Molecules, Volume 29, Issue 24

Resveratrol and its glucoside, piceid, are the primary stilbenes present in wine. These compounds are well known for their pharmaceutical properties. However, these compounds can undergo chemical transformations in wines, such as polymerization in th...

Viruses, known for causing widespread biological harm and even extinction, pose significant challenges to public health. Virus detection is crucial for accurate disease diagnosis and preventing the spread of infections. Recently, the outstanding anal...

In this study, a sustainable cellulose-based flame-retardant additive was developed, characterized, and incorporated into polypropylene (PP). Microcrystalline cellulose (Cel) was chemically modified with P₂O₅ using the solvent-free ball-milling mecha...

In this study, we explore the interactions between melittin, a cationic antimicrobial peptide, and model lipid membranes composed of the negatively charged phospholipids 1,2-dimyristoyl-sn-glycero-3-phosphoglycerol (DMPG) and 1,2-dimyristoyl-sn-glyce...

As a key means to solve energy and environmental problems, photocatalytic technology has made remarkable progress in recent years. Organic semiconductor materials offer structural diversity and tunable energy levels and thus attracted great attention...

Prostate cancer ranks as the fourth most common cancer among men, with approximately 1.47 million new cases reported annually. The emergence of prostate-specific membrane antigen (PSMA) as a critical biomarker has revolutionized the diagnosis and tre...

Cone snails of the genus Conus have evolved to produce structurally distinct and functionally diverse venom peptides for defensive and predatory purposes. This nature-devised delicacy enlightened drug discovery and for decades, the bioactive cone sna...

Pyrolysis is recognized as a promising technology for waste plastics management. Although there have been many studies on pyrolysis of waste plastics, there is still a lack of in-depth research on the mechanism of synergistic effect between mixed pla...

Apremilast (APR) is an anti-inflammatory drug commonly used in the treatment of psoriasis. In efforts to enhance its solubility, several cocrystals with similar structural features have been developed. This study investigates the cocrystallization of...

In this paper, the enhancement of thermochemical energy storage by alkali metal chloride salts-doped Ca-based sorbents is revealed by experiments and DFT calculations. The results indicate that NaCl and KCl doping increases the reaction rate and cycl...

In the era of artificial intelligence and Internet of Things, data storage has an important impact on the future development direction of data analysis. Resistive random-access memory (RRAM) devices are the research hotspot in the era of artificial i...

In the analytical quality by design (AQbD) framework, the design of experiments (DOE) plays a very important role, as it provides information about how experimental input variables influence critical method attributes. Based on the information obtain...

As a small-molecule gelator used as a stabilizer in gel emulsions, it has numerous advantages, such as low dosage, independence from phase ratios, and ease of control. In this study, a cholesterol derivative (CSA) was designed and synthesized to be u...

Bacterial contamination is a major public health concern on a global scale. Treatment resistance in bacterial infections is becoming a significant problem that requires solutions. We were interested in obtaining new polymeric functionalized compounds...

The most commonly used methods to chemically assess grape and wine quality with high sensitivity and selectivity require lengthy analysis time and can be resource intensive. Here, we developed a rapid and non-destructive method that would help in gra...

In this study, comparative analysis of calculated and experimental ¹³C NMR shifts for a wide range of model platinum complexes showed that, on the whole, the theory reproduces the experimental data well. The chemical shifts of carbon atoms directly b...

Epichlorohydrin is used as an intermediate for the synthesis of polymers and, more particularly, epoxy adhesives. The traditional process involves the cleavage of the carbon-chlorine bond in an alkaline solution. Here, we investigate the breakage of...

Meriolins (3-(pyrimidin-4-yl)-7-azaindoles) are synthetic hybrids of the naturally occurring alkaloids variolin and meridianin and display a strong cytotoxic potential. We have recently shown that the novel derivative meriolin 16 is highly cytot...

Mild hypophosphatasia (HPP) can be difficult to distinguish from other bone disorders in the absence of typical symptoms such as the premature loss of primary teeth. Therefore, this study aimed to analyze the crystallinity of hydroxyapatite (HAp) and...

The 2-(4-hydroxyphenoxy)benzamide scaffold is frequently found in a variety of bioactive compounds, displaying a broad spectrum of properties, such as antibacterial and antitumor effects. In this study, we developed a new method for synthesizing 2-(4...

Benzylic C–H oxidation to form carbonyl compounds, such as ketones, is a fundamental transformation in organic synthesis as it allows for the preparation of versatile intermediates. In this review, we highlight the synthesis of aromatic ketones...

It is necessary to overcome the relatively low conductivity of ionic liquids (ILs) caused by steric hindrance effects to improve their ability to passivate defects and inhibit ion migration to boost the photovoltaic performance of perovskite solar ce...

The rising prevalence of neurodegenerative disorders underscores the urgent need for effective interventions to prevent neuronal cell death. This study evaluates the neuroprotective potential of phytosome-encapsulated 6-gingerol- and 6-shogaol-enrich...

Glioblastoma (GBM) is the most common and aggressive form of brain cancer in adults, characterized by extensive growth, a high recurrence rate, and resistance to treatment. Growing research interest is focusing on the biological roles of natural comp...

Azurite, a natural mineral pigment consisting of basic copper carbonate (2CuCO₃·Cu(OH)₂), is one of the Middle Ages’ most common blue pigments. Why paintings originally coated with azurite appear blackened today remains debated. Using a...

