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Anti-Inflammatory Drug as a Treatment for Psychiatric Disorders

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 1882

Special Issue Editor


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Guest Editor
Department of Nursing, School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
Interests: anti-inflammatory drugs; cytokines; glia cells; neuro-inflammation; pharmacology; prostaglandins; psychopharmacology; psychiatric disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, data have accumulated suggesting that inflammation may contribute to the pathophysiology of psychiatric disorders such as depression, bipolar disorder, and schizophrenia. Supporting findings include the following: (i) patients with psychiatric disorders were found to have increased levels of pro-inflammatory mediators in the plasma and in postmortem brain samples; (ii) psychotropic medications exhibited potent anti-inflammatory effects both in animal and human studies; and (iii) classic anti-inflammatory drugs such as corticosteroids and nonsteroidal anti-inflammatory drugs exerted beneficial effects in patients with psychiatric disorders.

This Special Issue will address the role of anti-inflammatory and anti-infectious drugs as a treatment for psychiatric disorders; original articles and review papers that address this topic are welcomed.

Dr. Abed N. Azab
Guest Editor

Manuscript Submission Information

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Keywords

  • anti-inflammatory drugs
  • bipolar affective disorder
  • corticosteroids
  • COX inhibitors
  • C-reactive protein
  • cytokines
  • depression
  • efficacy
  • minocycline
  • immune disturbances
  • inflammation
  • mood disorders
  • prostaglandins
  • psychiatric illnesses
  • schizophrenia
  • side effects

Published Papers (1 paper)

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Research

13 pages, 2564 KiB  
Article
Adenosine A2A Receptor Antagonist Improves Cognitive Impairment by Inhibiting Neuroinflammation and Excitatory Neurotoxicity in Chronic Periodontitis Mice
by Wendan He, Xianlong Xie, Chenxi Li, Huang Ding and Jishi Ye
Molecules 2022, 27(19), 6267; https://doi.org/10.3390/molecules27196267 - 23 Sep 2022
Cited by 2 | Viewed by 1594
Abstract
The adenosine A2A receptor antagonist SCH58261 has been reported to have anti-inflammatory effects. However, its role in chronic periodontitis (CP)-induced cognitive impairment, which is associated with Porphyromonas gingivalis lipopolysaccharide (P. gingivalis LPS), remains unclear. This study investigated the role of SCH58261 [...] Read more.
The adenosine A2A receptor antagonist SCH58261 has been reported to have anti-inflammatory effects. However, its role in chronic periodontitis (CP)-induced cognitive impairment, which is associated with Porphyromonas gingivalis lipopolysaccharide (P. gingivalis LPS), remains unclear. This study investigated the role of SCH58261 in mice with CP-induced cognitive impairment. C57BL/6J mice were used to develop CP model by injecting 0.5 mg/kg P. gingivalis LPS into the palatal gingival sulcus of maxillary first molars twice a week for four weeks. The mice were divided into control, P. gingivalis LPS (P-LPS), P-LPS + SCH58261, and SCH58261 groups. The passive avoidance test (PAT) and Morris water maze (MWM) were used to assess cognition in mice. Furthermore, CD73/adenosine, neuroinflammation, glutamate transporters, and glutamate were assessed. Compared with the P-LPS group, 0.1 and 0.5 mg/kg SCH58261 increased latency and decreased error times in PAT, but increased platform crossing number in MWM. SCH58261 inhibited microglial activation, and decreased pro-inflammatory cytokines and glutamate levels, but increased GLT-1 and PSD95 expression in the hippocampus. This was the first report of SCH58261 treatment for CP-induced cognitive impairment, which may be related to its anti-inflammatory activities and anti-glutamate excitatory neurotoxicity. This suggests that SCH58261 can be used as a novel agent to treat cognitive impairment. Full article
(This article belongs to the Special Issue Anti-Inflammatory Drug as a Treatment for Psychiatric Disorders)
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