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New Trends in the Design of Metal Nanoparticles and Their Medical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 3827

Special Issue Editor

Dr. Jianbin Xu

E-Mail Website
Guest Editor
School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, China
Interests: biological materials; tissue engineering and regenerative medicine; stem cell therapy; nanomedicine

Special Issue Information

Dear Colleagues,

With the continuous development of nanotechnology, metal nanoparticles, with their excellent physical and chemical properties, have received more and more attention from researchers and have been widely used in biomedical and life sciences and other fields, such as the construction and application of metal nanomaterials in drug-delivery systems and the use of metal nanoparticles as optical probes in biological imaging. At present, the research of metal nanoparticles mainly focuses on metal nanostructures such as nanocages, gold nanospheres, nanoparticles and nanorods. Based on metal nanoclusters, such as gold nanoclusters, silver nanoclusters, platinum nanoclusters, copper nanoclusters and other metal nanoclusters. Metal–organic frameworks (MOFs) are based on the coordination chemical assembly of metal ions and organic ligands. Metal nanoparticles are widely used in drug delivery, biological imaging, biomarkers, biosensing, gene therapy and other aspects because of their molecular properties, functional diversity and adjustability of structure and composition.

Dr. Jianbin Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal nanoparticles
  • metal nanoclusters
  • metal–organic frameworks
  • nanomedicine

Published Papers (2 papers)

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Research

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16 pages, 4729 KiB  
Article
Biosynthesis and Characterization of Silver Nanoparticles Using Tribulus terrestris Seeds: Revealed Promising Antidiabetic Potentials
by Abdur Rahman, Gauhar Rehman, Nasrullah Shah, Muhammad Hamayun, Sajid Ali, Abid Ali, Said karim Shah, Waliullah Khan, Muhammad Ishaq Ali Shah and Abdulwahed Fahad Alrefaei
Molecules 2023, 28(10), 4203; https://doi.org/10.3390/molecules28104203 - 20 May 2023
Cited by 5 | Viewed by 2162
Abstract
Green synthesis is the most effective and environmentally friendly way to produce nanoparticles. The present research aimed at the biosynthesizing of silver nanoparticles (AgNPs) using Tribulus terrestris seed extract as the reducing and stabilizing agent and investigating their anti-diabetic properties. Fourier transformation infrared [...] Read more.
Green synthesis is the most effective and environmentally friendly way to produce nanoparticles. The present research aimed at the biosynthesizing of silver nanoparticles (AgNPs) using Tribulus terrestris seed extract as the reducing and stabilizing agent and investigating their anti-diabetic properties. Fourier transformation infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and UV-Vis spectroscopy were used to analyze the synthesized silver nanoparticles from Tribulus terrestris (TT-AgNPs). The spectroscopic characterization revealed a surface Plasmon resonance band at 380 nm, which verified the development of TT-AgNPs. The transmittance peaks were observed at 596, 1450, 1631, 2856, 2921, and 3422 cm−1 through the FTIR spectrophotometer. The XRD spectrum showed four distinct diffraction peaks in the 2θ range at 20° to 60°. Intense peaks were at 26.32°, 30.70°, 44.70°, 56.07°, 53.75°, 66.28°, and 75.32°. The SEM analysis revealed that the prepared TT-AgNPs were clustered loosely with a smooth and spherical structure and were of relatively uniform size. The in vitro antidiabetic potential of TT-AgNPs was assessed by using glucose yeast uptake, glucose adsorption, and alpha-amylase assays. TT-AgNPs showed the highest activity (78.45 ± 0.84%) of glucose uptake by yeast at 80 µg/mL. In the glucose adsorption assay, the highest activity of TT-AgNPs was 10.40 ± 0.52% at 30 mM, while in the alpha-amylase assay, TT-AgNPs exhibited the maximum activity of 75.68 ± 0.11% at 100 µg/mL. The results indicate a substantial anti-diabetic effect of the TT-AgNPs. Furthermore, the in vivo antidiabetic study was performed on TT-AgNPs in streptozotocin-induced diabetic mice. After receiving TT-AgNPs treatment for 30 days, the mice were sacrificed for biochemical and histological analyses of pancreatic and liver samples, which demonstrated a good improvement when compared to the control group. Mice treated with TT-AgNPs showed a significant drop in blood sugar levels, showing that the biosynthesized TT-AgNPs have effective anti-diabetic properties. Full article
(This article belongs to the Special Issue New Trends in the Design of Metal Nanoparticles and Their Medical Applications)
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Review

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19 pages, 2631 KiB  
Review
Application of Metal-Based Nanomaterials in In Vitro Diagnosis of Tumor Markers: Summary and Prospect
by Xiaobo Yang, Shaodian Zhang and Nong Lin
Molecules 2023, 28(11), 4370; https://doi.org/10.3390/molecules28114370 - 26 May 2023
Cited by 1 | Viewed by 1211
Abstract
Cancer, which presents with high incidence and mortality rates, has become a significant health threat worldwide. However, there is currently no effective solution for rapid screening and high-quality treatment of early-stage cancer patients. Metal-based nanoparticles (MNPs), as a new type of compound with [...] Read more.
Cancer, which presents with high incidence and mortality rates, has become a significant health threat worldwide. However, there is currently no effective solution for rapid screening and high-quality treatment of early-stage cancer patients. Metal-based nanoparticles (MNPs), as a new type of compound with stable properties, convenient synthesis, high efficiency, and few adverse reactions, have become highly competitive tools for early cancer diagnosis. Nevertheless, challenges such as the difference between the microenvironment of detected markers and the real-life body fluids remain in achieving widespread clinical application of MNPs. This review provides a comprehensive review of the research progress made in the field of in vitro cancer diagnosis using metal-based nanoparticles. By delving into the characteristics and advantages of these materials, this paper aims to inspire and guide researchers towards fully exploiting the potential of metal-based nanoparticles in the early diagnosis and treatment of cancer. Full article
(This article belongs to the Special Issue New Trends in the Design of Metal Nanoparticles and Their Medical Applications)
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