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Recent Advances in Fluorescent Probes for the Detection of Biomolecules

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 1115

Special Issue Editor


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Guest Editor
Key Laboratory of Chemo/Biosensing and Detection, College of Chemical and Materials Engineering, Xuchang University, Xuchang 461000, China
Interests: fluorescent probe; small molecules; synthesis; fluorescence detection; bioimaging

Special Issue Information

Dear Colleagues,

Biological active species play a vital role in various physiological processes. It is significant to reveal the different functions of these important species, which have attracted extensive attention recently. Therefore, the detecting and imaging of these bioactive species have become an important research topic. Fluorescent probes and fluorescent imaging have been recognized as the most vigorous techniques to detect these reactive species due to their high sensitivity, selectivity and noninvasive visualization features. Thus, the development of novel fluorescent probes for detecting and imaging of biological active species in living system is urgently needed.

Prof. Dr. Zhihong Xu
Guest Editor

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Keywords

  • fluorescent probes
  • fluorescent sensors
  • biological active species
  • detecting
  • bioimaging

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Published Papers (1 paper)

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Research

13 pages, 2775 KiB  
Article
Comparison of Reactive Sites in 2(1H)-Quinolone Derivatives for the Detection of Biologically Important Sulfur Compounds
by Jolanta Kolińska, Aleksandra Grzelakowska, Marcin Szala and Radosław Podsiadły
Molecules 2023, 28(16), 5965; https://doi.org/10.3390/molecules28165965 - 9 Aug 2023
Viewed by 838
Abstract
Novel fluorescent probes based on 2(1H)-quinolone skeleton containing a malonate group (Q1Q3) were synthesized and proposed for biothiols detection. Their chemical reactivity toward thiols was compared to the reactivity of derivative having a dicyanovinyl group (Q4 [...] Read more.
Novel fluorescent probes based on 2(1H)-quinolone skeleton containing a malonate group (Q1Q3) were synthesized and proposed for biothiols detection. Their chemical reactivity toward thiols was compared to the reactivity of derivative having a dicyanovinyl group (Q4) as a reactive site. The detailed photophysical properties of these compounds were assessed through the determination of absorption and fluorescence spectra, fluorescence quantum yield, and fluorescence lifetime. In the presence of biothiols, an increase in the fluorescence intensity of compounds Q1Q3 and a hypsochromic shift in their emission bands were observed. In contrast, the compound with the dicyanovinyl group (Q4) in the presence of biothiols and cyanide ion showed the quenching of fluorescence, while a fluorescence “turn on” effect was observed toward reactive sulfur species. Full article
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