molecules-logo

Journal Browser

Journal Browser

Alkaloids in Medicinal Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 1440

Special Issue Editor


E-Mail Website
Guest Editor
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
Interests: chemical biology of natural products; bioactive small molecules; natural products chemistry

Special Issue Information

Dear Colleagues,

Alkaloids are a class of natural products widely distributed in nature which bear diverse structures and biological functions. They are one of the most important sources of new drugs. Alkaloid chemistry is an important research direction in the field of natural products and medicinal chemistry. The main aim of this Special Issue on “Alkaloids in Medicinal Chemistry” is to collect contributions, both in the form of original research and review articles, to cover studies concerning the identification of alkaloids and synthetic bioactive derivatives with relevant biological activities.

Dr. Duozhi Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • alkaloids
  • biological activity
  • structural modification
  • target protein
  • modes of action

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

7 pages, 714 KiB  
Article
Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats
by Noemi Oliveira Monteiro, Theresa de Moura Monteiro, Thalya Soares R. Nogueira, Jacqueline Rodrigues Cesar, Lara Pessanha S. Nascimento, Karoline Azerêdo Campelo, Graziela Rangel Silveira, Fernanda Antunes, Daniela Barros de Oliveira, Almir Ribeiro de Carvalho Junior, Raimundo Braz-Filho and Ivo José Curcino Vieira
Molecules 2022, 27(20), 6895; https://doi.org/10.3390/molecules27206895 - 14 Oct 2022
Cited by 2 | Viewed by 1131
Abstract
The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum. Its structure was elucidated by the spectral data of 1H and 13C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS). The antihypertensive activity was investigated by intravenous infusion in [...] Read more.
The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum. Its structure was elucidated by the spectral data of 1H and 13C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS). The antihypertensive activity was investigated by intravenous infusion in Wistar rats. This alkaloid significantly reduced (p < 0.05) the systolic, median, and diastolic blood pressures of rodents, without causing motor incoordination and imbalance in the rotarod test. The results indicate that the alkaloid Aspidocarpine exerts its antihypertensive activity without causing sedation or the impairment of motor functions. Full article
(This article belongs to the Special Issue Alkaloids in Medicinal Chemistry)
Show Figures

Figure 1

Back to TopTop