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Bioactive Compounds in Food Chemistry and/or Drug Discovery
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Bioactive Compounds in Food Chemistry and/or Drug Discovery

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Food Chemistry".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 3894

Special Issue Editors

Prof. Dr. Ahmed H. El-Ghorab

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Guest Editor
Department of Chemistry, College of Science, Jouf UniversityJouf University, Sakakah, Saudi Arabia
Interests: food chemistry; flavor; bioactive compounds
Dr. Mohamed A. Abdelgawad

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Guest Editor
Department of Pharmaceutical Chemistry, College of Pharmacy, Sakakah, Saudi Arabia
Interests: drug design; drug discovery
Dr. Mohamed Sadek Abdel-Bakky

E-Mail Website
Guest Editor
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
Interests: coagulation system; retinoid receptor idiosyncrasy
Prof. Dr. Osama M. Ahmed

E-Mail Website
Guest Editor
Molecular Physiology Division, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt
Interests: cancer; diabetes; obesity

Special Issue Information

Dear Colleagues,

Bioactive compounds in food chemistry, such as antioxidants, flavor and aroma enhancers, phenolic compounds, and additives and natural products containing polyphenols, are of great importance in various foods, especially to the human diet, mainly due to their ability to prevent many chronic diseases. Additionally, many compounds that have a high biological activity have been discovered in different foods, for example, different types of grains, nuts, fruits, and some drinks such as coffee, tea, etc. There are also some natural products that are added to food such as spices, herbs, etc. It has been found that there is a lot of scientific research and reference research that has dealt with the analysis and investigation of compounds that have high biological activity in food products in the scientific literature.

Secondary metabolites play a vital role in drug discovery and are considered to be the cornerstone for the application of folk medicines.

Secondary metabolites represent a new scaffold for the innovation of new drugs, which opens the way for the identification of new compounds with vital pharmacological action.

The scope of this Special Issue is to attract all scientific research and original reference research that focuses on biologically active compounds that are added to foods to maximize their use in different human or animal diets.

Additionally, there is also a focus on the uses and applications of secondary metabolites in the discovery of new drugs.

Reference papers may provide insight into selected bioactive compounds in food chemistry and may provide original scientific papers on the extraction, discovery, isolation, and study of properties of these new bioactive compounds in food. However, we welcome any other additions or suggestions from potential researchers.

Prof. Dr. Ahmed H. El-Ghorab
Dr. Mohamed A. Abdelgawad
Dr. Mohamed Sadek Abdel-Bakky
Prof. Dr. Osama M. Ahmed
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food chemistry
  • natural products
  • bioactive components

Published Papers (2 papers)

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Research

14 pages, 3266 KiB  
Article
Managing Encapsulated Oil Extract of Date Seed Waste for High Hydroxyl Radical Scavenging Assayed via Hybrid Photo-Mediated/Spectrofluorimetric Probing
by Amr A. Essawy, Khaled F. El-Massry, Ibrahim Hotan Alsohaimi and A. El-Ghorab
Molecules 2023, 28(13), 5160; https://doi.org/10.3390/molecules28135160 - 1 Jul 2023
Cited by 1 | Viewed by 1025
Abstract
This work addresses two research topics: the first concerns the specific/sensitive trapping of hydroxyl radicals (•OH), and the second concerns the efficacy of encapsulating natural antioxidants, potentially lengthening their preservation activity. For context, nano-titania was solar-irradiated to produce •OH, which [...] Read more.
This work addresses two research topics: the first concerns the specific/sensitive trapping of hydroxyl radicals (•OH), and the second concerns the efficacy of encapsulating natural antioxidants, potentially lengthening their preservation activity. For context, nano-titania was solar-irradiated to produce •OH, which was spectrofluorimetrically assessed, based on the selective aromatic hydroxylation of the non-fluorescent sodium terephthalate to 2-hydroxyterephthalate fluorophore. Fluorescence intensity is proportional to generated •OH. Thus, a simple/rapid indirect method was utilized to assess •OH precisely. Accordingly, novel photoluminescent system is outlined in order to assess the scavenging potentiality of •OH in date seed oil (DSO) in both its pure and encapsulated formulations (ECP–DSO), i.e., when fresh and 5 months after extraction and encapsulation, respectively. With the addition of 80 μg/mL DSO or ECP–DSO, the efficacy of •OH scavenging amounted to 25.12 and 63.39%, which increased to 68.65 and 92.72% when 200 μg/mL DSO or ECP–DSO, respectively, was added. Moreover, the IC50 of DSO and ECP–DSO is 136.6 and 62.1 µg/mL, respectively. Furthermore, DSO and ECP–DSO decreased the kinetics for producing •OH by ≈20 and 40%, respectively, relative to •OH generated in the absence of antioxidant. This demonstrates the benefits of encapsulation on the preservation activity of natural antioxidants, even after five months after extraction, in terms of its interesting activity when compared to synthetic antioxidants. The developed fluorimetric •OH probing upgrades antioxidant medicines, thus paving the way for theoretical/practical insights on mechanistic hydroxyl radical-damaging biology. Full article
(This article belongs to the Special Issue Bioactive Compounds in Food Chemistry and/or Drug Discovery)
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11 pages, 4694 KiB  
Article
Attenuation of Skeletal Muscle Atrophy Induced by Dexamethasone in Rats by Teaghrelin Supplementation
by Cian-Fen Jhuo, Sheng-Kuo Hsieh, Wen-Ying Chen and Jason T. C. Tzen
Molecules 2023, 28(2), 688; https://doi.org/10.3390/molecules28020688 - 10 Jan 2023
Cited by 5 | Viewed by 2556
Abstract
Muscle atrophy caused by an imbalance between the synthesis and the degradation of proteins is a syndrome commonly found in the elders. Teaghrelin, a natural compound from oolong tea, has been shown to promote cell differentiation and to inhibit dexamethasone-induced muscle atrophy in [...] Read more.
Muscle atrophy caused by an imbalance between the synthesis and the degradation of proteins is a syndrome commonly found in the elders. Teaghrelin, a natural compound from oolong tea, has been shown to promote cell differentiation and to inhibit dexamethasone-induced muscle atrophy in C2C12 cells. In this study, the therapeutic effects of teaghrelin on muscle atrophy were evaluated in Sprague Dawley rats treated with dexamethasone. The masses of the soleus, gastrocnemius and extensor digitorum longus muscles were reduced in dexamethasone-treated rats, and the reduction of these muscle masses was significantly attenuated when the rats were supplemented with teaghrelin. Accordingly, the level of serum creatine kinase, a marker enzyme of muscle proteolysis, was elevated in dexamethasone-treated rats, and the elevation was substantially reduced by teaghrelin supplementation. A decrease in Akt phosphorylation causing the activation of the ubiquitin–proteasome system and autophagy for protein degradation was detected in the gastrocnemius muscles of the dexamethasone-treated rats, and this signaling pathway for protein degradation was significantly inhibited by teaghrelin supplementation. Protein synthesis via the mTOR/p70S6K pathway was slowed down in the gastrocnemius muscles of the dexamethasone-treated rats and was significantly rescued after teaghrelin supplementation. Teaghrelin seemed to prevent muscle atrophy by reducing protein degradation and enhancing protein synthesis via Akt phosphorylation. Full article
(This article belongs to the Special Issue Bioactive Compounds in Food Chemistry and/or Drug Discovery)
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