrile derivatives were synthesized as promising fluorophores showing dual-state emission. To characterize the influence of the length (from methyl to butyl) and the structure (both linear and branched) of the alkyl substituent at the amino nitrogen atom, the spectral fluorescence properties of all synthesized compounds were carefully studied both in solution and in solid state. The highest photoluminescence quantum yield values of 63% were noted for solutions of 2-(butylamino)-6-phenylpyridine-3,4-dicarbonitrile in DCM and 2-(butylamino)-5-methyl-6-phenylpyridine-3,4-dicarbonitrile in toluene. Full article
(This article belongs to the Special Issue Modern Trends in Fluorescent Probes)
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