In cases in which a rapid metabolism is the cause of an unfavorable pharmacokinetic profile, it is important to determine the Sites of Metabolism (SoMs) of a molecule to introduce the necessary modifications to improve the stability of the compound....

Phosphorescent sensors are essential for rapid visual sensing of volatile acids, due to their profound impact on ecosystems and human health. However, solid phosphorescent materials for acid-base stimulus response are still rare, and it is important...

Breast cancer remains one of the most prevalent and lethal malignancies in women, particularly the estrogen receptor-positive (ER+) subtype, which accounts for approximately 70% of cases. Traditional endocrine therapies, including aromatase inhibitor...

A new process route suitable for the industrial production of BAY2433334 has been developed in this paper, which avoids the patent limitations of the originator company of BAY2433334 to the preparation of BAY2433334. BAY2433334 is obtained from (2R)-...

The development of fluorescence-based methods for bioassays and medical diagnostics requires the design and synthesis of specific markers to target biological microobjects. However, biomolecular recognition in real cellular systems is not always as s...

In this work, α-tocopherol and trolox were studied as compounds that have high biological activity. α-Tocopherol is considered a food additive because the refining process of vegetable oils causes the depletion of this vitamin, and thus,...

Compounds containing the 1,2,4-triazole moiety in their structure exhibit broad biological activities. Many of these compounds demonstrate anti-inflammatory activity in vitro through various mechanisms, such as inhibiting COX-1/COX-2 and LOX, modulat...

Studies on radiosensitization of biological damage by O₂ began about a century ago and it remains one of the most significant subjects in radiobiology. It has been related to increased production of oxygen radicals and other reactive metabolites, but...

Thyme essential oils (EOs) have antioxidant, antiviral, antifungal, antibacterial, anti-inflammatory, and immunological properties and are used in medicine, food, feed additives, and cosmetics. Here, we made use of a multidimensional analytical metho...

Photo-thermo-electric conversion devices represent a promising technology for converting solar energy into electrical energy. Photothermal materials, as a critical component, play a significant role in efficient conversion from solar energy into ther...

It is well stablished that docosahexaenoic (DHA) and arachidonic (ARA) acids fulfill relevant biological activities, especially in newborns. However, oils containing these fatty acids are not always optimally digestible. To address this, various form...

Insectary plants, such as sweet alyssum, coriander, and white mustard, are well known for their traits that attract beneficial insects, allowing them to protect crops from pests. The aim of the study was to analyze the compounds that are important in...

This study explores the formation of functionalized carbon surfaces through shock compression of graphite in the presence of water, modeled using molecular dynamics and the ReaxFF reactive force field. The shock compression method produces activated...

In this study, the results of a comprehensive assessment of the variability in the occurrence of ten perfluorinated compounds (PFAS) in fish tissues originating from 2014 to 2019 from six fisheries in the Baltic Sea are presented. A total of 360 fish...

This study aimed to investigate the properties of tin(II) oxide (SnO) as an unconventional cross-linking agent for chloroprene (CR) and styrene–butadiene (SBR) rubbers compositions. The use of tin(II) oxide results from the need to reduce the u...

High consumption of ultra-processed foods, rich in sugar and unhealthy fats, has been linked to the onset of numerous chronic diseases. Consequently, there has been a growing shift towards a fiber-rich diet, abundant in fruits, vegetables, seeds, and...

High-Performance Thin Layer Chromatography (HPTLC) is widely utilized in natural products research due to its simplicity, low cost, and short total analysis time, including data treatment. While bioautography can be used for rapid detection of bioact...

As a sustainable alternative technology to the cost- and energy-intensive Haber–Bosch method, electrochemical nitrogen (N₂) reduction offers direct conversion of N₂ to NH₃ under ambient conditions. Direct use of noble metals or non-noble metals...

The recently developed phenoplast-related polymer, poly(benzofuran-co-arylacetic acid), presents a versatile molecular structure containing lactone and carboxylic acid functionalities that offer significant flexibility in creating cured materials wit...

This study aimed to investigate the effect of aminating waste newsprint paper with different aminating agents (ammonia/ammonia water, ethylenediamine, and diethylenetriamine) for the sorption efficiency of Reactive Black 5 (RB5) and Reactive Yellow 8...

Prostate cancer remains a significant global health concern, prompting ongoing exploration of novel therapeutic agents. Licochalcone A, a natural product in the chalcone family isolated from licorice root, is characterized by its enone structure and...

With the increasing societal demand for sustainable and renewable energy, supercapacitors have become research hotspots. Transition metal oxides, due to their high capacitance and abundant resources, are the preferred electrode materials. However, th...

The 4-aminoquinazoline scaffold is a privileged structure in medicinal chemistry. Regioselective nucleophilic aromatic substitution (S_NAr) for replacing the chlorine atom at the 4-position of 2,4-dichloroquinazoline precursors is well documented in t...

The textural properties of synthetic and natural clays in the sodium form and exchanged with tetramethylammonium cations (TMA⁺) were characterized using N₂ and Ar physisorption isotherms at cryogenic temperatures. Specific surface areas and micro/mes...

Background: Cardiovascular diseases constitute one of the leading causes of morbidity and mortality worldwide. Herbal medicines represent viable alternatives to the synthetic drugs currently employed in the control of hypertension. This study aimed t...