Novel Anticancer Therapies Targeting Stem Cells
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (24 August 2023) | Viewed by 435
Special Issue Editor
Interests: cancer therapy; medicinal plant; chemotherapy; chemoprevention
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The therapeutic effectiveness of conventional anticancer modalities has been limited by undesirable side effects, resistance to treatment, and cancer recurrence. These therapeutic strategies eliminate the highly proliferative cells forming the tumor bulk but fail to eradicate the sub-population of self-renewing cancer stem cells (CSCs). The CSCs that escape treatment can develop resistance and give rise to diverse tumor populations, resulting in cancer recurrence. Over the past decade, there has been growing interest in developing therapeutic approaches to eliminate these CSCs. Great efforts have been made to identify naturally derived or synthetic therapeutic agents that can target specific signaling pathways or cell surface biomarkers of CSCs in addition to delivering non-coding RNA to restore target gene expression. In recent years, combination cancer therapy has attracted considerable attention given its potential to simultaneously modulate multiple targets to intensify the therapeutic outcome against CSCs.
This Special Issue focuses on new trends in the development of therapeutic strategies to target CSCs. You are invited to submit original research articles and reviews relevant to this topic.
Prof. Dr. Hala Gali-Muhtasib
Guest Editor
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Keywords
- cancer stem cells
- chemoresistance
- gene therapy
- targeted therapy
- combination therapy
- natural products
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