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Exploration of Natural Compounds: Pharmaceutical, Phytochemical and Biological Analyses—2nd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 2026

Special Issue Editor


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Guest Editor
Department of Chemistry, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil
Interests: natural products; natural-product-based hybrids; herbal formulations; biotransformation biological properties
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chemical substances from nature represent a great source of biologically valuable molecules, and they are attracting increasing attention, especially with the incidence of new diseases. They also play an impactful role in drug discovery by unveiling new molecular skeletons and by inspiring the preparation of semisynthetic and hybrid prototypes. This Special Issue within the Natural Products Chemistry Section of Molecules aims to present recent and high-quality findings in the area of natural products. Original papers related to new compounds from plant species, mushrooms, macro-fungi, alga, food, microbial fermentation, microbial and enzymatic biotransformation and animals with significant biological potential are welcome. This Special Issue also considers results dealing with new pharmacological potential with the mechanisms of action of known natural substances, as well as those addressing the rational design and preparation of semisynthetic derivatives and the synthesis of natural-product-based hybrids with promising therapeutic potential. We would also like to receive results on dereplication studies and the quantification of main components (LCMS data, LCMS- and NMR-based metabolomic data) in new herbal formulations with a particular therapeutic application (antimicrobial, anticancer, anti-inflammatory, enzymatic effects, antihyperglycemic, antiprotozoal, etc.) as well as critical reviews on recent advances and attractive topics in natural products chemistry (new purification techniques, therapeutic potential, fermentation methods, etc.).

Prof. Dr. Louis Pergaud Sandjo
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • structure elucidation
  • natural-product-based hybrids
  • herbal formulations
  • biotransformation
  • biological properties

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Published Papers (1 paper)

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Research

26 pages, 2373 KiB  
Article
From Stem to Spectrum: Phytochemical Characterization of Five Equisetum Species and Evaluation of Their Antioxidant Potential
by Khadijeh Nosrati Gazafroudi, Lilo K. Mailänder, Rolf Daniels, Dietmar R. Kammerer and Florian C. Stintzing
Molecules 2024, 29(12), 2821; https://doi.org/10.3390/molecules29122821 - 13 Jun 2024
Viewed by 1812
Abstract
The Equisetaceae family, commonly known as horsetails, has been of scientific interest for decades due to its status as one of the most ancient extant vascular plant families. Notably, the corresponding species have found their place in traditional medicine, offering a wide array [...] Read more.
The Equisetaceae family, commonly known as horsetails, has been of scientific interest for decades due to its status as one of the most ancient extant vascular plant families. Notably, the corresponding species have found their place in traditional medicine, offering a wide array of applications. This study presents a comprehensive phytochemical analysis of polar secondary metabolites within the sterile stems of five distinct Equisetum species using HPLC–DAD-ESI-MSn. For this purpose, fresh plant material was extracted with acetone/water, and the resulting crude extracts were fractionated using dichloromethane, ethyl acetate, and n-butanol, respectively. The results reveal a complex array of compounds, including hydroxycinnamic acids, hydroxybenzoic acids, flavonoids, and other phenolic compounds. In addition, total phenolic contents (Folin–Ciocalteu assay) and antioxidant activities (DPPH assay) of the plant extracts were evaluated using spectrophotometric methods. The present comparative analysis across the five species highlights both shared and species-specific metabolites, providing valuable insights into their chemical diversity and potential pharmacological properties. Full article
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